Mark McIntosh, PhD

Mark McIntosh, PhD

Molecular Microbiology and Immunology

Professor
Vice President, Research and Economic Development, UM System
Vice Chancellor, Research, Graduate Studies and Economic Development, MU

573-882-8989

Profile

The McIntosh laboratory is studying the processes and regulation of iron assimilationin bacteria. Microbes secrete iron chelating molecules (siderophores) to solubilize iron for metabolic needs. The biosynthesis and transport of siderophores are regulated at the molecular level by intracellular iron concentrations. Using the Escherichia coli siderophore enterobactin as a model, we are investigating a complex gene system (ent-biosynthesis; fep-transport; fes-iron removal), composed of six separate transcripts emanating from three tightly iron-controlled bidirectional promoter/operator regions.

Academic Information

Professor
Vice President, Research and Economic Development, UM System
Vice Chancellor, Research, Graduate Studies and Economic Development, MU

Office

M616 Medical Sciences Building
Columbia, MO 65212
United States

P. 573-882-8989

Research Interests

  • Bacterial Genetics and Bacterial Pathogenesis
  • Gene Expression
  • Signal Transduction
  • Bacteriology

Areas of Expertise

  • Iron-mediated regulation of gene expresssion
  • Bacterial membrane transport processes using energy-driven receptors
  • Molecular biology of mycoplasmas

Education & Training

Post-Graduate School

1978, PhD, University of Texas at Austin

Publications