University of Missouri School of Medicine MU Health School of Medicine
Gast-ibdah-j

Jamal Ibdah, MD, PhD

Professor of Medicine
Professor of Medical Pharmacology and Physiology
Director, Division of Gastroenterology and Hepatology 
Director, Digestive Health Center
Director, Gastroenterology Fellowship Program
Raymond E. and Vaona H. Peck Chair in Cancer Research

Clinical Profile

Clinical and Research Interests

Screening colonoscopy, Gastroenterology, Hepatology

Contact Information

E-mail: ibdahj@health.missouri.edu
Division: Gastroenterology & Hepatology
Clinic Phone: (573) 884-7600
Office Phone: (573) 882-1013
Office Address: DC043.00, 1 Hospital Drive
Columbia, MO

Appointments

  • Director, Division of Gastroenterology and Hepatology (2005-present)
  • Director, Digestive Health Center (2005-present)
  • Senior Associate Dean for Research (2006-2015)
  • Director, MU Institute for Clinical and Translational Science (2006-2015)
  • Director, Gastroenterology Fellowship Program (2005-present)
  • Professor of Medicine (2005-present)
  • Professor of Medical Pharmacology and Physiology (2005-present)
  • Raymond E. and Vaona H. Peck Chair in Cancer Research (2005-present)

Board Certifications

  • Gastroenterology (ABIM)

Fellowship

  • GI/Liver Fellowship, Barnes-Jewish Hospitals, Washington University School of Medicine (St. Louis, MO

Medical School

  • University of Jordan (Amman, Jordan)

Post Graduate Training

  • Ph.D, Biochemistry, Medical College of Pennsylvania (Philadelphia, PA)

Residency

  • North Carolina Baptist Hospital, Wake Forest University (Winston-Salem, NC)

Honors & Awards

  • Fellow, American Gastroenterological Association (AGAF)
  • Fellow, American College of Gastroenterology (FACG)
  • Endowed Chair of Cancer Research
  • Medical Foundation Teaching Scholar Award, Wake Forest University, 1997-1998 and 1998-1999
  • Outstanding Investigator in Clinical Sciences Award, Wake Forest University, 2000

Research Interests

  • To explore the role of genetic and environmental alterations in mitochondrial fatty acid oxidation in development of fatty liver disease in pregnancy, nonalcoholic fatty liver disease, and insulin resistance.
  • To investigate the relationship between lifestyle modifications and nonalcoholic fatty liver disease in animal models and human subjects.
  • Outcomes research in GI malignancies.

For a complete list of publications, click here.

Selected Publications (past three years)

