University of Missouri School of Medicine MU Health School of Medicine
sowers-2013

James R. Sowers, MD

Professor of Medicine

Clinical Profile

Clinical and Research Interests

Diabetes, Cardiac Rehabilitation, Cardiovascular Diseases, Lipid Disorders, Metabolism, Preventive Health, Endocrine Disorders

Contact Information

E-mail: sowersj@health.missouri.edu
Division: Endocrinology
Office Phone: (573) 882-3818
Office Address: DC043.00, 1 Hospital Drive
Columbia, MO

Appointments

  • 2007-present: Thomas W. and Joan F. Burns Missouri Chair in Diabetology
  • 2007-present: Director, Center for Diabetes and Cardiovascular Research, Columbia, Missouri
  • 2007-present: Director, Division of Endocrinology, Diabetes & Metabolism, University of Missouri-Columbia, Columbia, Missouri
  • 2007-present: Vice-Chair for Research, Department of Internal Medicine, University of Missouri-Columbia, Columbia, Missouri
  • 2007-present: Professor of Medicine, Physiology & Pharmacology, University of Missouri-Columbia, Missouri
  • 2007-present: Staff Physician, Medical Service, H.S. Truman VAMC, Columbia, Missouri 1976-1978 Assistant Professor, University of Missouri-Kansas City, School of Medicine
  • 2006-2007: Professor of Medicine and Physiology, Director of Diabetes, Hypertension and Metabolism Research, University of Arizona, Tucson, Arizona
  • 2006-2007: Professor of Medicine and Physiology, Director of Diabetes, Hypertension and Metabolism Research, University of Arizona, Tucson, Arizona
  • 2003-2006: Vice Chair of Research, Dept of Internal Medicine, University of Missouri-Columbia, Columbia, Missouri
  • 2003-2006: Director, Diabetes and Cardiovascular Disease Center, Columbia, Missouri
  • 2003-2006: Professor of Medicine, Physiology & Pharmacology, University of Missouri-Columbia, Missouri
  • 2003-2006: Staff Physician, Medical Service, H.S. Truman VAMC, Columbia, Missouri
  • 1999-2003: Chief, Endocrinology, Diabetes and Hypertension, SUNY HSC at Brooklyn, New York
  • 1999-2003: Staff Physician, Medical Service VAMC, Brooklyn, New York
  • 1984-1999: Director, Division of Endocrinology, Metabolism and Hypertension, Wayne State University, Detroit, Michigan
  • 1984-1999: Professor of Medicine and Physiology, Wayne State University School of Medicine
  • 1984-1999: Staff Physician, Medical Service VAMC, 4646 John R, Detroit, MI 1979-1983 Assistant Chief, Endocrinology - Metabolism, UCLA San Fernando Valley Program
  • 1983-1984: Chief of Endocrinology and Hypertension, McGuire Veterans Administration Medical Center, Richmond, Virginia
  • 1983-1984: Associate Professor of Medicine, Medical College of Virginia
  • 1979-1983: Associate Professor of Medicine UCLA
  • 1979-1983: Chief, Neuroendocrine Labs, UCLA, San Fernando Valley Program

Board Certifications

  • 1977: American Board of Internal Medicine, Subspecialty, Endocrinology, Diabetes and Metabolism
  • 1974: American Board of Internal Medicine

Committee Service

  • Charter Member VCMB Study Section – NIH – 2010-present
  • American Heart Association - Cardiovascular and Renal Study Section (1989-1994) (2008-present)
  • AHA Council for High Blood Pressure (2007-2010)
  • Scientific Oversight committee – NIH-ACCORD Trial (2004-2009)
  • VA Merit Review Board - Endocrinology (1990-1994) (2006-present)
  • SAS, Truman VA Hospital (2004-2007)
  • ACORP, Truman VA Hospital (2004-2007)
  • Admissions Committee, University of Missouri School of Medicine (2004-2006)
  • Chairman, Promotion and Tenure Committee, University of Missouri School of Medicine (2004-2006)
  • NIH Cardiovascular Sections, Ad Hoc Reviewer (1989-1997) (2001-2006)
  • American Society of Hypertension Executive Council (1999-2005)
  • NIH GCRC Site Visits (1991-1994) (2002-2003)
  • Chair of Brooklyn Manhattan VA, R & D (2001-2003)
  • NIH Experimental Cardiovascular Sciences Study Section Member (1996-2001)
  • Co-Chair ISHIB International Conference (1998)
  • US-Israel Binational Science Foundation - Grant Reviewer (1985-1997)
  • Cardiovascular Regulation Research Study Committee, AHA (1990-1993)
  • Chairman, NIH Consensus on Hypertension and Diabetes (1993)
  • NIH Joint National Committee for Blood Pressure (JNC 6 and 7)
  • NDC-Nutrition Research Science Advisory Committee Member/Reviewer (1989-1992)
  • Chairman, Promotion and Tenure Committee, WSU School of Medicine (1990-1991)
  • Wayne State University Executive Committee (1989-1991)
  • Consultant NIH Study Section for (SCOR) Hypertension Grants (1989-1990)

