School of Medicine
William Fay, MD, J.W. and Lois Winifred Stafford Distinguished Chair in Diabetes and Cardiovascular Research, has been awarded an $815,625 grant from the Missouri Life Sciences Research Board for his study of cardiac catheterization.

State Awards Research Grant to Reduce Complications of Cardiac Treatment

Fay's research team works to prevent artery re-narrowing, enable artery repair

Missouri ranks eighth in the nation in residents' incidence of cardiovascular disease, and recently the state dedicated significant funding to research aimed at preventing the most serious complications accompanying treatment.

In 2008, the Missouri Life Sciences Research Board awarded $13.1 million in research and commercialization grants to 14 research projects. William Fay, MD, J.W. and Lois Winifred Stafford Distinguished Chair in Diabetes and Cardiovascular Research, leads one of six MU teams to receive funding from the state's research trust fund, in the amount of $815,625.

Fay, a professor of internal medicine, pharmacology and medical physiology and director of cardiovascular medicine, said the state's investment enables collaborating researchers at the School of Medicine and College of Veterinary Medicine to take their hypothesis to the next level by testing it in a pig model, whose cardiac anatomy is very similar to a human's. He will closely collaborate with Douglas Bowles, PhD, associate professor of biomedical sciences at the veterinary school, to use the resources available at MU's National Swine Resource and Research Center.

"Developing new strategies to treat coronary disease will be beneficial to the citizens of Missouri," Fay said. "I think that our multidisciplinary team is very well-positioned to have some spinoff element that will have financial implications with obviously the long-term goal of providing patients with better treatment."

During cardiac catheterization, a flexible tube, or catheter, is threaded through an artery. If a blockage is detected, doctors clear it and place a drug eluting stent – a tubular wire mesh scaffold coated with drugs to improve blood flow and prevent re-narrowing of the artery. Unfortunately, in recent years, researchers have noted an unwanted side effect of the drug coating.

"Drug eluting stents are very good, but it's hard to develop a perfect treatment and one of their limitations is there can be a problem with clotting later on," Fay said. "They inhibit the artery-clogging smooth muscle cells from growing in, but they also inhibit the normal repair of cells in the artery lining."

Fay's team will focus on new strategies to prevent the re-narrowing of the arteries while ensuring normal, healthy cell repair in the artery lining. In particular, his multidisciplinary team will test a mutant protein compound that preliminary studies show could delay plaque re-formation without promoting clotting.

The Life Sciences Research Board weighted funding proposals based on their scientific merits and their abilities to use funding to provide statewide economic return, as well as their alignment with state priorities.

"This has been a highly-competitive process," said Roger Mitchell, PhD, the board's chair. "These newly-awarded grants will leverage substantial additional investment in Missouri."

Students Reach Out to Uninsured
Mid-Missouri's first student-operated
outreach clinic provides free care,
prescriptions and lab tests to patients
Screens Losing Weight With No Incisions
Surgeons use experimental TOGA
treatment to deliver less pain, shorter
hospital stay and quicker recovery
New Pediatric and Psychiatry Leaders
Timothy Fete is consolidating MU
Children's Hospital, and John Lauriello
will arrive to improve mental health
Unprecedented Gift Forms 12 Positions
Mrs. Mulligan enhances effort to treat
or prevent the most prevalent
diseases — cardiovascular disease and cancer
Eight to Receive 52nd Alumni Awards
Leslie Miller, MD '74, Georgetown
University cardiology chief, to be
presented with top honor April 2
Microcirculation Research has MERIT
Steven Segal awarded for defining
signaling processes that control blood
flow in the smallest vessels
Stopping Cardiac Care Side Effects
Grant helps William Fay find new
strategies for preventing re-narrowing
of arteries after catheterization
Investing in Informatics
Mark McIntosh's core facility will take
on the terabytes of data generated by
experiments in life sciences
Decoding the Language of Memory Cells
In the journal Science, Emma Teixeiro
details a communication breakdown
impacting vaccination, cancer research
Biocontainment Lab One of 13 in U.S.
Building constructed with $13.4 million
NIH grant helps attract top infectious
disease scientists and defend against
public health threats
Priestley Medal for Pioneering Chemist
World's largest scientific society will
present its highest honor to Fred
Hawthorne, Institute of Nano and
Molecular Medicine director
Skull Expert Elected AAAS Fellow
Matthew Ravosa recognized for work
in paleontology, experimental biology
and mammalian evolution
Exercise Prevents Liver Disease
Jamal Ibdah discovers that fatty liver
disease, common among obese
people, is preventable and reversible
Unlocking Microscopic Mysteries
Using atomic force microscopy, Gerald
Meininger peers at proteins that hold
clues to blood vessel function
Detecting Diabetes Before Diagnosis
A new clinical tool helps Richelle
Koopman keep younger patients from
progressing to morbidity and mortality
Herbal Immune Booster
Medical student Kelsey Flynt
investigates interactions of traditional
African treatment and HIV drugs
Heart Wired
Studying electrical activity in
developing chicken hearts could help
Luis Polo-Parada improve therapies
for cardiac conditions
Now Showing: ICTS
Institute for Clinical and Translational Science is transforming research by uniting scientists across campus for bench-to-bedside studies

Follow us on Twitter!   Facebook   YouTube Videos   Instagram   Pinterest  
Website created and maintained by the Office of Communications.  Contact the MU School of Medicine.
Revised: May 21, 2013 - Copyright © 2015 - Curators of the University of Missouri. All rights reserved. DMCA and other copyright information. An equal opportunity/access/affirmative action/pro-disabled and veteran employer.