Peer-Reviewed Journal Articles

  1. Linden M.A., Fletcher J.A., Morris E.M., Meers G.M., Kearney M.L., Crissey J.M., Laughlin M.H., Booth F.W., Sowers J.R., Ibdah J.A., Thyfault J.P., Rector R.S. “Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats”. Am. J. Physiol. Endocrinol. Metab. 306: E300-10, 2014. PMID: 24326426, PMCID: PMC3920010
  2. Nassir F., Ibdah J.A. “Role of mitochondria in alcoholic liver disease”. World J. Gastroenterol. 20: 2136-42. PMID: 24605012, PMCID: PMC3942818
  3. Rahman R.N., Asombang A.W., Ibdah J.A. “Characteristics of gastric cancer in Asia”. World J. Gastroenterol. 20: 4483-90, 2014. PMID: 24782601, PMCID: PMC4000485
  4. Asombang A.W., Rahman R.N., Ibdah J.A. “Gastric cancers in Africa: current management and outcomes”. World J. Gastroenterol. 20:3875-9, 2014. PMID: 24833842, PMCID: PMC3983443
  5. Choudhary A., Winn J., Siddique S., Arif M., Arif Z., Hammoud G.M., Puli S.R., Ibdah J.A., Bechtold M.L. “Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis: a systematic review and meta-analysis”. World J. Gastroenterol. 20: 4093-101, 2014. PMID: 24744601, PMCID: PMC3983468
  6. Toedebusch R.G., Roberts M.D., Wells K.D., Company J.M., Kanosky K.M., Padilla J., Jenkins N.T., Perfield J.W. 2nd, Ibdah J.A., Booth F.W., Rector R.S. “Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity”. Physiol. Genomics 46: 362-75, 2014. PMID: 24642759, PMCID: PMC4042183
  7. Nassir F., Ibdah, J.A. “Role of mitochondria in nonalcoholic fatty liver disease”. Int. J. Mol. Sci. 15: 8713-42, 2014. PMID: 24837835, PMCID: PMC4057755
  8. Hammoud G.M., Hammad H., Ibdah J.A. “Endoscopic assessment and management of early esophageal adenocarcinoma”. World J. Gastrointestinal Oncol. 15: 275-88, 2014. PMID: 25132925, PMCID: PMC4133795
  9. Hammoud G.M., Ibdah J.A. “The utility of endoscopic ultrasound in patients with portal hypertension”. World J. Gastroenterol. 20: 14230-6, 2014. PMID: 25339809, PMCID: PMC4202351
  10. Morris E.M., Jackman M.R., Johnson G.C., Liu T.W., Lopez J.L., Kearney M.L., Fletcher J.A., Meers G.M., Koch L.G., Britton S.L., Rector R.S., Ibdah J.A., MacLean P.S., Thyfault J.P. “Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis”. Am. J. Physiol. Endocrinol. Metab. 307: E355-64, 2014. PMID: 24961240, PMCID: PMC4137118
  11. Hammoud G.M., Almashhrawi A.A., Ibdah J.A. “The usefulness of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of hepatic, gallbladder and biliary tract lesions”. World J. Gastrointestinal Oncol. 6: 420-9, 2014. PMID: 25400873, PMCID: PMC4229785
  12. Hammoud G.M., Ibdah J.A. “Preeclampsia-induced Liver Dysfunction, HELLP Syndrome, and Acute Fatty Liver of Pregnancy”. Clinical Liver Disease 4: 69-73, 2014.
  13. Hammoud G.M., Ibdah J.A. “Liver Transplantation”. Greene County Medical Society Journal 72: 6-8, 2014.
  14. Linden M.A., Fletcher J.A., Morris E.M., Meers G.M., Laughlin M.H., Booth F.W., Sowers J.R., Ibdah J.A., Thyfault J.P., Rector R.S. “Treating NAFLD in OLETF rats with vigorous-intensity interval exercise training”. Med. Sci. Sports Exerc. 47:556-67, 2015. PMID: 24983336, PMCID: PMC4280360
  15. Nassir F., Rector R.S., Hammoud G.H., Ibdah J.A. “Pathogenesis and prevention of hepatic steatosis”. Gastroenterol. & Hepatology 11: 167-75, 2015. PMID: 27099587
  16. Shukla S., Restrepo R.J., Fish P., Lim R.W., Ibdah J.A. “Different mechanisms for histone acetylation by ethanol and its metabolite acetate in rat primary hepatocytes”. J. Pharmacol. Exp. Ther. 354:18-23, 2015. PMID: 25886906
  17. Mejia E.M., Ibdah J.A., Sparagna G.C., Hatch G.M. “Differential reduction in cardiac and liver tetralinoleoyl-cardiolipin and monolysocardiolipin acyl transferase-1 in the alpha subunit of trifunctional protein heterozygous knockout mice”. Biochem. J. 471: 123-129, 2015. PMID: 26251360
  18. Linden M.A., Lopez K.T., Fletcher J.A., Morris E.M., Meers G.M., Siddique S., Laughlin H.M., Sowers J.R., Thyfault J.P., Ibdah J.A., Rector R.S. “Combining metformin therapy with caloric restriction in the management of type 2 diabetes and NAFLD in obese rats”. Appl. Physiol. Nutr. Metab. 24: 1-10, 2015. PMID: 26394261
  19. Tahan V., Almashhrawi A., Mutrux R., Ibdah J.A. “Show Me Echo – Hepatitis C: A telemedicine mentoring program for patients with hepatitis C in underserved and rural areas in Missouri as a model in developing countries”. Turk. J. Gastroenterol.  26:447-9, 2015. PMID: 26510085
  20. Shukla S., Aroor A., Restrepo R., Kharbanda K., Ibdah J.A. “In vivo acute on chronic ethanol effects in liver: A mouse model exhibiting exacerbated injury, altered metabolic & epigenetic responses”. Biomolecules 5:3280-94, 2015. PMID: 26610587
  21. Szary N., Rector R.S., Uptergrove G.M., Ridenhour S.E., Shukla S.D., Thyfault J.P., Koch L.G., Britton S.L., Ibdah JA. “High intrinsic aerobic capacity protects against ethanol-induced hepatic injury and metabolic dysfunction: study using high capacity runner rat model”. Biomolecules 5:3295-308, 2015. PMID: 26610588
  22. Rahman R.N., Schmaltz C.L., Jackson C., Simoes E.J., Jackson-Thompson J., Ibdah J.A. “Increased risk for colorectal cancer under age 50 in racial and ethnic minorities living in the United States”. Cancer Med. 4:1863-70, 2015. PMID: 26471963
  23. Hammoud G.M., Ibdah J.A. “Are we getting closer to understanding intratumor heterogeneity in hepatocellular carcinoma?”. Hepatobiliary Surg. Nutr. 5:188-90, 2016. PMID: 27115014; PMCID: PMC4824738
  24. Linden M.A., Sheldon R.D., Meers G.M., Ortinau L.C., Morris E.M., Booth F.W., Kanaley J.A., Vieira-Potter V.J., Sowers J.R., Ibdah J.A., Thyfault J.P., Laughlin M.H., Rector R.S. “Aerobic exercise training in the treatment of NAFLD related fibrosis”. J Physiol. 594:5271-84, 2016. PMID: 27104887
  25. Tahan V., Almashhrawi A., Kahveci A.M., Mutrux R., Ibdah J.A. “Extension for Community Health Outcomes-hepatitis C: Small steps carve big footprints in the allocation of scarce resources for hepatitis C virus treatment to remote developing areas”. World J Hepatol. 8:509-12, 2016. PMID: 27099651; PMCID: PMC4832092
  26. Winn N.C., Liu Y., Rector R.S., Ibdah J.A., Parks E.J., Kanaley J.A. “Moderate and high intensity exercise training matched for energy expenditure reduces intrahepatic lipid in obese individuals with hepatic steatosis”. Med Sci Sports Exerc. 48: 909, 2016. PMID: 27361758
  27. Sathyamurthy A., Winn J.N., Ibdah J.A., Tahan V. “Culprit for recurrent acute gastrointestinal massive bleeding: “Small bowel Dieulafoy’s lesions” – a case report literature review”. World J Gastrointest Pathophysiol. 15: 296-9, 2016. PMID: 27574568
  28. Morris E.M., Meers G.M., Koch L.G., Britton S.L., Fletcher J.A., Shankar K., Fu X., Burgess S.C., Ibdah J.A., Rector R.S., Thyfault J.P. “Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high fat diet induced hepatic steatosis”. Am J Physiol Endocrinol Metab. 2016. [Epub ahead of print] PMID: 27600823

