Profile
Dr. Diana Gil Pagés’ research investigates how antigen recognition by T cell receptors (TCRs) turns on cell adaptive immune function. Specifically, she is focused on the TCR-associated CD3 multiprotein complex and is the principal discoverer of the CD3 conformational change (CD3Dc) which is at the foundation of her ongoing research. Dr. Gil Pagés is studying the various levels of control exercised over CD3Dc, including structural, biochemical, developmental and physiological aspects. Her work is grounded in technical innovation and data reproducibility with an emphasis in biochemistry and primary immune cell function. She is building on the current understanding of CD3Dc to translate knowledge into in vivo therapies for metastatic cancers with focus areas on fragment antigen-binding (Fab) fragments.
Academic Information
Office
1030 Hitt St
Room 2015 NextGen Precision Health Institute
Columbia, MO 65211
United States
Research Interests
- Immunology
- Adaptive immune responses
- T cell development and maturation
- Central and peripheral tolerance
- Inflammation
- Antigen receptors structures and function
- Antigen presentation
- Intracellular trafficking
- TCR/CD3 signal transduction
- Tumor immunology
- Cancer immunotherapies
- Autoimmunity
- Development of novel therapeutics targeting T cells
Areas of Expertise
- Immunology
- Adaptive Immune Response
- Structure/function of antigen receptors
- Antigen presentation
- TCR/CD3 Signal transduction
- T cell development
- Central and peripheral tolerance
- Cancer immunotherapies
- Development of novel cancer immunotherapies
Education & Training
Fellowship
2007, University Hospital, Basel, Switzerland
Post-Graduate School
2002, PhD, Universidad Autonoma de Madrid
In the News
Publications
- Goplen NP, Saxena V, Knudson KM, Schrum AG, Gil D, Daniels MA, Zamoyska R, Teixeiro E. 2016. IL-12 Signals through the TCR To Support CD8 Innate Immune Responses. J Immunol. 2016 Sep 15; 197(6):2434-43. doi: 10.4049/jimmunol.1600037. Epub 2016 Aug 12. PMID: 27521342
- Smith SE, Neier SC, Reed BK, Davis TR, Sinnwell JP, Eckel-Passow JE, Sciallis GF, Wieland CN, Torgerson RR, Gil D, Neuhauser C, Schrum AG. 2016. Multiplex matrix network analysis of protein complexes in the human TCR signalosome. Sci Signal. 2016 Aug 2;9(439):rs7. doi: 10.1126/scisignal.aad7279. PMID: 27485017
- Smith SE, Maus RL, Davis TR, Sundberg JP, Gil D, Schrum AG. 2016. Maternal IL-6 can cause T-cell-mediated juvenile alopecia by non-scarring follicular dystrophy in mice. Exp Dermatol. 2016 Mar;25(3):223-8. doi: 10.1111/exd.12914. Epub 2016 Feb 10. PMID: 2666033
- Hoffmann MM, Molina-Mendiola C, Nelson AD, Parks CA, Reyes EE, Hansen MJ, Rajagopalan G, Pease LR, Schrum AG, Gil D. 2015. Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo. Sci Adv. 2015 Oct 2;1(9):e1500415. doi: 10.1126/sciadv.1500415. eCollection 2015 Oct. PMID: 26601285
- Reed BK, Chopp LB, Malo CS, Renner DN, Van Keulen VS, Girtman MA, Nevala WN, Pavelko KD, Gil D,Schrum AG, Johnson AJ, Pease LR. 2015. A Versatile Simple Capture Assay for Assessing the Structural Integrity of MHC Multimer Reagents. PLoS One. 2015 Sep 21;10(9):e0137984. doi: 10.1371/journal.pone.0137984. eCollection 2015. PMID: 26389800
- Reed BK, Lee KA, Bell MP, Gil D, Schrum AG. 2014. Detection of constant domain of human T cell antigen receptor alpha-chain via novel monoclonal antibody 7F18. Monoclon Antib Immunodiagn Immunother. 2014 Dec;33(6):386-92. doi: 10.1089/mab.2013.0086. PMID: 25545207
- Smith SE, Nei7er SC, Davis TR, Pittelkow MR, Gil D, Schrum AG. 2014. Signaling protein complexes isolated from primary human skin-resident T cells can be analysed by Multiplex IP-FCM. Exp Dermatol. 2014 Apr;23(4):272-3. doi: 10.1111/exd.12362. PMID: 24588717