Profile
Guanghong Jia, PhD, is an endocrinology researcher in the Department of Medicine whose work focuses on understanding the mechanisms linking insulin resistance to changes in vascular function and target organ dysfunction. Specifically, his work has identified the importance of endothelial mineralocorticoid receptors and epithelial sodium channels in connecting dietary and hormonal factors to the pathogenesis of arterial stiffening and vascular insulin resistance, which highlights their potential as therapeutic targets. Dr. Jia has also investigated endothelial function, adipose tissue plasticity and skeletal muscle insulin sensitivity, focusing on how Western diet-induced obesity alters cellular metabolism. Using transgenic mouse models, he has explored inter-organ crosstalk and the mechanisms underlying cardiometabolic syndrome.
Academic Information
Office
1 Hospital Dr
Center for Precision Medicine
Columbia, MO 65212
United States
Areas of Expertise
- Vascular biology
- Hypertension
- Obesity and lipid metabolic disorders
- Skeletal muscle insulin resistance
Education & Training
Degrees
PhD, Huazhong University of Science and Technology, China
Fellowship, Creighton University School of Medicine, Omaha, NE
Awards & Honors
2025 Fellow of the American Heart Association (FAHA)
2016 Innovative Basic Science Award, American Diabetes Association
2015 Internal Medicine Research Award, University of Missouri School of Medicine
Grants and Contract Awards
Agency: NIH/NHLBI R01HL172875
Title: Epithelial sodium channels in endothelial cells and arterial stiffening
Period: 04/01/2024-03/31/2028
Role: Contact PI
Agency: NIH/NIDDK R01DK124329
Title: Endothelial mineralocorticoid receptors in diet-induced skeletal muscle insulin resistance
Period: 12/01/2020 - 11/30/2025
Role: PI
Agency: American Diabetes Association, Innovative Basic Science Award #1-17-IBS-201
Title: Endothelial mineralocorticoid receptors in insulin resistance and vascular function
Period: 01/01/2017-12/31/2019
Role: PI