Doctoral Essays/Theses/Dissertations directed

  • Paul Standley, Ph.D. thesis, Insulin and Hypertension
  • Feng Zhang, Ph.D. thesis, Sex Hormones and Vascular Calcium Currents.
  • Ranganath Muniyappa PhD Thesis, Signal Transduction Mechanisms Mediating IGF-1 Induced Nitric Oxide Release in Endothelial Cells

Fellowship

  • 1974-1976: Fellowship in Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Los Angeles, California and Wadsworth Veterans Administration Medical Center

Medical School

  • 1967-1971: MD, University of Missouri

Residency

  • 1971-1974: Residency in Internal Medicine, University of Alabama Hospitals and Clinics and St. John's Mercy Medical Center, St. Louis, Missouri

Teaching

  • UCLA School of Medicine, Los Angles, California – 1979-1983
  • Medical College of Virginia, Richmond, Virginia – 1983-1985
  • Wayne State University, Detroit, Michigan – 1985-1999
  • SUNY Downstate- Brooklyn, New York – 1999-2003
  • University of Missouri – 1976-1979, 2003-present

University Activities

  • Internal Medicine Clerkship student preceptor

Honors & Awards

  • 2010: Seale Harris Research Award, Southern Medical Association
  • 2010: Fellow in the American Society of Hypertension
  • 2008: University of Missouri, Medical Alumni Organization Citation of Merit
  • 2008: Alpha Omega Alpha Honor Medical Society Inductee
  • 2006: Midwestern Outstanding Research award of AHA
  • 1989: Detroit Federal Executive Board-Distinguished Scientist
  • 1986: Distinguished Teacher of Department of Medicine, Wayne State University
  • 1970: Lange Medical Award for Scholastic and Research Achievement

Professional Societies

  • American Society Clinical Investigation
  • Alpha Omega Alpha, Honor Medical Society
  • American Physiology Society
  • Society of Vascular Medicine
  • American Federation of Clinical Research
  • Fellow, High Blood Pressure Council
  • American College of Physicians
  • Endocrine Society
  • American Diabetes Association
  • American Society of Hypertension
  • American College of Physicians (Fellow)
  • Southern, Western, and Central Society of Clinical Investigation
  • International Society of Hypertension
  • International Society of Hypertension in Blacks
  • Inter-American Society of Hypertension

