Charles R. Brown, PhD


We have previously shown that T and B cells are not required for either resistance or susceptibility to arthritis development. Thus, polymorphisms in the innate immune response control disease development. We have recently shown that the in vivo depletion of neutrophils results in the development of arthritis in resistant mouse strains, and an earlier development of arthritis in susceptible strains. The mechanism of how neutrophils provide protection against disease development in this model is currently under investigation. Our hypothesis is that, as the first cells to arrive at the site of infection, neutrophils are in a perfect position to provide regulatory cytokines and chemokines to guide the developing immune response. To investigate this we are using microarray technology, real-time (Taqman) PCR, ELISA’s, and immunohistochemistry.

Academic Information

Veterinary Pathobiology


315 Connaway Hall
Columbia, MO 65212
United States

P. 573-882-1628

Research Interests

  • Host response to infectious disease

Areas of Expertise

  • Cellular Immunology
  • Autoimmunity and Tolerance
  • Bacterial Pathogenesis
  • Gene Expression
  • Immune Response to Pathogens
  • Innate Immunity
  • Inflammation
  • Bacteriology
  • Immunology

Education & Training

Post-Graduate School

1993, PhD, University of Chicago


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