University of Missouri School of Medicine MU Health School of Medicine

Danny Schust, MD

Danny Schust, MD

Associate Professor of Clinical Obstetrics and Gynecology
Division Director, Reproductive Endocrinology & Infertility


Medical School 

  • University of WI School of Medicine, Madison


  • Obstetrics & Gynecology, University of North Carolina, Chapel Hill


  • Brigham & Women's Hospital, Harvard Medical School, Boston

Board Certification 

  • Reproductive Endocrinology & Infertility, Obstetrics & Gynecology, 1998


  • Member, The American Association of Clinical Endocrinologists
  • Member, The American Institute for Ultrasound in Medicine
  • Member, The Society for Gynecologic Investigation
  • Member, The American Society for Reproductive Medicine (ASRM)
  • Member, The Society for the Study of Reproduction
  • Member, The National Physicians Cooperative for the Preservation of Fertility in Females with Cancer
  • President, Reproductive Immunology Special Interest Group, ASRM


Clinical and Research Interests
  • Recurrent Pregnancy Loss
  • AIDS/HIV Infection
  • Allergy/Immunology
  • Artificial Insemination
  • Contraception/Family Planning
  • Gynecologic Endocrinology
  • Hysteroscopy
  • In Vitro Fertilization
  • Infertility
  • Laparoscopy and Laser Surgery
  • Sexually Transmitted Diseases
Personal Interests
  • International Travel
  • Theater


Currently none available.




William T. Griffin, MD and Roberta Ann Griffin Distinguished Faculty Scholar in Obstetrics and Gynecology



Resident Mentoring Award, Department of Obstetrics and Gynecology, Boston Unv. School of Medicine, Boston, MA



SGI President’s Presenter Award, The Society for Gynecologic Investigation Annual Meeting, Toronto, Canada



SGI President’s Presenter Award, The Society for Gynecologic Investigation Annual Meeting, Los Angeles, CA



Reproductive Immunology Special Interest Group Prize paper, The American Society of Reproductive Medicine Annual Meeting, Philadelphia, PA



Humanism in Medicine Mentoring Award, Harvard Medical School



Teaching Award in Reproductive Endocrinology, Brigham and Women’s Hospital, Harvard Medical School



Women’s Reproductive Health Research Training Grant



Resident Teaching Award in Gynecology, Brigham and Women’s Hospital, Harvard Medical School