Grant Support

  • 2011-2016: NHLBI, Ang II and Overnutrition and Insulin resistance in Cardiovascular Tissue, James R. Sowers (PI), $1,250,000.
  • 2009-2014: NHLBI, Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular Tissue, James R. Sowers (PI), $1,250,000.
  • 2008-2012: VA Merit Review, Mechanisms of Angiotensin II and Aldosterone Inhibition of Insulin Metabolic Signaling, James R. Sowers (PI), $650,000.
  • 2006-2009: Department of Health & Human Services, Beta-Oxidation and Susceptibility to Fatty Liver Disease, Jamal Ibdah, (PI), James R.Sowers (Co-PI), $200,000.
  • 2006-2009: Department of Health & Human Services, Beta-Oxidation and Susceptibility to Fatty Liver Disease, Jamal Ibdah, (PI), James R.Sowers (Co-PI), $200,000.
  • 2005-2008: NIDDK, Immune Tolerance Against Type I Diabetes in Mice, Habib Zaghouani (PI), James R. Sowers (Co-PI), $175,000.
  • 2004-2009: VA Merit Review, Vascular Protein Kinase B/Akt and Rho Signaling: Interactions of IGF-1 and Ang II, James R. Sowers (PI), $135,000.
  • 2004-2009: NIDDK, From Clinic to Bench and Back: Clinical Biodetective Training, Mark Milanick (PI), James R. Sowers (Co-PI), $162,579.
  • 2004-2008: NHLBI, Ang II Opposes INS Mediated Vasorelaxation and GLU Utilization, James R. Sowers (PI), $200,000.
  • 2004-2008: NIH/NHLBI, University of Iowa, Circumventricular Organs: Gender and Hypertension, Meredith Hay (PI), James R. Sowers (Co-PI), $34,000.
  • 2004-2006: NHLBI, Cardiovascular and Renal Physiology, Pharmacology and Biochemistry, Virginia Huxley (PI), James R. Sowers (CoPI), $266,599.
  • 2000-2003: ADA, Vascular Interactions of Estradiol and Insulin-Like Growth Factor: Impact of Insulin Resistance and Hypertension, James R. Sowers (PI), $299,997.
  • 1999-2004: NIH, Ang II and IGF-1 Interaction in Cardiovascular Tissue, James R. Sowers (PI), $982,361.
  • 1999-2002: VA Merit Review, Vascular Action of Insulin and IGF-1: PI3-Kinase Related Resistance. James R. Sowers (PI), $450,000.
  • 1994-1999: VA Merit Review, Actions of Insulin and IGF-I on Vascular Smooth Muscle Cation and Glucose Metabolism, James R. Sowers (PI), $569,800.
  • 1994-1999: Department of Veteran's Affairs vanguard site in the Antihypertensive and Lipid-Lowering Therapy to Prevent Heart Attack Trial (ALLHAT) sponsored by National Heart, Lung, and Blood Institute and DVA. James R. Sowers (PI), $159,000.
  • 1990-1994: VA Merit Review, Insulin Resistance and Hypertension, James R. Sowers (PI), $320,000.
  • 1990-1993: NIH, Health Promotion and Disease Prevention, Waller (PI), James R. Sowers (Co-PI), $1,460,457.
  • 1987-1996: NIH, Insulin Resistance & Altered Cellular Calcium Metabolism in Pregnancy, James R. Sowers (PI).
  • 1980-1990: NIH and VA

Journal Articles (20 most recent out of 400)

