Diana Gil Pagés, PhD


Dr. Diana Gil Pagés’ research investigates how antigen recognition by T cell receptors (TCRs) turns on cell adaptive immune function. Specifically, she is focused on the TCR-associated CD3 multiprotein complex and is the principal discoverer of the CD3 conformational change (CD3Dc) which is at the foundation of her ongoing research. Dr. Gil Pagés is studying the various levels of control exercised over CD3Dc, including structural, biochemical, developmental and physiological aspects. Her work is grounded in technical innovation and data reproducibility with an emphasis in biochemistry and primary immune cell function. She is building on the current understanding of CD3Dc to translate knowledge into in vivo therapies for metastatic cancers with focus areas on fragment antigen-binding (Fab) fragments.

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Academic Information

Associate Professor


1 Hospital Drive
Columbia, MO 65212
United States

Research Interests

  • Immunology
  • Adaptive immune responses
  • T cell development and maturation
  • Central and peripheral tolerance
  • Inflammation
  • Antigen receptors structures and function
  • Antigen presentation
  • Intracellular trafficking
  • TCR/CD3 signal transduction
  • Tumor immunology
  • Cancer immunotherapies
  • Autoimmunity
  • Development of novel therapeutics targeting T cells

Areas of Expertise

  • Immunology
  • Adaptive Immune Response
  • Structure/function of antigen receptors
  • Antigen presentation
  • TCR/CD3 Signal transduction
  • T cell development
  • Central and peripheral tolerance
  • Cancer immunotherapies
  • Development of novel cancer immunotherapies

Education & Training


2007, University Hospital, Basel, Switzerland

Post-Graduate School

2002, PhD, Universidad Autonoma de Madrid

In the News


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