We have previously shown that T and B cells are not required for either resistance or susceptibility to arthritis development. Thus, polymorphisms in the innate immune response control disease development. We have recently shown that the in vivo depletion of neutrophils results in the development of arthritis in resistant mouse strains, and an earlier development of arthritis in susceptible strains. The mechanism of how neutrophils provide protection against disease development in this model is currently under investigation. Our hypothesis is that, as the first cells to arrive at the site of infection, neutrophils are in a perfect position to provide regulatory cytokines and chemokines to guide the developing immune response. To investigate this we are using microarray technology, real-time (Taqman) PCR, ELISA’s, and immunohistochemistry.
315 Connaway Hall
Columbia, MO 65212
- Host response to infectious disease
Areas of Expertise
- Cellular Immunology
- Autoimmunity and Tolerance
- Bacterial Pathogenesis
- Gene Expression
- Immune Response to Pathogens
- Innate Immunity
Education & Training
1993, PhD, University of Chicago
- Brown, C.R., and E.A. Dennis. 2017. Infection with Borrelia burgdorferi induces lipid mediator production during Lyme arthritis. Biochimie 141:86-90.
- Lacey, C.A., W.J. Mitchell, C.R. Brown, and J.A. Skyberg. 2017. Temporal role for MyD88 in joint inflammation in a novel model of Brucella-induced musculoskeletal inflammation and arthritis. Infect. Immun. 85:e00961-16. PMCID: PMC5328475
- Zhang, Y., R.M. Olson and C.R. Brown. 2017. Macrophage LTB4 drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2. J. Lipid Res. 58:494-503. PMCID: PMC5335579
- Lasky, C.E., C.L. Pratt, K.A. Hilliard, J.L. Jones, and C.R. Brown. 2016. T cells exacerbate Lyme borreliosis in TLR2-deficient mice. Front. Immunol. 7:1-12. Article 468. PMCID: PMC5093308
- Lacey, C.A., L.L. Keleher, W.J. Mitchell, C.R. Brown, and J.A. Skyberg. 2016. CXCR2 mediates Brucella-induced arthritis in IFN-g-deficient mice. J. Infect. Dis. 214:151-160. PMCID: PMC4907412
- Lasky, C.E., K.E. Jamison, D.R. Sidelinger, C.L. Pratt, G. Zhang, and C.R. Brown. 2015. Infection of C3H IL-17RA-deficient mice with Borrelia burgdorferi does not affect their development of Lyme arthritis or carditis. Infect. Immun. 83:2882-2888.
- Lasky, C.E., R.M. Olson, and C.R. Brown. 2015. Macrophage polarization during murine Lyme borreliosis. Infect. Immun. In Press.
- Pratt, C.L., and C.R. Brown. 2014. The role of eicosanoids in experimental Lyme arthritis. Front. Cell. Infect. Microbiol. 4:1-6. PMCID: PMC4036060