Profile
Dr. Shin studies computational methods in biomedicine. He leads the Translational and Cancer Bioinformatics laboratory at the MU School of Medicine. His primary research area is advanced computerized inference methods in personalized medicine. In his most recent work, Dr. Shin introduced the field of computational morphoproteomics in which visual patterns of protein expression from WSI immunohistochemical studies are used to infer complex interplay of signal transduction pathways to design effective combinatorial therapies for theranostics. Additionally, Dr. Shin has lead the Informatics/IT division of MU Pathology and Anatomical Sciences department for over 10 years. Under his leadership, new computer systems have been designed, implemented and supported, including ANA, flow cytometry, bone marrow, molecular pathology laboratory information systems and biorepository software, pathology digital dictation system, and high definition microscopy telepathology system. He has been involved in many aspects of PAS department operations, including outreach medical examiners services, and development of electronic teaching materials for anatomy and pathology education. Recently Dr. Shin established Whole Slide Image Analytics laboratory, providing services for researchers and medical practitioners. WSI lab members are currently developing online WSI hematopathology and histology atlases in collaboration with Dr. Richard Hammer, MD, Dr. Donald Doll, MD and Dr. Krause, PhD. Dr. Shin along with Dr. Jeff Bryan and Richard Hammer leads a campus-wide Data-Driven Precision Medicine initiative.
Academic Information
Research Interests
- Precision Medicine Informatics
- Translational and Cancer Bioinformatics
- Biomedical Imaging Informatics
- Pathology Informatics.
Education & Training
Post-Graduate School
M.Sc., Computer Science, Moscow State Academy of Computer Science and Engineering; Ph.D., Biomedical Informatics, University of Missouri
Publications
- Shin D*, Arthur G, Popescu M, Korkin D, Shyu C, Uncovering influence links in molecular knowledge networks to streamline personalized medicine. J Biomed Inform (2014), http://dx.doi.org/10.1016/j.jbi.2014.08.0034
- D. Shin*, E. Rogatsky, A. Stoyanov*, “Simultaneous monitoring of multiple transitions in mass spectrometric analysis improves limit of detection for low abundance substances in complex biological samples.” J Chromatograph Separat Techniq 4: 206. doi:10.4172/2157- 7064.1000206, 2014
- Chen Z, Shin D, Chen S, Mikhail K, Hadass O, et al. (2014) Histological Quantitation of Brain Injury Using Whole Slide Imaging: A Pilot Validation Study in Mice. PLoS ONE 9(3): e92133. doi:10.1371/journal.pone.0092133
- Orr Hadass, Brittany N. Tomlinson, Major Gooyit, Shanyan Chen, Justin J. Purd, Jennifer M. Walker, Chunyang Zhang, Andrew B. Giritharan, Whitley Purnell, Christopher R. Robinson, Dmitriy Shin, Valerie A. Schroeder, Mark A. Suckow, Agnes Simonyi, Grace Y. Sun, Shahriar Mobashery, Jiankun Cui, Mayland Chang*, Zezong Gu*, “Selective Inhibition of Matrix Metalloproteinase-9 Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury.”, PLOS One, 2013, 8:10
- D. Shin*, G. Arthur, C. Caldwell, M. Popescu, M. Petruc, A. Diaz-Arias, and C. Shyu, “A pathologist-in-the-loop IHC antibody test selection using the entropy-based probabilistic method,” Journal of Pathology Informatics, vol. 3, no. 1, p. 1, 2012.
- Multi-resolution tile-based follicle detection using color and textural information of follicular lymphoma IHC slides Han J., Shin D., Arthur G., Shyu C., BIBM, 2010