Deborah Chance is an Assistant Research Professor in the School of Medicine (SOM) in Molecular Microbiology & Immunology with joint appointment in Child Health. Dr. Chance collaborates with the College of Agriculture Regarding research dedicated, largely, to cystic fibrosis and cancer research. Her research emphases include researching better understanding of co-colonizing respiratory opportunistic pathogens and their survival tactics. This research is intended to help define new therapeutic strategies for chronic airway infections. Dr. Chance is involved in developing model systems in-house assessing the effects of bacterial products, and treatments targeting bacteria, on eukaryotic cells. She is also testing the effect of nutraceuticals, simple sugars, and other small molecules, in particular ones such as from essential oils, in providing antimicrobial or anti-virulence activities. Dr. Chance researches how these activities can be harnessed and used in new treatments of complex CF airway infections. Using clinically-minded basic research, often with patient specimens, she applies analytical, biochemical, molecular, microbiological, instrumental, and interdisciplinary skills to establish in vitro methods. These methods allow Dr. Chance to study the data from clinical situations encountered by patients and physicians when addressing chronic infection and its treatment in cystic fibrosis.
M616 Medical Sciences Bldg.
Columbia, MO 65212
- Bacterial Pathogenesis
- Chromatography/Mass Spectrometry
- Methods Development
Areas of Expertise
- Mucins and Pathogens in Cystic Fibrosis
- Heterogeneity, Virulence Factors, and Treatment of Opportunistic Pathogens in Cystic Fibrosis
- Imaging of Host‐Pathogen and Pathogen‐Pathogen Interactions
- Methods/Tools Development ‐ Analytical Biochemistry
- Cellular Biology
Education & Training
1997, PhD, Biochemistry, University of Missouri
1988, MS, Biochemistry, University of Missouri
1981, BS, Biology, Emory University
- Deborah L. Chance and Thomas P. Mawhinney, 2021. Observations of, and Insights into, Cystic Fibrosis Mucus Heterogeneity in the Pre-Modulator Era: Sputum Characteristics, DNA and Glycoprotein Content, and Solubilization Time, J. Respir. 2021, 1(1), 8-29; https://doi.org/10.3390/jor1010002
- Mawhinney TP, Li Y, Chance DL, Kelley SP, Mossine VV. Crystal structure of (R,S)-2-hy-droxy-4-(methyl-sulfan-yl)butanoic acid. Acta Crystallogr E Crystallogr Commun. 2020 Mar 17;76(Pt 4):562-566. doi: 10.1107/S2056989020003138. PMID: 32280504; PMCID: PMC7133032.
- Mossine, VV, Chance, DL, Waters, JK and TP Mawhinney. 2018. Interaction of Bacterial Phenazines with Colistimethate in Bronchial Epithelial Cells. Accepted manuscript posted online 21 May 2018, doi: 10.1128/AAC.02349-17.
- Chance DL, Mawhinney TP. 2017. Using Negative Staining TEM to Study Structure/Function Relationships of Cystic Fibrosis Host-Adapted Opportunistic Pathogen Pseudomonas aeruginosa. Microsc Microanal. 2017/08/04:1354-1355.
- Mossine VV, Waters JK, Chance DL, Mawhinney TP. 2016. Transient Proteotoxicity of Bacterial Virulence Factor Pyocyanin in Renal Tubular Epithelial Cells Induces ER-Related Vacuolation and Can Be Efficiently Modulated by Iron Chelators. Toxicol Sci. 154:403-415.
- Wang W, Lester JM, Amorosa AE, Chance DL, Mossine VV, Mawhinney TP. 2015. Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization. J Vis Exp. e52922
- Chance DL, Mossine VV, Waters JK, Mawhinney TP. 2014.In VitroInvestigations of Potential Synergistic Effects of Antimicrobial Essential Oils and Constituents with Antibiotics for Treating CF Airway Infections. Pediatric Pulmonology. 49:339-339.