Profile
Dr. David Pintel has studied parvovirus molecular genetics and parvovirus‐host cell interactions productively for many years. Parvoviruses are important infectious agents, causing both persistent and acute infections of many animal species including humans. Additionally, parvoviruses, especially adeno-associated viruses (AAVs), have been developed as highly effective gene therapy tools, showing promise currently in numerous clinical trials. His work addresses critical aspects of parvovirus gene expression and replication, supports gene therapy applications, provides important insights into virus-host cell interactions including navigation of the host anti-viral response, and importantly, addresses fundamental aspects of cell biology in general. In this last regard, Dr. Pintel’s studies have revealed fundamental aspects of the regulation of alternative RNA processing, the relationship between nuclear RNA splicing and translation, the co-dependency of transcription and splicing, and aspects of the host cellular DNA damage response to infection.
In recognition of his contributions to understanding the life cycle of parvoviruses, in 2015 Pintel was named a fellow of the prestigious American Association for the Advancement of Science and elected fellow of the American Academy of Microbiology.
Lab Information
- Contact: Lisa Burger, 573-882-3171
- Lab members
- Former lab members
Academic Information
Office
471F Bond Life Sciences Center
Columbia, MO 65211
United States
Research Interests
- Virus-Host interactions
- Virology and Molecular Therapies
- Analysis of eukaryotic gene expression
- Alternative RNA processing
- Viral hijacking of the cellular DNA damage response
Areas of Expertise
- Virology
- Molecular Biology
- Cell Biology
- Gene Expression
- Gene Therapy
- Innate Immunity
- RNA Biology
- DNA damage and the cellular DNA damage response
Related Links
Education & Training
Post-Graduate School
1979, PhD, University of Illinois
Publications
- Dong Y, Fasina OO, PintelDJ. 2018. Minute Virus of Canines NP1 protein interacts with the cellular factor CPSF6 to regulate viral alternative RNA processing. J Virol. 2018 Oct 24. pii: JVI.01530-18. doi: 10.1128/JVI.01530-18. [Epub ahead of print] PMID:30355695
- Dong Y, Fasina OO, PintelDJ. 2018. The Human Bocavirus 1 NP1 Protein Is a Multifunctional Regulator of Viral RNA Processing. J Virol. 2018 Oct 29;92(22). pii: e01187-18. doi: 10.1128/JVI.01187-18. Print 2018 Nov 15. PMID:30135129
- Majumder K, Wang J, Boftsi M, Fuller MS, Rede JE, Joshi T, PintelDJ.2018. Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection. Elife. 2018 Jul 20;7. pii: e37750. doi: 10.7554/eLife.37750. PMID:30028293
- Majumder K, Etingov I, Pintel DJ. 2017. Protoparvovirus interactions with the cellular DNA damage response. Viruses. 2017 Oct 31;9(11). pii: E323. doi: 10.3390/v9110323. Review. PMID:29088070
- Fuller MS, Majumder K, Pintel DJ. 2017. Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection. J Virol. 2017 Jun 26;91(14). Pii:300428-17. Doi:10.1128/JVI.00428-17. Print 2017 Jul 15. PMID:29446681
- Fasina OO, Stupps S, Figueroa-Cuilan W, Pintel DJ. 2017. Minute Virus of Canines NP1 Protein Governs the Expression of a Subset of Essential Nonstructural Proteins via Its Role in RNA Processing. J Virol. 2017 May 26;91(12). Doi: 10.1128/JV.00260-17. Print 2017 Jun 15. PMID:28356522
- Mascarenhas JX, Korokhov N, Burger L, Kassim A, Tuter J, Miller D, Borgschulte T, George HJ, Chang A, Pintel DJ, Onions D, Kayser KJ. 2016. Genetic engineering of CHO cells for viral resistance to minute virus of mice. Biotechnol Bioeng. 2016 Sep 19. doi: 10.1002/bit.26186. [Epub ahead of print] PMID: 27642072
- Fasina OO, Dong Y, Pintel DJ. 2015. NP1 Protein of the Bocaparvovirus Minute Virus of Canines Controls Access to the Viral Capsid Genes via Its Role in RNA Processing. J Virol. 2015 Dec 4;90(4):1718-28. doi: 10.1128/JVI.02618-15. PMID:26637456
- Adeyemi, R.O. and J.Pintel. 2014. The ATR signaling pathway is disabled during infection by the parvovirus minute virus of mice.J Virol. 2014 Jun 25. pii: JVI.01412-14. [Epub ahead of print]PMID:24965470[PubMed - as supplied by publisher]
- Adeyemi, R.O., Fuller, M.S., and J. Pintel. 2014. Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNA.PLoS Pathog. 2014 Apr 3;10(4):e1004055. doi: 10.1371/journal.ppat.1004055. eCollection 2014 Apr.PMID: 24699724[PubMed - in process]
- Adeyemi, R.O., and D.J. Pintel. 2014. Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells. PLoS Pathog. 2014 Jan;10(1):e1003891. doi: 10.1371/journal.ppat.1003891. Epub 2014 Jan 9.PMID: 24415942 [PubMed - in process]
- Cotmore, S.F., Agbandje-McKenna, M., Chiorini, J.A., Mukha, D.V., Pintel, D.J., Qiu, J., Soderlund-Venermo, M., Tattersall, P., Tijssen, P., Gatherer, D., and A.J. Davison. 2014. The family Parvoviridae.Arch Virol. 2014 May;159(5):1239-47. doi: 10.1007/s00705-013-1914-1. Epub 2013 Nov 9.PMID:24212889[PubMed - indexed for MEDLINE]
- Sukhu, L., Fasina, O., Burger, L., Rai, A., Qiu, J., and D.J. Pintel. 2013. Characterization of the nonstructural proteins of the bocavirus minute virus of canines.J Virol. 2013 Jan;87(2):1098-104. doi: 10.1128/JVI.02627-12. Epub 2012 Nov 7.PMID:23135724[PubMed - indexed for MEDLINE]
- Fasina, O., and D.J. Pintel. 2013. The adeno-associated virus type 5 small rep proteins expressed via internal translation initiation are functional.J Virol. 2013 Jan;87(1):296-303. doi: 10.1128/JVI.02547-12. Epub 2012 Oct 17.PMID:23077303[PubMed - indexed for MEDLINE]