Jorge Gomez-Gutierrez, PhD

Jorge Gomez-Gutierrez, PhD

Pediatrics

Associate Professor of Pediatrics
NextGen Precision Health Investigator

573-882-9520

Profile

The Gomez-Gutierrez Laboratory is primarily interested in microbial-based cancer therapy. Dr. Gomez-Gutierrez, PhD focuses on investigating how virus- and bacteria-based therapies can be used to stop tumorigenesis and induce oncolysis and/or immune responses in cancers when conventional therapy is inadequate. Two microorganisms are being studied: the first is a conditionally replicating adenovirus (CRAd) also known as oncolytic adenovirus (OAd); the second is the lactic acid bacteria Lactococcus lactis (L. lactis), which is generally regarded as a safe (GRAS) organism and is used in dairy industry to make cheese and yogurt. The former study was funded with an NIH/NCI exploratory/developmental grant R21CA210202 and currently supported by Burroughs Wellcome Fund.

Academic Information

Associate Professor of Pediatrics
NextGen Precision Health Investigator

Office

1201 E Rollins St
Room 340b
Columbia, MO 65201
United States

P. 573-882-9520

Education & Training

Post-Graduate School

2006, PhD, University of Nuevo León
2001, BS University of Nuevo León

Awards & Honors

  • 2000 First Place, XVIII National Congress of Biomedical Research, Mexico.
  • 2001 First Place, Tecnos Award, Mexico
  • 2001 Third Place, XIX National Congress Biomedical Research, Mexico
  • 2001 PhD Scholarship Award Recipient, National Council of Science and Technology (CONACYT) of Mexico
  • 2002 First Place, Youth National Meeting of Science and Technology, Mexico
  • 2008 Distinction Recipient of Candidate to National System of Researchers, (CONACYT) of Mexico
  • 2011 Research Award in the Health Science Area for the manuscript published in Cancer 2010, 15;116(18):4420-32, Autonomous University of Nuevo Leon (UANL, Spanish), Mexico.
  • 2011 Ralph Scott Postdoctoral Fellow Research Prize, 3rd Place, James Graham Brown Cancer Center, Tenth Annual Retreat
  • 2012 Clinical Fellow Research Prize, 1st Place, Michael Egger (Presenter) and Gomez-Gutierrez JG (Project Director), James Graham Brown Cancer Center Eleventh Annual Retreat
  • 2013 Distinction Recipient of National Researcher Level I, National System of Researchers (CONACYT) of Mexico
  • 2014 NCI Cancer Education Program Norbert J. Burzynski Award, Professional Student Category 2nd Place, Eric Riedinger (Presenter) and Gomez-Gutierrez JG, Project Director, Research Louisville
  • 2015 Partner Travel Research Scholarship (University of Louisville-Cornell University) recipient to attend the Society of Advancement of Chicanos and Native Americans in Science (SACNAS) National Conference, Washington DC (Poster). Perez-Hernandez R. (Presenter), Gomez-Gutierrez JG (Project Director).
  • 2015 Best Master Thesis Award in the Health Science Area, Elvis Martinez-Jaramillo (Student) and Gomez-Gutierrez JG (External Project Director). Autonomous University of Nuevo Leon (UANL, Spanish), Mexico
  • 2016 Research Award in the Health Science Area for the Master Thesis of Elvis Martinez-Jaramillo, Gomez-Gutierrez JG (External Project Director). Autonomous University of Nuevo Leon (UANL, Spanish), Mexico.
  • 2017 Distinction Recipient of National Researcher Level II, National System of Researchers (CONACYT) of Mexico.
  • 2017 NCI Cancer Education Program Norbert J. Burzynski Award, Underdgraduate Student Category 2nd Place, Roxana Gonzalez-Ramos (Presenter) and Gomez-Gutierrez JG (Project Director), Research Louisville 2017
  • 2018 NCI Cancer Education Program Norbert J. Burzynski Award, Underdgraduate Student Category 2nd Place, Alana Gipson (Presenter) and Gomez-Gutierrez JG (Project Director), Research Louisville 2018
  • 2019 Research Associate Award, 1st Place, Rodolfo Garza-Morales (Presenter) and Gomez-Gutierrez JG (Project Director), Research Louisville 2019.
  • 2019 Louisville Chapter-Women in Medicine and Science Award, 3rd place, Lilibeth Lanceta (Presenter), Gomez-Gutierrez JG (Co-author), Research Louisville 2019.