  • Figueroa SC, Khan U, Kurukulasuriya LR, Gardner D, Sowers JR. Surgical Cure of Hypertension in a Patient With MEN 2A Syndrome and Mixed Dopamine, Metanephrine Pheochromocytoma. J Clin Hypertens (Greenwich). 2010;12(6):439-43.
  • Weir MR, Zappe D, Orloski LA, Sowers JR. How early should blood pressure control be achieved for optimal cardiovascular outcomes? J Hum Hypertens. 2010; Jul 1. [Epub ahead of print].
  • Lastra G, Dhuper S, Johnson MS, Sowers JR. Salt, aldosterone, and insulin resistance: impact on the cardiovascular system. Nat Rev Cardiol. 2010;7:577-584.
  • Bakris G, Vassalotti J, Ritz E, Wanner C, Stergiou G, Molitch M, Nesto R, Kaysen GA, Sowers JR. National Kidney Foundation consensus conference on cardiovascular and kidney diseases and diabetes risk: an integrated therapeutic approach to reduce events. Kidney Int. 2010;78(8):726-36.
  • Ren J, Pulakat L, Whaley-Connell A, Sowers JR. Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med. 2010;88(10):993-1001.
  • Kurukulasuriya LR, Sowers JR. Therapies for type 2 diabetes: lowering HbA1c and associated cardiovascular risk factors. Cardiovasc Diabetol. 2010;9(1):45.
  • Bomback AS, Rekhtman Y, Whaley-Connell AT, Kshirsagar AV, Sowers JR, Chen SC, Li S, Chinnaiyan KM, Bakris GL, McCullough PA. Gestational diabetes alone, in the absence of subsequent diabetes, is associated with microalbuminuria: results from the Kidney Early Evaluation Program (KEEP). Diabetes Care. 2010;Aug 31. [Epub ahead of print].
  • Varagic J, Ahmad S, Brosnihan KB, Habibi J, Tilmon RD, Sowers JR, Ferrario CM. Salt-Induced Renal Injury in Spontaneously Hypertensive Rats: Effects of Nebivolol. Am J Nephrol. 2010;32(6):557-566.
  • Oparil S, Giles T, Ofili EO, Pitt B, Seifu Y, Hilkert R, Samuel R, Sowers JR. Moderate versus intensive treatment of hypertension with amlodipine/valsartan for patients uncontrolled on angiotensin receptor blocker monotherapy. J Hypertens. 2010 Oct 30. [Epub ahead of print].
  • Whaley-Connell A, Sowers JR. Is it Time to Target Prehypertension. Cardiovasc Ther. 2010;28(6):337-8.
  • Demarco VG, Johnson MS, Habibi J, Pulakat L, Gul R, Hayden MR, Tilmon R, Dellsperger KC, Winer N, Whaley-Connell AT, Sowers JR. Comparative Analysis of Telmisartan and Olmesartan on Cardiac Function in the TG(mRen2)27 Rat. Am J Physiol Heart Circ Physiol. 2010 Nov 5. [Epub ahead of print].
  • Siyam F, Brietzke SA, Sowers JR. Resistant hypertension in office practice: a clinical approach. Hosp Pract (Minneap). 2010;38(4):90-7.
  • Hayden MR, Yang Y, Habibi J, Bagree SV, Sowers JR. Pericytopathy: Oxidative stress and impaired cellular longevity in the pancreas and skeletal muscle in metabolic syndrome and type 2 diabetes. Oxid Med Cell Longev. 2010 Sep 1;3(5).
  • Demarco VG, Whaley-Connell AT, Sowers JR, Habibi J, Dellsperger KC. Contribution of oxidative stress to pulmonary arterial hypertension. World J Cardiol. 2010 Oct 26;2(10):316-24.
  • Habibi J, Hayden MR, Sowers JR, Pulakat L, Tilmon RD, Manrique C, Lastra G, Demarco VG, Whaley-Connell A. Nebivolol Attenuates Redox-Sensitive Glomerular and Tubular Mediated Proteinuria in Obese Rats. Endocrinology. 2010 Dec 22. [Epub ahead of print].
  • McCullough PA, Whaley-Connell A, Brown WW, Collins AJ, Chen SC, Li S, Norris KC, Jurkovitz C, McFarlane S, Obialo C, Sowers J, Stevens L, Vassalotti JA, Bakris GL. Cardiovascular risk modification in participants with coronary disease screened by the Kidney Early Evaluation Program. Intern Med J. 2010 Dec;40(12):833-41.
  • Habibi J, Demarco VG, Ma L, Pulakat L, Rainey WE, Whaley-Connell AT, Sowers JR. Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in transgenic model of RAAS overexpression. Am J Physiol Heart Circ Physiol. 2011 Jan 14. [Epub ahead of print]
  • Yang Y, Hayden MR, Sowers S, Bagree SV, Sowers JR. Retinal redox stress and remodeling in cardiometabolic syndrome and diabetes. Oxid Med Cell Longev. 2010 Nov 1;3(6):392-403.
  • CCORD Study Group, Gerstein HC, Miller ME, Genuth S, Ismail-Beigi F, Buse JB, Goff DC Jr, Probstfield JL, Cushman WC, Ginsberg HN, Bigger JT, Grimm RH Jr, Byington RP, Rosenberg YD, Friedewald WT. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med. 2011 Mar 3;364(9):818-28.
  • Giles TD, Oparil S, Ofili EO, Pitt B, Purkayastha D, Hilkert R, Samuel R, Sowers JR. The role of ambulatory blood pressure monitoring compared with clinic and home blood pressure measures in evaluating moderate versus intensive treatment of hypertension with amlodipine/valsartan for patients uncontrolled on angiotensin receptor blocker monotherapy. Blood Press Monit. 2011 Apr;16(2):87-95.

Books

  • Hypothalamic Hormones, Editor JR Sowers. Dowden, Hutchinson & Ross Inc. Stroudsberg, PA, Nov. P:342, 1980.
  • The Endocrinology of Aging, JR Sowers and J Felicetta, ed. Raven Press, New York, 1988.
  • Hypertension Primer, JL Izzo, HR Black ed. TL Goodfriend, JR Sowers, FH Messerli, JA Cutler, SG Sheps, D Vidt, section eds. From the Council on High Blood Pressure, American Heart Association, Dallas, Texas, 1993.
  • Contemporary Endocrinology: Endocrinology of the Vasculature. JR Sowers (ed), Humana Press, Totowa, NJ, 1996.
  • Recent Advances in Geriatrics; M Barbagallo, G Licata and JR Sowers eds. Plenum Press, New York , NY; 1998.
  • Hypertension Primer (3rd Edition) The Essentials of High Blood Pressure. Section Editors: TL Goodfriend, JR Sowers, AB Weder, LJ Appel, DG Vidt, SG Sheps, DA Sica. Senior Editors: JL Izzo, Jr, HR Black. American Heart Association. Lippincott Williams & Wilkins, Philadelpha, PA, 2003.
  • Molecular Mechanisms in Hypertension. RN Re, DJ DiPette, EL Schiffrin, JR Sowers Taylor & Francis Group, London and New York, 2006.
  • Diabetes and Hypertension: Moser M, Sowers JR 2005; 2008
  • Hypertension and Cardiovascular Disease. A Whaley-Connell, K Sowers, JR Sowers. Contemporary Diabetes: The Diabetic Kidney. Humana Press Inc., Totowa, NJ, 2006.
  • Diabetes in Women, Pathophysiology and Therapy. Cardiovascular Disease in Women with Diabetes. Gajula S, Reddy A, Kurukulasuriya LR, Manrique C, Lastra G, Sowers JR. Humana Press Inc., Springer Science+Business Media LLC, New York, New York, 2009.

