Profile
The Gomez-Gutierrez Laboratory is primarily interested in microbial-based cancer therapy. Dr. Gomez-Gutierrez, PhD focuses on investigating how virus- and bacteria-based therapies can be used to stop tumorigenesis and induce oncolysis and/or immune responses in cancers when conventional therapy is inadequate. Two microorganisms are being studied: the first is a conditionally replicating adenovirus (CRAd) also known as oncolytic adenovirus (OAd); the second is the lactic acid bacteria Lactococcus lactis (L. lactis), which is generally regarded as a safe (GRAS) organism and is used in dairy industry to make cheese and yogurt. The former study was funded with an NIH/NCI exploratory/developmental grant R21CA210202 and currently supported by Burroughs Wellcome Fund.
Academic Information
Associate Professor of Pediatrics
NextGen Precision Health Investigator
Office
1030 Hitt Street
Columbia, MO 65211
United States
P. 502-396-8117
Research Interests
- Microbial based immunotherapies
- Cancer immunology and imaging
Areas of Expertise
- recombinant probiotic bacterium
- oncolytic adenovirus-based cancer virotherapy
- advanced molecular imaging
- multispectral optoacoustic tomography
Education & Training
Post-Graduate School
2006, PhD, University of Nuevo León
2001, BS University of Nuevo León
Degrees
2006 PhD, Autonomous University of Nuevo Leon
Awards & Honors
- 2025 Health Science Research Day, First Place, Poster Presentation, Translational Science Category II. Rubio-Infante N (Presenter), Gomez-Gutierrez JG (Project Director).
- 2025 AACR Minority and Minority-Serving Institution Faculty Scholar in Cancer Research Award
- 2022 AACR Minority and Minority-Serving Institution Faculty Scholar in Cancer Research Award
- 2000 First Place, XVIII National Congress of Biomedical Research, Mexico.
- 2001 First Place, Tecnos Award, Mexico
- 2001 Third Place, XIX National Congress Biomedical Research, Mexico
- 2001 PhD Scholarship Award Recipient, National Council of Science and Technology (CONACYT) of Mexico
- 2002 First Place, Youth National Meeting of Science and Technology, Mexico
- 2008 Distinction Recipient of Candidate to National System of Researchers, (CONACYT) of Mexico
- 2011 Research Award in the Health Science Area for the manuscript published in Cancer 2010, 15;116(18):4420-32, Autonomous University of Nuevo Leon (UANL, Spanish), Mexico.
- 2011 Ralph Scott Postdoctoral Fellow Research Prize, 3rd Place, James Graham Brown Cancer Center, Tenth Annual Retreat
- 2012 Clinical Fellow Research Prize, 1st Place, Michael Egger (Presenter) and Gomez-Gutierrez JG (Project Director), James Graham Brown Cancer Center Eleventh Annual Retreat
- 2013 Distinction Recipient of National Researcher Level I, National System of Researchers (CONACYT) of Mexico
- 2014 NCI Cancer Education Program Norbert J. Burzynski Award, Professional Student Category 2nd Place, Eric Riedinger (Presenter) and Gomez-Gutierrez JG, Project Director, Research Louisville
- 2015 Partner Travel Research Scholarship (University of Louisville-Cornell University) recipient to attend the Society of Advancement of Chicanos and Native Americans in Science (SACNAS) National Conference, Washington DC (Poster). Perez-Hernandez R. (Presenter), Gomez-Gutierrez JG (Project Director).
- 2015 Best Master Thesis Award in the Health Science Area, Elvis Martinez-Jaramillo (Student) and Gomez-Gutierrez JG (External Project Director). Autonomous University of Nuevo Leon (UANL, Spanish), Mexico
- 2016 Research Award in the Health Science Area for the Master Thesis of Elvis Martinez-Jaramillo, Gomez-Gutierrez JG (External Project Director). Autonomous University of Nuevo Leon (UANL, Spanish), Mexico.
- 2017 Distinction Recipient of National Researcher Level II, National System of Researchers (CONACYT) of Mexico.
- 2017 NCI Cancer Education Program Norbert J. Burzynski Award, Underdgraduate Student Category 2nd Place, Roxana Gonzalez-Ramos (Presenter) and Gomez-Gutierrez JG (Project Director), Research Louisville 2017
- 2018 NCI Cancer Education Program Norbert J. Burzynski Award, Underdgraduate Student Category 2nd Place, Alana Gipson (Presenter) and Gomez-Gutierrez JG (Project Director), Research Louisville 2018
- 2019 Research Associate Award, 1st Place, Rodolfo Garza-Morales (Presenter) and Gomez-Gutierrez JG (Project Director), Research Louisville 2019.
- 2019 Louisville Chapter-Women in Medicine and Science Award, 3rd place, Lilibeth Lanceta (Presenter), Gomez-Gutierrez JG (Co-author), Research Louisville 2019.
In the News
Publications
- Ramos-Gonzalez MR, Sirpu Natesh N, Rachagani S, Amos-Landgraf J, Shirwan H, Yolcu ES, Gomez-Gutierrez JG, et al.
Establishment of Translational Luciferase-Based Cancer Models to Evaluate Antitumoral Therapies.
Int J Mol Sci. 2024 Sep 27;25(19):10418. - Ramos-Gonzalez MR, Tarique M, Batra L, Arguc F, Garza-Morales R, Shirwan H, Yolcu ES, Gomez-Gutierrez JG.
Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth.
Vaccines (Basel). 2024 Mar 21;12(3):340. - Martinez-Perez AG, Perez-Trujillo JJ, Garza-Morales R, Ramirez-Avila NE, Loera-Arias MJ, Gomez-Gutierrez JG, et al.
An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model.
Vaccines (Basel). 2021 Feb 12;9(2):149. - Lanceta L, O’Neill C, Lypova N, Li X, Rouchka E, Waigel S, et al.
Transcriptomic Profiling Identifies Differentially Expressed Genes in Palbociclib-Resistant ER+ MCF7 Breast Cancer Cells.
Genes (Basel). 2020 Apr 24;11(4):467. - Garza-Morales R, Perez-Trujillo JJ, Martinez-Jaramillo E, Saucedo-Cardenas O, Loera-Arias MJ, Garcia-Garcia A, et al.
A DNA Vaccine Encoding SA-4-1BBL Fused to HPV-16 E7 Antigen Has Prophylactic and Therapeutic Efficacy in a Cervical Cancer Mouse Model.
Cancers (Basel). 2019 Jan 15;11(1):96.