Fatiha Nassir, PhD
Assistant Research Professor
Clinical and Research Interests
- Hepatic and intestinal lipid metabolism
- Lipoprotein synthesis and secretion
- Sirtuins and NAFLD
- Inflammation as it relates to fatty liver disease
- DEUG (Diplome d’Etudes Universitaires Generales), University Blaise Pascal, France, 1986.
- BS, Cell Biology, Metabolic Biochemistry, Animal & Plant Physiology, Microbiology, Virology, Immunology, University Blaise Pascal, France, 1988
- MS, Cell Biology, Genetics, Animal & Plant Biology and Physiology, University Blaise Pascal, France,1989.
- DEA (Diplome d’Etude Approfondies), Molecular and Cell Biology, University Blaise Pascal, France,1990.
- Ph.D. Molecular and Cell Biology, University Blaise Pascal/Institute of Human Nutrition, France, 1994
- Research Assistant Professor, Washington University, Department of Medicine, Geriatrics and Nutritional Sciences, St. Louis, MO, 2006-2013
- Research Instructor, Washington University, Department of Medicine, Geriatrics and Nutritional Sciences, St. Louis, MO, 2004-2006
- Research Instructor, Washington University, Department of Medicine, Gastroenterology, St. Louis, MO,1999-2004
- Research Associate, Washington University, Department of Medicine, Gastroenterology, St. Louis, MO. Supervisor: Nicholas O. Davidson, 1998-1999
- Research Associate, University of Chicago, Department of Medicine Gastroenterology, Chicago, IL: Nicholas O. Davidson, 1996-1998
- Graduate Research Assistant, University Blaise Pascal, France, 1989-1990
- Graduate student, University Blaise Pascal/ Institute of Human Nutrition. INRA/Theix, Clermont-Ferrand, France, Supervisors: Yves Rayssiguier and Andre Mazur, 1989-1994
Honors & Awards
- First prize from French Association of Nutrition (AFN), 1991-1993
- Qualification for Lecturer in cell biology, University Blaise Pascal, Clermont Ferrand, France, 1995-2000
- Fellowship from French Committee of Research on Cholesterol and Atherosclerosis (ARCOL), 1995
- MARC travel Award, 2006
- Poster of distinction at the AGA (American Gastrological Association), 2000
Dr. Nassir’s research interests focuses on understanding the mechanisms involved in the pathogenesis and rescue of non-alcoholic fatty liver disease (NAFLD). In particular, she is interested in the role of mitochondria, sirtuins, inflammation and nutrition as it relates to NAFLD.
Other interests include the regulation of fatty acids uptake as well as the regulation of lipoprotein synthesis and secretion in hepatic and intestinal cells. She uses in vivo as well as in vitro models including primary hepatocytes and enterocytes, and cell lines. Previous research interest includes the role of nutritional status in minerals and oligo-elements in the regulation of hepatic lipid metabolism.
For a full list of publications, click here.
- Nassir F, Rector RS, Hammoud GM, Ibdah JA. Pathogenesis and Prevention of Hepatic Steatosis. Gastroenterology and Hepatology. Gastroenterology & Hepatology 2015, Volume 11: 167-175.
- Nassir F, Ibdah JA. Role of Mitochondria in Nonalcoholic Fatty Liver Disease. Int J Mol Sci. 2014, 15(5):8713-42.
- Nassir F, Ibdah JA. Role of mitochondria in alcoholic liver disease. World J. Gastroenterol. 2014; 20(9):2136-42.
- Abumrad N, Nassir F, Marcus A. Digestion and Absorption of Dietary Fat, Carbohydrate, and Protein. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 10th ed, Feldman M, Friedman LS, Brandt LJ. (Eds), Saunders, Philadelphia 2016. p.17369.
Selected Peer-Reviewed Abstracts
- Nassir, F., Justin J. Arndt and Jamal A. Ibdah. SIRT3 deacetylates the mitochondrial trifunctional protein (MTP) and rescues NAFLD in MTP heterozygous mice. (Oral presentation) The Liver Meeting, 2016 Nov 11 - Nov 15, 2016, Boston MA.
- Nassir, F., Arndt, J.J., Ibdah, J.A. “Hepatic overexpression of SIRT3 in mice heterozygous for mitochondrial trifunctional protein rescues hepatic steatosis and improves insulin sensitivity”. Gastroenterology 148: S973, 2015. (Lecture presentation). Washington, DC, May 16 -19, 2015.
- Nassir F, Arndt JJ, Ibdah JA. Hepatic SIRT3 overexpression induces mitophagy and alleviates hepatic steatosis and insulin resistance in mice heterozygous for mitochondrial trifunctional protein. (Poster presentation) Cell Symposia: Multifaceted Mitochondria. Chicago, July 19-21, 2015.