Profile
Dr. Stoker's research focuses on understanding disease pathogenesis and pathobiology; the identification of validation of biomarkers for early diagnosis, staging, treatment monitoring and prognostication; and developing and optimizing treatment strategies for osteoarthritis and other orthopaedic maladies. His research efforts have focused on the development, characterization and validation of numerous in vitro, ex vivo and in vivo models of osteoarthritis and other joint disease. He developed numerous models designed to expand the study of pathology associated with primary osteoarthritis, post-traumatic osteoarthritis, ACL tears and degeneration, meniscal deficiency, intervertebral disc disease, rotator cuff pathology and articular cartilage defects.
These models provide vital information regarding the response of joint tissue to various stimuli and the role of these tissues in the development and rogression of orthopaedic disorders. Further, these models have consistently proven effective for the evaluation of the safety and efficacy of novel treatment strategies for these disorders. The basic science, translational and clinical research teams at the TLRO are making major progress in developing and validating improved treatment options for osteoarthritis using these models. He and the rest of the team have guided numerous therapies through the process of regulatory approval, clinical trials and post‐market studies. Their approach to placing science behind the surgery promotes safe and effective options for patients.
Academic Information
Office
1100 Virginia Avenue
Columbia, MO 65212
United States
Areas of Expertise
- Biomarkers of osteoarthritis
- Development and use of in vitro models for the study of tissue normal and pathologic tissue metabolism
- Development and use of in vitro models for screening of potential treatments
- cartilage biology
- Intervertebral disc biology
- Meniscal biology
- Ligament biology
- Infrapatellar fat pad biology
Related Links
Education & Training
Post-Graduate School
University of Missouri, 2004
Awards & Honors
- 2018 University of Missouri’s Outstanding Undergraduate Research Mentor of the Year
- 2006-present Orthopaedic Research Society
- 2005 Comparative Orthopaedic Laboratory Excellence in Research Award
- 2004-present Osteoarthritis Research Society International
- 2004-2005 Robert B. Gordon Arthritis Research Fellowship
- 2004 Phi Zeta Research Day. 2nd Place Post-Doctoral and Advanced Graduate Students, University of Missouri, Columbia
Publications
- Stoker AM, Caldwell KM, Stannard JP, Cook JL. Metabolic responses of osteochondral allografts to re-warming. J Orthop Res 2019. PMID: 30912859.
- Cook AE, Stoker AM, Leary EV, Pfeiffer FM, Cook JL. Metabolic responses of meniscal explants to injury and inflammation ex vivo. J Orthop Res 2018;36(10):2657-2663. PMID: 29745431
- Stoker AM, Stannard JP, Cook JL. Chondrocyte viability at time of transplantation for osteochondral allografts preserved by the Missouri Osteochondral Preservation System versus standard tissue bank protocol. J Knee Surg 2018;31(8):7872-780. PMID: 29228404.
- Stoker AM, Stannard JP, Kuroki K, Bozynski CC, Pfeiffer FM, Cook JL. Validation of the Missouri Osteochondral Allograft Preservation System for the maintenance of osteochondral allograft quality during prolonged storage. Am J Sports Med 2018;46(1):58-65. PMID: 28937783
- Stoker AM, Baumann CA, Stannard JP, Cook JL. Bone marrow concentrate versus platelet rich plasma to enhance osseous integration potential for osteochondral allografts. J Knee Surg 2018;31(4):314-320. PMID: 28646824.
- Kuroki K, Stoker AM, Stannard JP, Bozynski CC, Cook CR, Pfeiffer FM, Cook JL. Biologic joint repair strategies: The Mizzou BioJoint story. Toxicol Pathol 2017;45(7):931-938. PMID: 29020891.
- Cook JL, Stannard JP, Stoker AM, Bozynski CC, Kuroki K, Cook CR, Pfeiffer FM. Importance of donor chondrocyte viability for osteochondral allografts. Am J Sports Med 2016;44(5):1260-1268. PMID: 26920431.
- Brimmo OA, Pfeiffer FM, Bozynski CC, Kuroki K, Cook CR, Stoker AM, Sherman SL, Monibi FA, Cook JL. Development of a novel canine model for posttraumatic osteoarthritis of the knee. J Knee Surg 2016;29(3):235-241. PMID: 25892003.
- Cook JL, Stoker AM, Stannard JP, Kuroki K, Cook CR, Pfeiffer FM, Bozynski CC, Hung CT. A novel system improves preservation of osteochondral allografts. Clin Orthop Relat Res 2014;472:3404-3414. PMCID: PMC4182376
- Stoker AM, Garrity JT, Hung CT, Stannard JP, Cook J. Improved preservation of fresh osteochondral allografts for clinical use. J Knee Surg 2012;25(2):117-125. PMID: 22928429.