Book Chapters

  1. Hammoud, G.M., Almashhrawi, A.A., Ahmed, K.T., Rahman, R., Ibdah, J.A. Liver diseases in pregnancy: liver transplantation in pregnancy. In: World Clinical Gastroenterology (1st ed). Ma L, Chua MS, So S (eds). 2014 (ISBN 978-0-9914430-0-0).
  2. Ahmed, K.T., Almashhrawi, A.A., Rahman, R.N., Hammoud, G.M., Ibdah, J.A. Liver diseases in pregnancy: diseases unique to pregnancy. In: World Clinical Gastroenterology (1st ed). Ma L, Chua MS, So S (eds). 2014 (ISBN 978-0-9914430-0-0).
  3. Almashhrawi, A.A., Ahmed, K.T., Rahman, R.N., Hammoud, G.M., Ibdah, J.A. Liver diseases in pregnancy: diseases not unique to pregnancy. Liver diseases in pregnancy: diseases unique to pregnancy. In: World Clinical Gastroenterology (1st ed). Ma L, Chua MS, So S (eds). 2014 (ISBN 978-0-9914430-0-0).
  4. Rahman, R., Hammoud, G.M., Almashhrawi, A.A., Ahmed, K.T., Ibdah, J.A. Primary hepatocellular carcinoma and metabolic syndrome: An update. In: World Clinical Gastroenterology (1st ed). Ma L, Chua MS, So S (eds). 2014 (ISBN 978-0-9914430-0-0).
  5. Khare, S., Zhang, Q., Ibdah, J.A. Epigenetics of hepatocellular carcinoma: role of microRNA. In: World Clinical Gastroenterology (1st ed). Ma L, Chua MS, So S (eds). 2014 (ISBN 978-0-9914430-0-0).

