Deborah Chance, PhD


Deborah Chance is an Assistant Research Professor in the School of Medicine (SOM) in Molecular Microbiology & Immunology with joint appointment in Pediatrics. Dr. Chance collaborates with the College of Agriculture Regarding research dedicated, largely, to cystic fibrosis and cancer research. Her research emphases include researching better understanding of co-colonizing respiratory opportunistic pathogens and their survival tactics. This research is intended to help define new therapeutic strategies for chronic airway infections. Dr. Chance is involved in developing model systems in-house assessing the effects of bacterial products, and treatments targeting bacteria, on eukaryotic cells. She is also testing the effect of nutraceuticals, simple sugars, and other small molecules, in particular ones such as from essential oils, in providing antimicrobial or anti-virulence activities. Dr. Chance researches how these activities can be harnessed and used in new treatments of complex CF airway infections. Using clinically-minded basic research, often with patient specimens, she applies analytical, biochemical, molecular, microbiological, instrumental, and interdisciplinary skills to establish in vitro methods. These methods allow Dr. Chance to study the data from clinical situations encountered by patients and physicians when addressing chronic infection and its treatment in cystic fibrosis.

Academic Information

Adjunct Assistant Research Professor


M616 Medical Sciences Bldg.
Columbia, MO 65212
United States

P. 573-268-8102

Research Interests

  • Microbiology
  • Bacterial Pathogenesis
  • Chromatography/Mass Spectrometry
  • Methods Development

Areas of Expertise

  • Mucins and Pathogens in Cystic Fibrosis
  • Heterogeneity, Virulence Factors, and Treatment of Opportunistic Pathogens in Cystic Fibrosis
  • Imaging of Host‐Pathogen and Pathogen‐Pathogen Interactions
  • Methods/Tools Development ‐ Analytical Biochemistry
  • Cellular Biology

Education & Training

Post-Graduate School

1997, PhD, Biochemistry, University of Missouri


1988, MS, Biochemistry, University of Missouri


1981, BS, Biology, Emory University


Selected publications

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