Michael Misfeldt, PhD

Photo of Michael Misfeldt, PhD

Molecular Microbiology and Immunology

Professor
Senior Associate Dean for Faculty Affairs

573-882-8152

Profile

Toll-like receptors (TLRs), a family of pattern recognition receptors of the innate immune system, have emerged as key upstream mediators of inflammation. Ligation of TLRs results in the production of cytokines, chemokines, antimicrobial molecules, and other immunomodulatory molecules that impact host responses. Our laboratory has shown that the TLR3 receptor, which recognizes double stranded RNA (dsRNA), is expressed and functional in the human endometrium. We have also shown that the expression of TLR3 in the human endometrium is cyclically regulated and the production of cytokines and chemokines uponTLR3 ligation could be regulated by the endometrial steroid hormones, E2 and P. Thus, the focus of the laboratory is to gain a better understanding of TLR3 signaling, TLR3 function, and the impact of steroid hormones on TLR3-driven responses in the human endometrium.

Academic Information

Professor
Senior Associate Dean for Faculty Affairs

Office

M616 Medical Sciences Building
Columbia, MO 65212
United States

P. 573-882-8152

Research Interests

  • Immune Response to Pathogens
  • Innate Immunity
  • Inflammation
  • Immunology

Areas of Expertise

  • Innate immunity
  • Toll-like receptors (TLRs)

Education & Training

Post-Graduate School

1977, PhD, University of Iowa

Publications

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