David Pintel, PhD

Photo of David Pintel, PhD

Molecular Microbiology and Immunology

Dr. R. Philip and Diane Acuff Endowed Chair in Medical Research
Curators Distinguished Professor

573-882-3920

Profile

Dr. David Pintel has studied parvovirus molecular genetics and parvovirus‐host cell interactions productively for many years. Parvoviruses are important infectious agents, causing both persistent and acute infections of many animal species including humans. Additionally, parvoviruses, especially adeno-associated viruses (AAVs), have been developed as highly effective gene therapy tools, showing promise currently in numerous clinical trials. His work addresses critical aspects of parvovirus gene expression and replication, supports gene therapy applications, provides important insights into virus-host cell interactions including navigation of the host anti-viral response, and importantly, addresses fundamental aspects of cell biology in general. In this last regard, Dr. Pintel’s studies have revealed fundamental aspects of the regulation of alternative RNA processing, the relationship between nuclear RNA splicing and translation, the co-dependency of transcription and splicing, and aspects of the host cellular DNA damage response to infection.

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Lab Information

Academic Information

Dr. R. Philip and Diane Acuff Endowed Chair in Medical Research
Curators Distinguished Professor

Office

471F Bond Life Sciences Center
Columbia, MO 65211
United States

P. 573-882-3920

Research Interests

  • Virus-Host interactions
  • Virology and Molecular Therapies
  • Analysis of eukaryotic gene expression
  • Alternative RNA processing
  • Viral hijacking of the cellular DNA damage response

Areas of Expertise

  • Virology
  • Molecular Biology
  • Cell Biology
  • Gene Expression
  • Gene Therapy
  • Innate Immunity
  • RNA Biology
  • DNA damage and the cellular DNA damage response

Education & Training

Post-Graduate School

1979, PhD, University of Illinois

Publications

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