Reproductive Scientist Development Award


  • Nagamatsu T, Schust DJ. The immunomodulatory roles of macrophages at the maternal-fetal interface. Reproductive Sciences. 17(3):209-18, 2010. PMID: 20065301
  • Nagamatsu T. Schust DJ. Sugimoto J. Barrier BF. Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions. Human Reproduction. 24(12):3160-71, 2009. PMID: 19729380
  • Allison JL. Schust DJ. Recurrent first trimester pregnancy loss: revised definitions and novel causes. Current Opinion in Endocrinology, Diabetes & Obesity. 16(6):446-50, 2009. PMID: 19779333
  • Sugimoto J, Schust DJ. Review: human endogenous retroviruses and the placenta. Reproductive Sciences 16(11):1023-33, 2009. PMID: 19474286
  • Kawana K. Matsumoto J. Miura S. Shen L. Kawana Y. Nagamatsu T. Yasugi T. Fujii T. Yang H. Quayle AJ. Taketani Y. Schust DJ. Expression of CD1d and ligand-induced cytokine production are tissue specific in mucosal epithelia of the human lower reproductive tract. Infection & Immunity. 76(7):3011-8, 2008. PMID: 18458073
  • Retzloff MG, Combelles CMH, Bowman FP, Racowsky C, Schust DJ. Interleukin-10 levels in single human embryo conditioned media help predict implantation [in review] * Ramhorst RE, Patel R, Corigliano A, Etchepareborda JJ, Fainboim L, Schust DJ. Induction of maternal tolerance to fetal alloantigens involves RANTES production [in review]
  • Tomio A. Schust DJ. Kawana K. Yasugi T. Kawana Y. Mahalingaiah S. Fujii T. Taketani Y. Prolactin can modulate CD4+ T-cell response through receptor-mediated alterations in the expression of T-bet. Immunology & Cell Biology , 2009, 86(7):616-621. PMID: 18414429
  • Kawana K. Quayle AJ. Ficarra M. Ibana JA. Shen L. Kawana Y. Yang H. Marrero L. Yavagal S. Greene SJ. Zhang YX. Pyles RB. Blumberg RS. Schust DJ. CD1d degradation in Chlamydia trachomatis-infected epithelial cells is the result of both cellular and chlamydial proteasomal activity. Journal of Biological Chemistry. 282(10):7368-75, 2007. PMID: 17215251
  • Anderson BJ. Haimovici F. Ginsburg ES. Schust DJ. Wayne PM. In vitro fertilization and acupuncture: clinical efficacy and mechanistic basis. Alternative Therapies in Health & Medicine. 13(3):38-48, 2007. PMID: 17515023
  • Matsumoto J. Kawana K. Nagamatsu T. Schust DJ. Fujii T. Sato H. Hyodo H. Yasugi T. Kozuma S. Taketani Y. Expression of surface CD1d in the extravillous trophoblast cells of early gestational placenta is downregulated in a manner dependent on trophoblast differentiation. Biochemical & Biophysical Research Communications. 371(2):236-41, 2008. PMID: 18433720
  • Lightner A. Schust DJ. Chen YB. Barrier BF. The fetal allograft revisited: does the study of an ancient invertebrate species shed light on the role of natural killer cells at the maternal-fetal interface? Clinical & Developmental Immunology. 2008:631920, 2008. PMID: 18615195
  • Ginsburg ES, Xiao L, Gargiulo AR, Kung F-T, Politch JA, Schust DJ, Hill JA. T-helper 2 and 3-type immunity to trophoblast in successful IVF-ET. Fertility and Sterility, 2005; 83(6): 1659-64. PMID: 15950633
  • Kawana K, Kawana Y, Schust DJ. Female steroid hormones utilize Stat protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. Molecular Endocrinology 2005; 19(8): 2047-2059. PMID: 15860546
  • Castle PE, Rodriguez A-C, Bowman FP, Herrero R, Schiffman M, Schust DJ, Crowley-Nowick P, Hildescheim A. A comparison of ophthalmic sponges for measurement of immune markers from cervical secretions. Clinical and Diagnostic Laboratory Immunology, 2004;11(2):399-405.
  • Huddleston H. Schust DJ. Immune interactions at the maternal-fetal interface: a focus on antigen presentation. American Journal of Reproductive Immunology. 51(4):283-9, 2004. PMID: 15212681
  • Yao MW, Lim H, Schust DJ, Choe SE, Farago A, Ding Y, Michaud S, Church GM, Maas RL. Gene expression profiling reveals progesterone-mediated cell cycle immunoregulatory roles of Hoxa-10 in the preimplantation uterus. Molecular Endocrinology. 2003; 17(4):610-27. PMID: 12554760
  • Patel R, Hill JA, Schust DJ. Embryonic chromosomal status does not alter the expression of HLA-G at the maternal-fetal interface in patients with a history of recurrent spontaneous pregnancy loss. Molecular Human Reproduction. 2003;9(9):551-7. PMID: 12900514
  • Norwitz ER. Schust DJ. Fisher SJ. Implantation and the survival of early pregnancy. New England Journal of Medicine. 345(19):1400-8, 2001. PMID: 11794174
  • Gould DS, Ploegh H, Schust DJ. Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells. Journal of Reproductive Immunology. 2001;52:85-89. PMID: 11600180
  • Gewurz BE, Wang EW, Tortorella D, Schust DJ, Ploegh HL. The ER-lumenal domain of Cytomegalovirus (HCMV) gene product US2 dictates association with Major Histocompatibility Complex (MHC) class I in a locus-specific manner. Journal of Virology. 2001;75(11):5197-604. PMID: 11333901
  • Furman MH, Ploegh HL, Schust DJ. Re-classification of MHC class I products: Can viruses help us to understand the relevance of class I molecules at the maternal-fetal interface? Human Immunology. 2000; 61(11):1169-1176. PMID: 11137223
  • Das G, Gould DS, Augustine MW, Fragoso G, Scitto E, Stroynowski I, Van Kaer L, Schust DJ, Janeway CA, Jr. Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes. Journal of Experimental Medicine 2000; 192(10):1521-1527. PMID: 11085754
  • Paul P, Rouas-Freiss N, Moreau P, Cabestre FA, Menier C, Khalil-Daher I, Pangault C, Onno M, Fauchet R, Martinez-Laso J, Morales P, Villena AA, Giacomini P, Natali PG, Frumento G, Ferrara GB, McMaster M, Fisher S, Schust D, Ferrone S, Dausset J, Geraghty D, Carosella ED. HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression. Human Immunology 2000;61(11):1177-1195.
  • Tortorella, D. Gewurz, B E. Furman, M H. Schust, D J. Ploegh, H L. Viral subversion of the immune system. Annual Review of Immunology. 18:861-926, 2000. PMID: 10837078
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