University of Missouri School of Medicine MU Health School of Medicine
News Divider
George Kracke, PhD
Researchers led by George Kracke, PhD, have discovered a new compound that offers longer lasting painkilling effects, and shows promise as an alternative to current anesthetics. The new compound developed at MU, boronicaine, could potentially serve many of those same functions as an injectable or topical painkiller. Kracke is associate professor of anesthesiology and perioperative medicine at the MU School of Medicine.


Potential New Painkiller Provides Longer Lasting Effects


Early studies show promise for alternative type of anesthetic

Medications have long been used to treat pain caused by injury or chronic conditions. Unfortunately, most are short-term fixes or cause side effects that limit their use. Researchers at the University of Missouri have discovered a new compound that offers longer lasting painkilling effects, and shows promise as an alternative to current anesthetics.

“Because of its versatility and effectiveness at quickly numbing pain in targeted areas, lidocaine has been the gold standard in local anesthetics for more than 50 years,” said George Kracke, PhD, associate professor of anesthesiology and perioperative medicine at the MU School of Medicine and lead author of the study. “While lidocaine is effective as a short-term painkiller, its effects wear off quickly. We developed a new compound that can quickly provide longer lasting relief. This type of painkiller could be beneficial in treating sports injuries or in joint replacement procedures.”

Painkillers work by interfering with the nervous system’s transmission of nerve signals that the body perceives as pain. Lidocaine is used as an injectable pain reliever in minor surgical or dental procedures, or as a topical ointment or spray to relieve itching, burning and pain from shingles, sunburns, jellyfish stings and insect bites. The new compound developed at MU, boronicaine, could potentially serve many of those same functions as an injectable or topical painkiller.

National Academy of Sciences member M. Frederick Hawthorne, PhD, director of MU’s International Institute of Nano and Molecular Medicine and a pioneer in the field of boron chemistry, synthesized boronicaine as a derivative of lidocaine. By changing aspects of the chemical structure of lidocaine, the researchers found that the new compound provided pain relief that lasted five times longer than lidocaine. In pre-clinical, early stage studies, boronicaine provided about 25 minutes of relief, compared to about five minutes of pain relief with lidocaine.

“Although some conditions may warrant the use of a short-lasting painkiller, in many cases a longer lasting anesthetic is a better option,” Kracke said. “Having a longer lasting anesthetic reduces the dosage or number of doses needed, limiting the potential for adverse side effects.”

While other types of painkillers can provide longer pain relief than lidocaine, they can cause heart toxicity, gastrointestinal issues and other side effects. Preliminary findings show no toxicity in single-dose studies of boronicaine, though more studies are needed.

“Boronicaine could have distinct advantages over existing painkilling medications,” said Hawthorne, who also serves as the Curators’ Distinguished Professor of Chemistry and Radiology at MU. “We’re conducting more research into the side effects of the compound, but in time it could very well become a useful material to use as an anesthetic.”

The study, “Carborane-derived Local Anesthetics Show Isomer-dependent Analgesia,” was presented on March 29 at the Experimental Biology 2015 conference in Boston, and the research was recently published in the medicinal chemistry journal ChemMedChem. The research is funded by the University of Missouri System Intellectual Property Fast Track Funding Program, the MU International Institute of Nano and Molecular Medicine, and the MU Department of Anesthesiology and Perioperative Medicine.

Click here to download a high-resolution photo of George Kracke, PhD.

Posted May 7, 2015



MU Health Magazine

Divider

News and Events

David Chang Grill with Caution
Wire bristles from barbecue brushes can cause serious injuries
Tahir Rahman Extreme Beliefs Often Mistaken for Insanity, New Study Finds
Researchers say new term offers more precise definition of non-psychotic behaviors
Paul Tatum Family Medicine Professor Wins Distinguished Physician Award
Tatum recognized for outstanding care of patients near the end of life
Seth Sherman Minimally Invasive Tendon Repair Technique Supports Knee Movement Sooner after Surgery
Researchers found suture anchors, a less-invasive repair technique, responded better to strength-testing after surgery
2016 Graduation MU School of Medicine Awards 86 Medical Degrees at Commencement Ceremony
The graduates will go on to receive additional training as resident physicians in their chosen specialties
Patrice Delafontaine MU School of Medicine Dean Inducted into Prestigious Medical Society
Delafontaine joins elite group of physicians in American Clinical and Climatological Association
Steven Zweig MU Family Medicine Ranked Among Nation’s Best by U.S. News & World Report
Department has been in top 10 for 23 consecutive years
Uzma Khan MU Initiative Helps Rural Doctors Treat Chronic Pain
Show-Me ECHO to offer special training session April 28
Legacy Teachers MU School of Medicine Program Expands to Other Medical Schools
MU’s Legacy Teachers program lets students recognize patients as educators
Susan Nagel Oil and Gas Wastewater Disposal May Increase Endocrine Disrupting Activity
Scientists draw conclusions after study at natural gas and oil extraction wastewater disposal facility
St. Baldricks 2016 Participants Go Bald for Childhood Cancer Research
Community donates more than $40,000 to the cause



Media Relations
University of Missouri Health System
One Hospital Drive, DC028.00
Columbia, MO 65212
24/7 on-call pager: (573) 876-0708

Mary Jenkins
jenkinsmg@health.missouri.edu
(573) 882-7299

Jeff Hoelscher
hoelscherj@health.missouri.edu
(573) 884-1608

Derek Thompson
thompsonder@health.missouri.edu
(573) 882-3323

Diamond Dixon
DixonDi@health.missouri.edu
(573) 884-7541

Justin Kelley (Photographer)
kelleyju@health.missouri.edu
(573) 882-5786
Pager (573) 397-9289


Web Communications
University of Missouri Health System
One Hospital Drive, MA204G, DC018.00
Columbia, MO 65212
(573) 884-0298

Jennifer Orford
orfordj@health.missouri.edu
(573) 882-0298

Jesslyn Chew
chewj@missouri.edu
(573) 884-2891

Velvet Hasner
hasnerv@health.missouri.edu
(573) 884-1115

Justin Willett
willettj@health.missouri.edu
(573) 884-7740



Printer Friendly
Follow us on Twitter!   Facebook   YouTube Videos   Instagram   Pinterest  
Website created and maintained by the Office of Communications. Contact the MU School of Medicine.
Revised: May 07, 2015 - Copyright © 2014 - Curators of the University of Missouri. All rights reserved. DMCA and other copyright information. An equal opportunity/access/affirmative action/pro-disabled and veteran employer.