University of Missouri School of Medicine MU Health School of Medicine

Current Research

Pradeep Sahota, MD, FAAN, FANA, FAASM, FAES, FACP

Dr. Sahota has participated in more than 40 clinical research studies mostly with external funding, more than 50 peer-reviewed publications, more than 80 abstracts and paper presentations, and several book chapters. He is co-editor of book on sleep disorders. Dr. Sahota served as site reviewer for accreditation of  a sleep center, and has served as an ad-hoc reviewer for several journals. He won multiple awards for excellence in teaching including the Best Neuroscience Teacher award, MUlation award (to honor teachers that MU medical student choose to emulate) and the Order of Socrates.
Dr. Sahota served in various institutional, state, national and international bodies – most in neurology and sleep medicine; selected ones include: Accreditation council of UCNS (United commission for Neurologic subspecialties); Program Accreditation and Development subcommittee of AAN (member, chair); Education Committee of AAN (member); Board of Governors - University of Missouri Medical Alumni Association; Sleep research group of World Federation of Neurology (served as Chair, currently member); Association of Indian Neurologists in America (AINA; member and President). Dr. Sahota is humbled that a contribution was made to AAN foundation recently by one of his previous residents to honor him. He is privileged to have had such trainees who think of him in those terms and support the mission of Neurology and AAN.

Mahesh Thakkar, PhD

The Basic Sleep Research Division at the Department of Neurology is located in the Harry S. Truman Memorial Veterans Hospital. NIH funded projects currently investigate the neural regulation of the sleep-wakefulness cycle, neurobiology of sleep loss and sleep disorders. These projects seek to understand the neurobiological and behavioral consequences of sleep loss using rodents as animal models. Sleep disorders affect a significantly large percentage of the population. Excessive daytime sleepiness, a shared symptom of chronic sleep loss impairs occupational performance and safety, as well as impacting on general health and the quality of life. An understanding of how the brain regulates natural sleep and responds to sleep loss holds the promise of providing a basis for the development of treatments for sleep disorders such as sleep apnea, narcolepsy, and insomnia. Basic research on endogenous neural sleep factors, such as adenosine, could lead to a new generation of medications to treat insomnia or, conversely, promote attention & vigilance. The laboratory uses diverse methods to address these questions, including molecular/biochemical, electrophysiological and behavioral approaches.

David Beversdorf, MD

  • The relationship between serotonin polymorphisms and prenatal stressors in children with autism as compared to Down syndrome and normal children.
  • Rodent model of the effect of prenatal stress on social behavior.
  • Noradrenergic modulation of cognitive flexibility in autism.
  • fMRI demonstration of noradrenergic modulation of functional connectivity in autism.
  • fMRI demonstration of functional connectivity in cocaine withdrawal.
  • Stress-related genes and cognitive effects of stress and PTSD.
  • Mulitelectrode array research into human cognition and epilepsy.
  • fMRI correlates of treatment response in mild cognitive impairment.

 

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