Profile
The McIntosh laboratory is studying the processes and regulation of iron assimilationin bacteria. Microbes secrete iron chelating molecules (siderophores) to solubilize iron for metabolic needs. The biosynthesis and transport of siderophores are regulated at the molecular level by intracellular iron concentrations. Using the Escherichia coli siderophore enterobactin as a model, we are investigating a complex gene system (ent-biosynthesis; fep-transport; fes-iron removal), composed of six separate transcripts emanating from three tightly iron-controlled bidirectional promoter/operator regions.
Academic Information
Research Director, Ellis Fischel Cancer Center
Vice President, Research and Economic Development, UM System
Vice Chancellor, Research, Graduate Studies and Economic Development, MU
Professor
Office
M616 Medical Sciences Building
Columbia, MO 65212
United States
P. 573-882-8989
Research Interests
- Bacterial Genetics and Bacterial Pathogenesis
- Gene Expression
- Signal Transduction
- Bacteriology
Areas of Expertise
- Iron-mediated regulation of gene expresssion
- Bacterial membrane transport processes using energy-driven receptors
- Molecular biology of mycoplasmas
Education & Training
Post-Graduate School
1978, PhD, University of Texas at Austin
Publications
- Calcutt MJ, Foecking MF, Heidari MB, and MA McIntosh. 2015. Complete Genome Sequence of Mycoplasma flocculare Strain Ms42T (ATCC 27399T). Genome Announc. 2015 Mar 12;3(2). pii: e00124-15. doi: 10.1128/genomeA.00124-15. PMID: 25767245
- McGreevy JW, Hakim CH, McIntosh MA, and D Duan. 2015. Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy. Dis Model Mech. 2015 Mar;8(3):195-213. doi: 10.1242/dmm.018424. Review. PMID: 25740330
- Ericsson AC, Davis JW, Spollen W, Bivens N, Givan S, Hagan CE, McIntosh M, and CL Franklin. 2015. Effects of Vendor and Genetic Background on the Composition of the Fecal Microbiota of Inbred Mice. PLoS One. Feb 12;10(2):e0116704. doi: 10.1371/journal.pone.0116704. eCollection 2015. PMID: 25675094
- Kodippili K, Vince L, Shin JH, Yue Y, Morris GE, McIntosh MA, and D Duan. 2014. Characterization of 65 epitope-specific dystrophin monoclonal antibodies in canine and murine models of duchenne muscular dystrophy by immunostaining and western blot. PLoS One. 2014 Feb 7;9(2):e88280. doi: 10.1371/journal.pone.0088280. eCollection 2014. PMID: 24516626
- Rai DK, Schafer EA, Singh K, McIntosh MA, Sarafianos SG, and E Rieder. 2013. Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of foot-and-mouth disease virus in host cells. Antiviral Res. 2013 Jun;98(3):380-5. doi: 10.1016/j.antiviral.2013.03.022. Epub 2013 Apr 8. PMID: 23578728