University of Missouri School of Medicine MU Health School of Medicine
News Divider
Join us on Facebook!   Follow us on Twitter!   Subscribe to us!      



Binge Drinking
Described in the current issue of Alcoholism: Clinical & Experimental Research, a study at the University of Missouri has revealed a unique connection between binge drinking and the risk for developing alcoholic liver disease and a variety of other health problems.



New Research Shows Weekend Binge Drinking Could Leave Lasting Liver Damage


Overconsumption of alcohol creates a different kind of liver damage that affects key organ functions

Long after a hangover, a night of bad decisions might take a bigger toll on the body than previously understood. Described in the current issue of Alcoholism: Clinical & Experimental Research, a study at the University of Missouri has revealed a unique connection between binge drinking and the risk for developing alcoholic liver disease and a variety of other health problems.

Shivendra Shukla, PhD
Shukla

"In our research, we found that binge drinking has a profound effect on the liver in various modes of alcohol exposure," said Shivendra Shukla, PhD, Margaret Proctor Mulligan Professor at the University of Missouri School of Medicine and corresponding author of the study. "No longer can we consider chronic alcohol consumption as the only factor in developing alcoholic liver disease."

Shukla said it's important to note there will be more liver injury in a chronic alcoholic if that person binge drinks, but a binge drinker may sensitize the liver over a longer period and make it prone to more damage. MU researchers studied the effects of binge drinking when coupled with chronic alcohol consumption and also in isolated cases of binge drinking not associated with chronic alcohol consumption.

Nationwide and in Missouri, binge drinking is on the rise. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines binge drinking for women as having four or more drinks in two hours; for men, it is five or more drinks in two hours. An estimated 29 percent of women and 43 percent of men have reported experiencing at least one binge drinking episode over the course of a year.

Through their study of alcohol exposure in rats, researchers in Shukla's lab found binge drinking amplifies injury to the liver when there was pre-exposure due to chronic alcohol consumption. As the main metabolic site for the body, the liver affects many systems in the body, including nutrient and drug metabolism and distribution, as well as the production of multiple agents that are needed for the heart, kidney, blood vessels and brain to function properly.

"Binge drinking should not be associated with only liver damage," said Shukla, a professor of medical pharmacology and physiology. "It creates an inflammatory response in the liver that is like a cluster bomb, sending out various damaging signals to systems in the body. If those organs are working at a lower level of function, then a whole host of physiological processes is affected."

Research in Shukla's laboratory is funded by the National Institute on Alcohol Abuse & Alcoholism (NIAAA).


Click here to download a high-resolution portrait of Shukla.







MU Health Magazine

Divider

News and Events

Evans Evans Named Associate Dean and Chief Academic Officer for Springfield Clinical Campus
Role is to engage Columbia and Springfield leaders to provide strategic direction and vision
Robin Kruse, PhD Lack of Research Keeps End-of-Life Care in Status Quo
MU researcher finds only 10 clinical trials conducted in hospices since 1985, says more studies could improve patient care

Govindarajan MU Neurologist Earns National Education Honor
Raghav Govindarajan, MD, to receive National Golden Apple Award for Teaching Excellence

David Beversdorf Blood Pressure Medicine May Improve Conversational Skills of Individuals with Autism
Propranolol found to boost performance on six key components of communication

HMI Health Management and Informatics Professor Leads Largest Health Survey in Missouri
MU research center receives $2.13 million grant to survey more than 52,000 Missourians
Kattesh Katti, PhD MU Radiology Professor Named India’s Person of the Year in Science
Katti honored for breakthrough research in nanomedicine and green nanotechnology
Frederick Fraunfelder, MD Chickenpox, Shingles Vaccine May Cause Corneal Inflammation in Some Patients
Primary care physicians should be aware of possible vision side effect for susceptible patients
Infant-friendly Flu Vaccine Infant-friendly Flu Vaccine Developed with Key Protein
Natural additive offers protection against flu for babies younger than six months
Rural Area Medical School Program Addresses Rural Physician Shortage
Service learning enhances medical training, may increase rural practitioners




Media Relations
University of Missouri Health System
One Hospital Drive, DC028.00
Columbia, MO 65212
24/7 on-call pager: (573) 876-0708

Mary Jenkins
jenkinsmg@health.missouri.edu
(573) 882-7299

Jeff Hoelscher
hoelscherj@health.missouri.edu
(573) 884-1608

Derek Thompson
thompsonder@health.missouri.edu
(573) 882-3323

Diamond Dixon
DixonDi@health.missouri.edu
(573) 884-7541

Justin Kelley (Photographer)
kelleyju@health.missouri.edu
(573) 882-5786
Pager (573) 397-9289


Web Communications
University of Missouri Health System
One Hospital Drive, MA204G, DC018.00
Columbia, MO 65212
(573) 884-0298

Jennifer Orford
orfordj@health.missouri.edu
(573) 882-0298

Jesslyn Chew
chewj@missouri.edu
(573) 884-2891

Velvet Hasner
hasnerv@health.missouri.edu
(573) 884-1115

Justin Willett
willettj@health.missouri.edu
(573) 884-7740



Printer Friendly
Follow us on Twitter!   Facebook   YouTube Videos   Instagram   Pinterest  
Website created and maintained by the Office of Communications. Contact the MU School of Medicine.
Revised: December 01, 2015 - Copyright © 2014 - Curators of the University of Missouri. All rights reserved. DMCA and other copyright information. An equal opportunity/access/affirmative action/pro-disabled and veteran employer.