In the News

Probiotic intestines illustration

Publications

PEER-REVIEWED

  • Gomez-Gutierrez JG, Souza V, Hao HY, Montes de Oca-Luna R, Dong YB, Zhou SH, McMasters KM. Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma Cells. Cancer Biol Ther 5 (7); 867-874. 2006. (cited 61 times).
  • Gomez-Gutierrez JG, Elpek KG, Montes de Oca-Luna R, Shirwan H, Zhou SH, McMasters KM. Vaccination with an adenoviral vector expressing calreticulin-human papillomavirus 16 E7 fusion protein eradicates E7 expressing established tumors in mice. Cancer Immunol Immunother 56: 997-1007. 2007. (cited 78 times).
  • Hao HY, Dong YB, Bowling MT, Gomez-Gutierrez JG, Zhou HS, McMasters KM. E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation. BMC Cancer 7: 24. 2007. (cited 34 times).
  • Dong YB, Phelps AM, Yang HL, Jamshidi-Parsian A, Chen C, Hao HY, Gomez-Gutierrez JG, Zhou HS, McMasters KM. Induction of apoptosis signal-regulating kinase 1 by E2F-1 may not be essential for E2F-1-medieted apoptosis in melanoma cells. Tumor Biol 28: 111-122. 2007. (cited 10 times).
  • Zheng X, Rao X-M, Gomez-Gutierrez JG. Hao HY, McMasters K. M., and Zhou H. S. Adenovirus E1B55K region is required for inducing cyclin E expression for efficient viral DNA replication in G0-arrested cells. J Virol 82; 7: 3415-27. 2008. (cited 47 times).
  • Villatoro-Hernandez J, Loera-Arias MJ, Gamez-Escobedo A, Franco-Molina M, Gomez-Gutierrez JG, Rodriguez-Rocha H, Gutierrez-Puente Y, Saucedo-Cardenas O, Valdes-Flores J, Montes-de-Oca-Luna R. Secretion of biologically active Interferon-gamma inducible protein-10 (IP-10) by Lactococcus lactis. Microb Cell Fact. 28; 7(1):22. 2008. (cited 29 times).
  • Gomez-Gutierrez JG, Rao XM, Garcia-Garcia A, Hao H, McMasters KM, Zhou HS. Developing adenoviral vectors encoding therapeutic genes toxic to host cells: comparing binary and single-inducible vectors expressing truncated E2F-1. Virology. 20; 397(2):337-45. 2010. (cited 8 times).
  • Gomez-Gutierrez JG, Garcia-Garcia A, Hao H, Rao XM, Montes de Oca-Luna R, Zhou HS, McMasters KM. Adenovirus-mediated expression of truncated E2F-1 suppresses tumor growth in vitro and in vivo. Cancer. 116(18):4420-32. 2010. (cited 15 times).
  • Rodriguez-Rocha H, Gomez-Gutierrez JG, Garcia-Garcia A, Rao X-M, Chen L, McMasters KM, Zhou HS. Adenoviruses Induce Autophagy to Promote Virus Replication and Oncolysis. Virology. 416(1-2):9-15.2011 (cited 87 times, first and second authors contributed equally in this study).
  • Hao H, Chen C, Rao XM, Gomez-Gutierrez JG, Zhou HS, McMasters KM. E2F-1- and E2Ftr-mediated apoptosis: the role of DREAM and HRK. J Cell Mol Med. 16(3):605-15.2012. (cited 9 times).
  • Garcia-Garcia A, Rodriguez-Rocha H, Tseng MT, Montes de Oca-Luna R, Zhou HS, McMasters KM, Gomez-Gutierrez JG. E2F-1 lacking the transcriptional activity domain induces autophagy. Cancer Biol Ther. 1; 13 (11). 2012. (cited 15 times, corresponding author).
  • Gomez-Gutierrez JG, Egger ME, Hao H, Zhou HS, McMasters KM. Adenovirus-mediated expression of mutated forkhead human transcription like-1 suppresses tumor growth in a mouse melanoma xenograft model. Cancer Biol Ther. 1; 13 (12). 2012. (First and corresponding author).