Selected Peer-Reviewed Abstracts

  1. Bechtold M.L., Asombang A., Madsen R., Simuyandi M., Phiri G., Ibdah J.A., Lishimpi K., Banda L. “Colorectal Cancer: Descriptive Analysis Comparing a Native African Population to an African American Population”. ACG P2142, 2016.
  2. Bechtold M.L., Asombang A., Madsen R., Simuyandi M., Phiri G., Ibdah J.A., Lishimpi K., Banda L. “Pancreatic Cancer: Patterns in a Low to Middle Income Population, Zambi”. ACG P2143, 2016.
  3. Rahman, R.N., Ibdah, J.A. “Racial disparities and trend analysis of gastric cancer in the USA: A 1973-2010 population-based study”. Gastroenterology 146: S169, 2014.
  4. Linden, M.A., Lopez, K.T., Fletcher, J., Meers, G.M., Saddique, S., Morris, M., Laughlin, M.H., Sowers, J., Thyfault, J.P., Ibdah, J.A., Rector, R.S. “Combination therapy of metformin and caloric restriction in the treatment of type 2 diabetes and NAFLD in OLETF rats”. International Journal of Exercise Science: Conference Proceedings 11:50, 2014.
  5. Linden, M.A., Lopez, K.T., Fletcher, J., Meers, G.M., Saddique, S., Morris, M., Laughlin, M.H., Sowers, J., Thyfault, J.P., Ibdah, J.A., Rector, R.S. “Improved efficacy of metformin therapy when combined with caloric restriction in the treatment of type 2 diabetes and NAFLD in OLETF rats”. The FASEB Journal 28: LB743, 2014.
  6. Rahman, R.N., Ibdah, J.A. “A four-decades epidemiological study of pancreatic cancer in the USA: Increasing incidence in recent years”. Gastroenterology 146: S692, 2014.
  7. Nassir, F., Arndt, J.J., Ibdah, J.A. “Hepatic overexpression of SIRT3 in mice heterozygous for mitochondrial trifunctional protein rescues hepatic steatosis and improves insulin sensitivity”. Gastroenterology 148: S973, 2015.
  8. Khare, T., Mooney, B., Ridenhour, S.E., Lowery, R., Khare, S., Ibdah, J.A. “A mitochondrial fatty acid oxidation defect causes hepatic steatosis and susceptibility for hepatocellular carcinoma: A proteomics approach”. Gastroenterology 148: S1016, 2015.
  9. Nassir, F., Arndt, J.J., Ibdah, J.A. “Hepatic SIRT3 overexpression induces mitophagy and alleviates hepatic steatosis and insulin resistance in mice heterozygous for mitochondrial trifunctional protein”. Cell Symposia: Multifaceted Mitochondria, 2015.
  10. Rahman, R.N., Schmaltz, C., and Ibdah J.A. “Increasing incidence of anal cancer in major U.S. ethnic/racial groups: A SEER database study 1973-2011”. Am. J. Gastroenterol. 110: S944, 2015.
  11. Winn, N.C., Liu, Y., Rector, R.S., Ibdah, J.A., Parks, E.J., Kanaley, J.A. Moderate and high intensity exercise training matched for energy expenditure reduces intrahepatic lipid in obese individuals with hepatic steatosis. Med Sci Sports Exerc. 48: 909, 2016.
  12. Linden M.A., Sheldon R.D., Meers G.M., Ortinau L.C., Morris E.M., Vieira-Potter V.J., Kanaley J.A., Booth F.W., Sowers J.R., Ibdah J.A., Thyfault J.P., Laughlin M.H., Rector R.S. Exercise training as a mitigator of liver fibrosis in western diet fed OLETF rats. Med Sci Sports Exerc. 48: 485 (5S Suppl 1), 2016. PMID: 27584362
  13. Panasevich M.R., Linden M.A., Meers G.M., Kanosky K.M., Reubel M., Perfield J.W., Booth F.W., Ibdah J.A., Oerther D.B., Rector R.S. Cecal Microbiota Dysbiosis and Hepatic Transcriptomic Alterations in Western Diet-Induced NASH in Juvenile Ossabaw Swine. FASEB Journal, Suppl 2016.

For a complete list of publications, click here.

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