University of Missouri School of Medicine MU Health School of Medicine
News Divider
            


Tim Domeier, PhD
MU cardiovascular researcher Tim Domeier, PhD, has received a National Institute on Aging Mentored Research Scientist Development Award to support his studies on how calcium affects heart function.


Calcium Research Could Lead to Better Treatments for Aging Hearts


Federal award will expand study of element's influence on individual heart muscle cells

Bone health isn't the only thing that calcium affects as the body ages. A University of Missouri researcher has received a new federal award to examine how calcium also influences aging heart muscle.

Tim Domeier, PhD, assistant professor of medical pharmacology and physiology at the University of Missouri School of Medicine, has received a National Institute on Aging Mentored Research Scientist Development Award to support his studies on how calcium affects heart function. The award provides five years of continuous funding for Domeier to expand his research under the guidance of senior cardiovascular scientists at MU.

"As the heart gets older, we know it loses some of its function. The body responds to this aging process by filling the heart with more blood volume," Domeier said. "Much like a balloon stretches when it's filled with air, heart muscle cells stretch when faced with higher blood volume, and this may cause release of more calcium within cells."

The body uses calcium to send signals to various organ systems. In the heart, calcium tells the organ when to beat, how hard to beat, and how long to beat. But the calcium signal must also turn off, and if not properly regulated can lead to conditions such as heart failure, arrhythmia, and even sudden cardiac death.

Domeier's laboratory seeks to uncover the mechanisms by which calcium levels are altered with disease and translate those findings into treatments for patients. Using an advanced imaging process called confocal laser scanning fluorescence microscopy, he monitors the function of calcium channels, calcium pumps, and calcium transporters in individual heart cells.

Heart Muscle Cells
Diseased heart muscle cells that are unable to properly control their level of calcium when the heart dialates are visualized with confocal fluorescence microscopy in Domeier's lab.


"Calcium may not only tell the heart when to beat but also when to grow and even when to die," Domeier said. "Aging heart muscle has difficulty regulating calcium, which makes elderly individuals more likely to develop heart problems. Our goal is to find out ways to help the aging heart handle calcium and develop therapies to improve the cardiovascular health of our rapidly expanding aging population."

Domeier received his doctorate in cellular and molecular physiology from Yale University and conducted postdoctoral research in cell physiology at Loyola University in Chicago. He served as an instructor in molecular biophysics and physiology at Rush University Medical Center before joining the University of Missouri in 2010.

"This competitive award from the National Institute on Aging is a testament to Dr. Domeier's promising cardiovascular research," said Ronald Korthuis, PhD, George L. and Melna A. Bolm Distinguished Chair in Cardiovascular Health at MU. "Projects like his propel us toward even greater discoveries and improved training for new scientists."

The University of Missouri School of Medicine's Department of Medical Pharmacology and Physiology is ranked among the nation's top such departments in terms of research funding. It's scientists specialize in cardiovascular physiology and pharmacology, exercise physiology, membrane biology and biophysics, radiopharmaceuticals, and receptor and molecular signaling.






News and Events

Staveley-O'Carroll Staveley-O’Carroll Named Surgery Chair, Cancer Center Director
Staveley-O’Carroll is accomplished physician-scientist

Mini Med High School Students get Hands-On Medical School Experience
MU School of Medicine hosts High School Mini Medical School

Cristo Rey MU Health System Partnership Promotes Diversity
Annual summit encourages students to try on health care careers

Hwang Key Component in Protein that Causes Cystic Fibrosis Identified
Findings may lay foundation for the development of medications

SOM Graduation 2015 MU School of Medicine to Award 101 Medical Degrees at Commencement
Forty-five will remain in Missouri for specialty training in residency

George Kracke Potential New Painkiller Provides Longer Lasting Effects
Early studies show promise for alternative type of anesthetic

Durante Enzyme Responsible for Obesity-Related Hypertension Identified
Discovery may lead to new treatment options for arterial disease caused by obesity

Family Medicine AAFP Award MU Family Medicine Ranked Among Nation’s Best by AAFP
Medical school in top 10 for helping build family physician workforce

Legacy Teachers Medical Students Thank Legacy Teachers
MU’s unique program celebrates patients’ role in teaching future physicians

58th Alumni awards Eight Graduates and Supporters Receive 58th Annual Alumni Awards
Syed Arshad Husain presented with top honor

St. Baldricks Participants Go Bald for Childhood Cancer Research
Community donates more than $33,000 to the cause




Media Relations
University of Missouri Health System
One Hospital Drive, DC028.00
Columbia, MO 65212
24/7 on-call pager: (573) 876-0708

Mary Jenkins
jenkinsmg@health.missouri.edu
(573) 882-7299

Jeff Hoelscher
hoelscherj@health.missouri.edu
(573) 884-1608

Derek Thompson
thompsonder@health.missouri.edu
(573) 882-3323

Justin Kelley (Photographer)
kelleyju@health.missouri.edu
(573) 882-5786
Pager (573) 397-9289


Web Communications
University of Missouri Health System
One Hospital Drive, MA204G, DC018.00
Columbia, MO 65212
(573) 884-0298

Rich Gleba
glebar@health.missouri.edu
(573) 884-0298

Laura Gerding, APR
gerdingla@health.missouri.edu
(573) 882-9193

Velvet Hasner
hasnerv@health.missouri.edu
(573) 884-1115



Printer Friendly
Follow us on Twitter!   Facebook   YouTube Videos   Instagram   Pinterest  
Website created and maintained by the Office of Communications. Contact the MU School of Medicine.
Revised: April 27, 2013 - Copyright © 2014 - Curators of the University of Missouri. All rights reserved. DMCA and other copyright information. An equal opportunity/access/affirmative action/pro-disabled and veteran employer.