  • Gomez-Gutierrez JG, Rao X-M, Zhou HS, McMasters KM. Enhanced cancer cell killing by truncated E2F-1 used in combination with oncolytic adenovirus. Virology. 433 (2): 538-547. 2012.
  • Egger ME, McNally LR, Nitz J., McMasters KM, Gomez-Gutierrez JG. Adenovirus-mediated FKHRL1/TM sensitizes melanoma cells to apoptosis induced by temozolomide. Hum Gene Ther Clin Dev. 25 (3): 186-95. 2014. (Corresponding author).
  • Rangel-Colmenero BR, Gomez-Gutierrez JG, Villatoro-Hernández J, Zavala-Flores LM, Quistián-Martínez D, Rojas-Martínez A, Arce-Mendoza AY, Guzmán-López S, Montes-de-Oca-Luna R, Saucedo- Cárdenas O. Enhancement of Ad-CRT/E7-mediated antitumor effect by preimmunization with L. lactis expressing HPV-16 E7. Viral Immunol. 27(9):463-7. 2014. (This was featured article on the journal cover of Viral Immunology November 2014. First and second authors contributed equally in this study).
  • Yin W, Kimbrough CW, Gomez-Gutierrez JG, Burns CT, Chuong P, Grizzle WE, McNally LR. Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography. J Nanobiotechnology. 2015;13:90.
  • Gomez-Gutierrez JG, Nitz J, Sharma R, Wechman SL, Riedinger E, Martinez-Jaramillo E, Sam Zhou H, McMasters KM. Combined therapy of oncolytic adenovirus and temozolomide enhances lung cancer virotherapy in vitro and in vivo. Virology. 2016;487:249-59. (First and corresponding author, cited 9 times).
  • Sharma RK, Chheda ZS, Das Purkayastha BP, Gomez-Gutierrez JG, Jala VR, Haribabu B. A spontaneous metastasis model reveals the significance of claudin-9 overexpression in lung cancer metastasis. Clin Exp Metastasis. 2016;33(3):263-75.
  • Wechman SL, Rao XM, Cheng PH, Gomez-Gutierrez JG, McMasters KM, Zhou HS. Development of an Oncolytic Adenovirus with Enhanced Spread Ability through Repeated UV Irradiation and Cancer Selection. Viruses. 2016. 14;8(6). pii: E167.
  • Martinez-Jaramillo E, Garza-Morales R, Loera-Arias MJ, Saucedo-Cardenas O, Montes-de-Oca-Luna R, McNally LR, Gomez-Gutierrez JG. Development of Lactococcus lactis encoding fluorescent proteins, GFP, mCherry and iRFP regulated by the nisin-controlled gene expression system. Biotech Histochem. 2017;92(3):167-174. (Corresponding author).
  • Garza-Morales R, Yaddanapudi K, Perez-Hernandez R, Riedinger E, McMasters KM, Shirwan H, Yolcu E, Gomez-Gutierrez JG. Temozolomide renders murine cancer cells susceptible to oncolytic adenovirus replication and oncolysis. Cancer Biol Ther. 2018. 4;19(3):188-197. (Corresponding author).
  • Martinez-Jaramillo E, Garza-Morales R, Wechman SL, Montes de Oca-Luna R, Saucedo-Cardenas O, Shirwan H, Yolcu E, McMasters KM, Gomez-Gutierrez JG. Adenovirus Lacking E1b Efficiently Induces Cytopathic Effect in HPV-16-Positive Murine Cancer Cells via Virus Replication and Apoptosis. Cancer Invest. 2018. 2;36(1):19-27. (Corresponding author).
  • Garza-Morales R, Gonzalez-Ramos R, Chiba A, Montes de Oca-Luna R, McNally LR, McMasters KM, Gomez-Gutierrez JG. Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro. Cancers (Basel). 2018. 17;10(5). pii: E144. (Corresponding author).
  • Wechman SL, Rao XM, Gomez-Gutierrez JG, Zhou HS, McMasters KM. The role of JNK phosphorylation as a molecular target to enhance adenovirus replication, oncolysis and cancer therapeutic efficacy. Cancer Biol Ther. 2018. 1:1-11. doi: 10.1080/15384047.2018.1491503.
