Nicholas Madaffer, DO

Nicholas Madaffer

Physical Medicine and Rehabilitation

Adjunct Assistant Professor of Clinical PM&R

Academic Information

Adjunct Assistant Professor of Clinical PM&R


1 Hospital Drive
Columbia, MO 65212
United States

Research Interests

  • Spinal cord neuromodulation
  • Regenerative orthopaedic/orthobiologic medicine
  • Interventional pain medicine
  • Comprehensive spine care outcomes

Areas of Expertise

  • Comprehensive interventional pain medicine and non-operative spine medicine and rehabilitation
  • Genicular (knee pain) nerve blocks/radio-frequency ablation
  • Epidural steroid injections in cervical, thoracic, lumbar, sacral and caudal areas
  • Facet joint intra-articular injections
  • Facet joint medial branch nerve Blocks/radio-frequency ablation
  • Third occipital nerve blocks/radio-frequency ablation
  • Sacroiliac joint injections
  • Major joint intra-articular injections of steroids or hyaluronic acid: knee, hip and shoulder
  • Sympathetic and visceral mediated pain interventions: stellate ganglion, lumbar hypogastric plexus, lumbar sympathetic ganglion and ganglion impar nerve blocks
  • Paravertebral nerve blocks for pleural, post-thoracotomy, post-mastectomy or post-herpetic neuralgia pain
  • Botox injections for muscle spasticity including: migraines, cervical dystonia and piriformis muscle syndrome
  • Trigger point injections for myofascial pain and spasms
  • Spinal cord stimulator trials
  • Kyphoplasty/vertebroplasty

Education & Training

Medical School

University of New England College of Osteopathic M


Berkshire Medical Center Hospital


University of Wisconsin Medical School


Louisiana State University at New Orleans School o

Board Certification

American Board of Physical Medicine and Rehab
American Board of PMR - Pain Mgmt

Awards & Honors

  • 2013 American Osteopathic Association Historical Essay Contest, second place
  • 2011 University of New England College of Osteopathic Medicine John Russell Scholarship
  • 2009 Pettapiece Research Fellow - University of New England College of Osteopathic Medicine Competitive Research Grant


  • “Interventional Pain Management: Nerve Blocks and Neurolysis.” Nicholas C. Madaffer DO, Harry J Gould III MD PhD, & Alan Kaye MD PhD. Academic Pain Medicine: A Practical Guide to Rotations, Fellowship, and Beyond, edited by Yury Khelemsky, Karina Gritsenko, and Anuj Malhotra, Springer Press, in press.
  • Mechanical Changes of the Brain During Sleep Clear Metabolites and Provide Key Mechanism for Sutherland's Cranial Respiratory Impulse.” Nicholas C. Madaffer, DO & Hollis H. King, DO, PhD; J Am Osteopath Assoc May 2014 114:407-408; doi:10.7556/jaoa.2014.084