Profile
Viruses cause debilitating and life-threatening infections, as well as a variety of human cancers. They also reveal the beauty of biology and illuminate the delicate balance that exists at the interface of pathogenesis and immunity. Host and viral factors influence pathogenesis and infection outcomes, and targeting the cellular mechanisms at the host-virus interface represents an innovative therapeutic strategy that is widely applicable to a variety of diseases. Through her work, Dr. Lange hopes to increase understanding of mechanisms at the host-virus interface that dictate biological outcomes, highlighting the molecular tug-of-war between host and virus and the complexity underlying co-evolution.
Academic Information
Assistant Professor
Office
7 Hospital Dr
Room NW301A Medical Sciences Bldg
Columbia, MO 65201
United States
P. 573-884-5159
Research Interests
- Innate Immunity
- Virology
- Molecular Therapies
- HIV Biology
- Host Response to Viral Infection
- Aptamers
- Immunomodulation
- Toll-Like Receptors
- Cellular Signaling
- Nucleic Acid-Protein Interactions
Areas of Expertise
- Cell Biology
- Gene Expression
- Gene Therapy
- HIV/AIDS
- Immune Response to Viruses
- Toll-Like Receptors
- Cellular Signaling
- Molecular Biology
- Molecular Evolution
- RNA Biology
- Virology
- Aptamer Selection Technology
- Engineering
Education & Training
Post-Graduate School
2008, PhD, University of Missouri
Awards & Honors
- Ruth L. Kirchstein National Research Service Award - Postdoctoral Fellowship Grant, May 2010
Publications
- Nguyen P, Zheng J, Tuske S, Lange MJ, Griffin PR, Arnold E, and Burke DH. Structural features of inhibitory RNA aptamers shape their interaction with HIV Reverse Transcriptase. 2019. Under revision at Nucleic Acids Research.
- Camargo C, Lange MJ, and DH Burke. Promoter engineering for viral vector-mediated delivery of antiviral RNA genes. 2019. Under review at AIDS Research and Therapy
- Lange MJ* and Johnson MC*. Diphtheria toxin A-resistant cell lines for robust production and evaluation of DTA-encoding lentiviral particles. Scientific Reports. 2019. 9(1):8985. *Corresponding Author(s)
- Singh K, Gallazzi F, Hill KJ, Burke DH, Lange MJ, Quinn TP, Neogi U, and Sönnerborg A. GS-CA compounds: First-In-Class HIV-1 capsid inhibitors covering multiple grounds. Frontiers in Microbiology (Virology). 2019. 10:1227.
- Lange MJ*, Burke DH, Chaput JC. Activation of Innate Immune Responses by a Cytosine-Phosphate-Guanine Oligonucleotide Sequence Composed Entirely of Threose Nucleic Acid. Nucleic Acid Therapeutics. 2019 Feb. 29(1):51-59. PMID: 30526333 *Corresponding author
- Alam KK, Chang JC, Lange MJ, Nguyen PDM, Sawyer AW, Burke DH. Poly Target Selection Identifies Broad Spectrum RNA Aptamers. Molecular Therapy Nucleic Acids. 2018.13:605-619. PMID: PMC6251793
- Porciani D, Cardwell LN, Tawiah KD, Alam KK, Lange MJ, Daniels MA, and Burke DH. A modular cell internalizing aptamer nanostructure enables targeted delivery of large functional RNAs. Nature Communications. 2018. 9:2283. PMID: 29891903
- Lange MJ*, Nguyen PD, Callaway MK, Johnson MC, and Burke DH*. RNA-Protein interactions govern antiviral specificity and encapsidation of broad-spectrum anti-HIV-1 reverse transcriptase aptamers. Nucleic Acids Research. 2017. 45(10):6087-6097. PMID: 28334941. *Corresponding Author(s)
- Lange MJ and DH Burke. Screening inhibitory potential of anti-HIV RT RNA aptamers. Methods in Molecular Biology. 2014. 1103:11-29. PMID 24318883.
- Whatley AS*, Ditzler MA*, Lange MJ*, Biondi E*, Sawyer AW*, Chang J, Bose D, Franken J, and Burke DH. Non-pseudoknot RNA aptamers with expanded breadth of cross-clade inhibition of HIV-1 reverse transcriptase. Molecular Therapy Nucleic Acids. 2013. 2:e71. PMID 24318883. *Co-First Authors
- Ditzler MA, Lange MJ, Bottoms C, Bose D, Virkler K, Sawyer AW, Whatley AS, Spollan W, Givan S, and Burke DH. New aptamers, neutral networks and next-generation sequencing: A fresh look at HIV reverse transcriptase aptamers. Nucleic Acids Research. 2013. 41(3):1873-84. PMID 23241386.
- Lange MJ, Sharma TK, Whatley AS, Landon LA, Tempesta MA, Johnson MC, and Burke DH. Robust suppression of HIV replication by intracellularly expressed reverse transcriptase aptamers is independent of ribozyme processing. Molecular Therapy. 2012. 20(12):2304-14. PMID 22948672.
- Lange MJ and Misfeldt ML. The importance of TLR3 expression and hormonal regulation of TLR3-induced immune responses in the human endometrium. Current Immunology Reviews. 2009. 5(3):215-226.
- Lange MJ, Lassiter JC, Misfeldt ML. Toll-like receptors in tonsillar epithelial cells. International Journal of Pediatric Otorhinolaryngology. 2009. 73(4):613-621. PMID 19167100.
- Lange MJ, Oller AR, Sarkar S. Antimicrobial activity of mono- and di-methyl substituted benzhydrols and benzophenones, in vitro. Transactions of the Missouri Academy of Sciences. 2007. 41:14-19.
- Lesmeister (Lange) MJ, Bothwell MR, Misfeldt ML. Toll-like receptor expression in the human nasopharyngeal tonsil (adenoid) and palantine tonsils: A preliminary report. International Journal of Pediatric Otorhinolaryngology. 2006. 70(6):987-92. PMID 16325925.
- Lesmeister (Lange) MJ, Jorgenson RL, Young SL, Misfeldt ML. 17beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells. Reproductive Biology and Endocrinology. 2005. 3:74. PMID 16384532.
- Jorgenson RL, Lesmeister (Lange) MJ, Young SL, Lyddon TD, Misfeldt ML. Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. Human Immunology. 2005. 66(4):469-482. PMID 15935884.
- Lange MJ, Sarkar S, Oller AR. Synthesis and investigation of antibacterial activity of model compounds derived from dapsone. McNair Central Achievers Program (McCAP) Journal. 2002.