Review Articles

  • Over 140

Book Chapters

  • Ali SS, Lester MA, Sowers JR. Metabolic abnormalities in Hypertension. In: Pathophysiology. 2000, pp110-118.
  • Guzmán CB, Sowers JR. Medical consequences of obesity in women In: Infertility and Reproductive Medicine Clinics of North America. Kowalczyk, C (ed). W.B. Saunders, Philadelphia, PA 2000, pp 1047-9422.
  • Sowers JR, Neutel JM, Weir MR. Diuretics in hypertension therapy. In: Hypertension Medicine. Weber MA (ed). Humana Press, Totowa, NJ 2000, pp. 285-288.
  • Sowers KMR, Sowers JR. Diabetes and hypertension. In: Hypertension Medicine. Weber MA (ed). Humana Press, Totowa, NJ 2000, pp. 375-381.
  • Sowers JR. Diabetes and hypertension. In: Contemporary Cardiology: Diabetes and Cardiovascular Disease. Edited by M.T. Johnstone and A. Veves. Humana Press, Totowa, NJ, 2001, pp123-129
  • Sowers KM, Sowers JR. Pheochromocytomas. In: Manual of Endocrinology and Metabolism (3rd edition). Editor Lavin N. Llilppincott Williams & Wilkins, Philadelphia, PA. 2002, pp139-144.
  • Victorina WM, Rydstedt LL, Sowers JR. Clinical disorders of vasopressin. In: Manual of Endocrinology and Metabolism (3rd edition). Editor Lavin N. Llilppincott Williams & Wilkins, Philadelphia, PA. 2002, pp 68-82.
  • Stern N, Sowers J, Tuck ML. Pathophysiology of hypertension in diabetes. In: Diabetes Mellitus (3rd edition). Editor LeRoith D, Taylor SI, Olefsky JM. Lippincott Williams & Wilkins, Philadelphia, PA. 2004, pp 1377-1400.
  • McFarlane S, Castro J, Kirpichnikov D, Sowers J, Hypertension in Diabetes Mellitus. In: Joslin's Diabetes Mellitus (14th edition). Editor Joanne (Bonnie) Boehme Nesbitt Graphics, Washington, PA. 2004, pp 969-974.
  • A Messerli, E Grossman, J Sowers, F Messerli. Textbook of Cardiovascular Medicine. Lippincott Williams & Wilkins, New York, 2004.
  • Stas S, McFarlane S, Sowers JR. Management of Hypertension in Cardiometabolic Syndrome and Diabetes with Associated Nephropathy. In: Hypertension Principles and Practice. Taylor and Francis, Boca Raton, FL. 2005, pp 631-650.
  • Tan AS, Brietzke SA, Gardner DW, Sowers JR. Obesity, Diabetes, and Hypertension. In: Obesity and Diabetes. Humana Press, Totowa, New Jersey. 2006, pp 169-192.
  • McFarlane S, Sica D, Sowers JR. Stroke in patients with diabetes and hypertension. In: The Year In Hypertension. Atlas Medical Publishing, Oxford, UK. 2006, pp 235-248.
  • Sowers J, Khan U, Dawood- Farah F, Kurukulasuriya LR. Hypertension. In: Winn H, Dellsperger K, ed. Cardiovascular Disease in Women. Informa Healthcare; 2006:9-34.
  • Whaley-Connell AT, Sowers JR, Hypertension Primer: Essentials in High Blood Pressure, chapter 47, 2007.
  • Mugo MN, Link D, Stump C, Sowers JR. Insulin Resistance and Diabetes in Hyptertension. In: Comprehensive Hypertension. Mosby. 2007, pp 681-692.
  • Kurukulasuriya LR, Sowers J. Renin Angiotensin System. In: Fonseca V, ed. Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads. Humana Press; 2008:121-147
  • Gajula S, Reddy A, Kurukulasuriya LR, Manrique C, Guido L, Sowers J. Cardiovascular Disease in Women with Diabetes. In: Tsatsoulis A, Wyckoff J, Brown FM, ed. Diabetes in Women. Totowa, NJ: Humana Press; 2009:35-56.

Published Abstracts

  • Over 800
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