Margaret J. Lange, PhD


Viruses cause debilitating and life-threatening infections, as well as a variety of human cancers. They also reveal the beauty of biology and illuminate the delicate balance that exists at the interface of pathogenesis and immunity. Host and viral factors influence pathogenesis and infection outcomes, and targeting the cellular mechanisms at the host-virus interface represents an innovative therapeutic strategy that is widely applicable to a variety of diseases. Through her work, Dr. Lange hopes to increase understanding of mechanisms at the host-virus interface that dictate biological outcomes, highlighting the molecular tug-of-war between host and virus and the complexity underlying co-evolution.

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Academic Information

Assistant Professor


7 Hospital Dr
Room NW301A Medical Sciences Bldg
Columbia, MO 65201
United States

P. 573-884-5159

Research Interests

  • Innate Immunity
  • Virology
  • Molecular Therapies
  • HIV Biology
  • Host Response to Viral Infection
  • Aptamers
  • Immunomodulation
  • Toll-Like Receptors
  • Cellular Signaling
  • Nucleic Acid-Protein Interactions

Areas of Expertise

  • Cell Biology
  • Gene Expression
  • Gene Therapy
  • Immune Response to Viruses
  • Toll-Like Receptors
  • Cellular Signaling
  • Molecular Biology
  • Molecular Evolution
  • RNA Biology
  • Virology
  • Aptamer Selection Technology
  • Engineering

Education & Training

Post-Graduate School

2008, PhD, University of Missouri

Awards & Honors

  • Ruth L. Kirchstein National Research Service Award - Postdoctoral Fellowship Grant, May 2010