  • Garza-Morales R, Perez-Trujillo JJ, Martinez-Jaramillo E, Saucedo-Cardenas O, Loera-Arias MJ, Garcia-Garcia A, Rodriguez-Rocha H, Yolcu E, Shirwan H, Gomez-Gutierrez JG, and Montes de Oca-Luna R. A DNA vaccine encoding SA-4-1BBL fused to HPV-16 E7 antigen has prophylactic and therapeutic efficacy in a cervical cancer mouse model. Cancers 2019, 11(1), 96; https://doi.org/10.3390/cancers11010096. (Corresponding author)
  • Barsoumian HB, Batra L, Shrestha P, Bowen WS, Zhao H, Egilmez NK, Gomez-Gutierrez JG, Yolcu ES, and Shirwan H. A novel form of 4-1BBL as a single agent prevents cancer development via non-specific activation of CD4+ T and Natural Killer cells. Cancer Res. 2019 Feb 15;79(4):783-794. doi: 10.1158/0008-5472.CAN-18-2401. PMID:30770367. 27. Lypova N, Lanceta L, Gibson A, Vega S, Garza-Morales R, McMasters KM, Chesney J, Gomez-Gutierrez JG, Imbert-Fernandez Y. Targeting Palbociclib-Resistant Estrogen Receptor-Positive Breast Cancer Cells via Oncolytic Virotherapy. Cancers (Basel). 2019 May 16;11(5). pii: E684. doi: 10.3390/cancers11050684. PMID:31100952.
  • Garza-Morales R, Rendon BE, Malik MT, Garza-Cabrales JE, Aucouturier A, Bermúdez-Humarán LG, McMasters KM, McNally LR and Gomez-Gutierrez JG. Targeting Melanoma Hypoxia with the Food-Grade Lactic Acid Bacterium Lactococcus Lactis. Cancers 2020, 12(2), 438; https://doi.org/10.3390/cancers12020438. (Corresponding author).
  • Lanceta L, O'Neill C, Lypova N, Li X, Rouchka E, Waigel S, Gomez-Gutierrez JG, Chesney J, Imbert-Fernandez Y. Transcriptomic Profiling Identifies Differentially Expressed Genes in Palbociclib-Resistant ER+ MCF7 Breast Cancer Cells. Genes (Basel). 2020 Apr 24;11(4):467. doi: 10.3390/genes11040467. PMID: 32344635.
  • Gomez-Gutierrez JG, Bhutiani N, McNally MW, Chuong P, Yin W, Jones MA, Zeiderman MR, Grizzle WE, McNally LR. The neutral red assay can be used to evaluate cell viability during autophagy or in an acidic microenvironment in vitro. Biotech Histochem. 2020 Aug 3:1-9. doi: 10.1080/10520295.2020.1802065. Online ahead of print. PMID: 32744455.
  • Thomas A, Samykutty A, Gomez-Gutierrez JG, Yin W, Egger ME, McNally M, Chuong P, MacCuaig WM, Albeituni S, Zeiderman M, Li M, Edil BH, Grizzle WE, McMasters KM, McNally LR. Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo. Cancers (Basel). 2020 Aug 14;12(8):2279. doi: 10.3390/cancers12082279. PMID: 32823919.

NON-PEER-REVIEWED

  • Gómez Gutiérrez JG, Bermúdez Humarán LG, Ruiz Trejo D, Taméz Guerra R, Montes de Oca Luna R. Production and Isolation of the Taq DNA polymerase from recombinant E. coli. Ciencia, UANL (Spanish). 2002; 3:316-321.

Book Chapter

  • Borovjagin AV, Gomez-Gutierrez JG, Shirwan H, Matthews QL. Adenovirus-based vectors for the development of prophylactic and therapeutic vaccines. In: Lukashevic I, Shirwan H, eds. Novel technologies for vaccine development. Berlin: Springer Verlag, 2014:pp. 203-271.
  • Marơnez-Jaramillo E, Gómez Gutiérrez JG, Loera MJ, Saucedo Cárdenas O, Montes de Oca Luna R. Development of murine cellular system for the analysis of oncolytic adenovirus antitumor activity. Ciencia UANL (Spanish). 2017; 83: 56-61.

See a complete publications list