Aaron Stoker, PhD

Orthopaedic Surgery

Associate Research Professor
Associate Director of the Thompson Laboratory for Regenerative Orthopaedics

573-882-4154

Academic Information

Associate Research Professor
Associate Director of the Thompson Laboratory for Regenerative Orthopaedics

Office

1100 Virginia Avenue
Columbia, MO 65212
United States

P. 573-882-4154

Research Interests

Osteoarthritis is the nation’s leading cause for disability, affecting more than 25 million Americans. Dr. Stoker’s research focuses on understanding disease pathogenesis and pathobiology; the identification of validation of biomarkers for early diagnosis, staging, treatment monitoring and prognostication; and developing and optimizing treatment strategies for osteoarthritis and other orthopaedic maladies. His research efforts have focused on the development, characterization and validation of numerous in vitroex vivo and in vivo models of osteoarthritis and other joint disease. He has developed numerous models designed to expand study the pathology associated with primary osteoarthritis, post-traumatic osteoarthritis, ACL tears and degeneration, meniscal deficiency, intervertebral disc disease, rotator cuff pathology and articular cartilage defects. These models provide vital information regarding the response of joint tissue to various stimuli and the role of these tissues in the development and progression of orthopaedic disorders. Further, these models have consistently proven effective for the evaluation of the safety and efficacy of novel treatment strategies for these disorders. The basic science, translational and clinical research teams at the TLRO are making major progress in developing and validating improved treatment options for osteoarthritis using these models.  We have guided numerous therapies through the process of regulatory approval, clinical trials and post-market studies. Our approach to placing science behind the surgery promotes safe and effective options for patients.

Areas of Expertise

  • Biomarkers of orthopaedic disease
  • In vitro, ex vivo and in vivo modeling of orthopaedic tissue health and disease
  • Osteochondral allograft preservation

Related Links

Education & Training

Post-Graduate School

University of Missouri, 2004

Awards & Honors

  • Osteoarthritis Research Society International, 2004-present
  • Orthopaedic Research Society, 2006-present

Publications

  • Cook JL, Stoker AM, Stannard JP, Kuroki K, Cook CR, Pfeiffer FM, Bozynski CC, & Hung CT (2014). A novel system improves preservation of osteochondral allografts. Clin Orthop Relat Res, 472:3404-3414. PMCID: PMC4182376
  • Cook JL, Stannard JP, Stoker AM, Bozynski CC, Kuroki K, Cook CR, & Pfeiffer FM (2016). Importance of Donor Chondrocyte Viability for Osteochondral Allografts. Am J Sports Med, 44(5):1260-1268. PMID: 26920431
  • Garner BC, Kuroki K, Stoker AM, Cook CR, & Cook JL (2013). Expression of proteins in serum, synovial fluid, synovial membrane, and articular cartilage samples obtained from dogs with stifle joint osteoarthritis secondary to cranial cruciate ligament disease and dogs without stifle joint arthritis. Am J Vet Res, 74(3):386-94. PMID: 23438113
  • Cook JL, Cook CR, Stannard JP, Vaughn G, Wilson N, Roller BL, Stoker AM, Jayabalan P, Hdeib M, & Kuroki K (2014). MRI versus Ultrasonography to Assess Meniscal Abnormalities in Acute Knees. J Knee Surg, 27(4):319-24. PMID: 24474166
  • Roller BL, Monibi FAA, Stoker AM, Kuroki K, B Bal S, & Cook JL (2015). Characterization of Knee Meniscal Pathology: Correlation of Gross, Histologic, Biochemical, Molecular, and Radiographic Measures of Disease. J Knee Surg, 28(2):175-82. PMID: 24807193
  • Monibi FA, Roller BL, Stoker AM, Garner B, Bal BS, & Cook JL (2016). Identification of synovial fluid biomarkers for knee osteoarthritis and correlation with radiographic assessment. J Knee Surg 2016, 29(3):242-7. PMID: 25338297
  • Stoker AM, Cook JL, Kuroki K, & Fox DB (2006).  Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs J of Ortho Surg Res, 1(8). PMCID: PMC1636033
  • Garner BC, Stoker AM, Kuroki K, Evans R, Cook CR & Cook JL (2011). Using animal models in osteoarthritis biomarker research. J Knee Surg, 24:251-264. PMID: 22303754
  • Cook JL, Hung CT, Kuroki K, Stoker AM, Cook CR, Pfeiffer FM, Sherman SL, & Stannard JP (2014). Animal models of cartilage repair. Bone Joint Res, 4:89-94. PMCID:PMC3974069
  • Brimmo OA, Pfeiffer FM, Bozynski CC, Kuroki K, Cook CR, Stoker AM, Sherman SL, Monibi FA, & Cook JL (2016). Development of a Novel Canine Model for Posttraumatic Osteoarthritis of the Knee. J Knee Surg, 29:235-241. PMID: 25892003
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