Guanghong Jia, PhD

Guanghong Jia, PhD, is an endocrinology researcher in the Department of Medicine whose work focuses on understanding the mechanisms linking insulin resistance to changes in vascular function and target organ dysfunction. Specifically, his work has identified the importance of endothelial mineralocorticoid receptors and epithelial sodium channels in connecting dietary and hormonal factors to the pathogenesis of arterial stiffening and vascular insulin resistance, which highlights their potential as therapeutic targets. Dr. Jia has also investigated endothelial function, adipose tissue plasticity and skeletal muscle insulin sensitivity, focusing on how Western diet-induced obesity alters cellular metabolism. Using transgenic mouse models, he has explored inter-organ crosstalk and the mechanisms underlying cardiometabolic syndrome.