University of Missouri School of Medicine MU Health School of Medicine
News Divider

Translational Research Recognized

MD-PhD student hopes gene therapy discoveries will help children with Duchenne muscular dystrophy

For those who suffer from debilitating genetic disorders, the rapidly developing world of gene therapy research offers new hope for a cure. Three years ago, the seemingly limitless potential of this research led medical student Brian Bostick to study how to deliver missing genes to patients.

"Gene therapy is a technology that opens the door for treatment of a variety of diseases," Bostick said. "It could allow us to target a disease at the level where the defect is located, which is very exciting."

Brian Bostick
Bostick, an MD-PhD graduate student at the University of Missouri, was selected to present his research at the annual meeting of the American College of Physicians (ACP) in April 2010 in Toronto. Bostick's research focuses on finding treatment for a disease that has no known cure — Duchenne muscular dystrophy (DMD). His entry was one of two chosen for oral presentation among 32 entries in the basic science category of the ACP National Medical Students Abstract Competition.

Due to progressive muscle deterioration, children with muscular dystrophy become paralyzed and usually die of respiratory or cardiac failure before their 30th birthday. Approximately 250,000 people in the United States have some form of muscular dystrophy, and DMD is the most common type of the disease, predominantly affecting males.

Bostick has been studying under the guidance of Dongsheng Duan, PhD, Margaret Proctor Mulligan Distinguished Professor in Medical Research in the Department of Molecular Microbiology and Immunology and recipient of the 2009 Chancellor's Award for Outstanding Research and Creative Activity.

"Brian's muscular dystrophy work serves as an outstanding example of the kind of translational research training we are giving our MD-PhD students," Duan said. "We are really working to translate basic science research into the clinical practice, and I believe that is going to change the thinking on how many diseases are treated."

Duan is leading research to develop a new therapy delivery method (viral gene therapy) for DMD patients, which he has tested in mice and now dogs. Unlike other methods, Duan's is effective for both skeletal muscles, such as those in the arms and legs, and cardiac muscles. It has been shown to reach every muscle in large animals.

Bostick is a student in the MU Molecular Microbiology & Immunology – Veterinary Pathobiology Graduate Program and a student in the Tom and Anne Smith MD-PhD Program. He plans to complete a residency in internal medicine at the MU School of Medicine and a postdoctoral research fellowship.
MU Health Magazine


News and Events

David Chang Grill with Caution
Wire bristles from barbecue brushes can cause serious injuries
Tahir Rahman Extreme Beliefs Often Mistaken for Insanity, New Study Finds
Researchers say new term offers more precise definition of non-psychotic behaviors
Paul Tatum Family Medicine Professor Wins Distinguished Physician Award
Tatum recognized for outstanding care of patients near the end of life
Seth Sherman Minimally Invasive Tendon Repair Technique Supports Knee Movement Sooner after Surgery
Researchers found suture anchors, a less-invasive repair technique, responded better to strength-testing after surgery
2016 Graduation MU School of Medicine Awards 86 Medical Degrees at Commencement Ceremony
The graduates will go on to receive additional training as resident physicians in their chosen specialties
Patrice Delafontaine MU School of Medicine Dean Inducted into Prestigious Medical Society
Delafontaine joins elite group of physicians in American Clinical and Climatological Association
Steven Zweig MU Family Medicine Ranked Among Nation’s Best by U.S. News & World Report
Department has been in top 10 for 23 consecutive years
Uzma Khan MU Initiative Helps Rural Doctors Treat Chronic Pain
Show-Me ECHO to offer special training session April 28
Legacy Teachers MU School of Medicine Program Expands to Other Medical Schools
MU’s Legacy Teachers program lets students recognize patients as educators
Susan Nagel Oil and Gas Wastewater Disposal May Increase Endocrine Disrupting Activity
Scientists draw conclusions after study at natural gas and oil extraction wastewater disposal facility
St. Baldricks 2016 Participants Go Bald for Childhood Cancer Research
Community donates more than $40,000 to the cause

Media Relations
University of Missouri Health System
One Hospital Drive, DC028.00
Columbia, MO 65212
24/7 on-call pager: (573) 876-0708

Mary Jenkins
(573) 882-7299

Jeff Hoelscher
(573) 884-1608

Derek Thompson
(573) 882-3323

Diamond Dixon
(573) 884-7541

Justin Kelley (Photographer)
(573) 882-5786
Pager (573) 397-9289

Web Communications
University of Missouri Health System
One Hospital Drive, MA204G, DC018.00
Columbia, MO 65212
(573) 884-0298

Jennifer Orford
(573) 882-0298

Deidra Ashley
(573) 884-3988

Jesslyn Chew
(573) 884-2891

Velvet Hasner
(573) 884-1115

Justin Willett
(573) 884-7740

Printer Friendly
Follow us on Twitter!   Facebook   YouTube Videos   Instagram   Pinterest  
Website created and maintained by the Office of Communications. Contact the MU School of Medicine.
Revised: April 27, 2013 - Copyright © 2014 - Curators of the University of Missouri. All rights reserved. DMCA and other copyright information. An equal opportunity/access/affirmative action/pro-disabled and veteran employer.