Profile
Dr. Sharad Khare’s research is focused on both basic science and clinical oncology research. He works with Truman VA Hospital and is involved in research programs funded by the National Cancer Institute.
Academic Information
Director of Gastrointestinal Cancer Research
Professor of Medicine
VA Research Health Scientist
P. 573-882-1013
Research Interests
- Cancer Informatics
- Clinical research with colorectal cancer
- Colorectal cancer metastasis
- Drug delivery
- Epigenetics
- Hepatocellular carcinoma
- Inflammatory bowel disease
- Inflammatory bowel disease and kidney patients
- Nano and glass particle in wound healing
Areas of Expertise
- Cre/loxP technology
- CRISPR/Cas9 Technology
- In Vitro and in vivo molecular research models
- Genetic and sporadic colorectal cancer and hepatocellular carcinoma mouse model research
- MicroRNA research
Education & Training
Post-Graduate School
University of Kanpur, Kanpur, India
Awards & Honors
FEDERAL GRANT AWARDS:
- 2008-2011 VA Merit Award (PI)
- 2011-2016 VA Merit Award (PI)
- 2017-2021 VA Merit Award (PI)
- 2002-2005 NIH/NCI RO3 Award (PI)
- 2003-2009 NIH/NCI RO1 Award (Co-Investigator)
- 2011-2013 NIH/NCI RO3 Award (PI)
- 2017-2019 NIH/NCI RO3 Award (PI)
SOCIETY MEMBERSHIPS:
- 2003- American Gastroenterological Association
PROFESSIONAL INTRAMURAL COMMITTEES:
- Fellowship Program Interviews, Section of Gastroenterology And Hepatology, Department of Medicine, University of Missouri, MO
- Subcommittee of Research Safety (SRS), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, MO
- Subcommittee of Animal Studies (SAS), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, MO
- Research and Development Committee (R&D), United States Department of Veterans Affairs, Harry S. Truman Memorial Veterans’ Hospital, MO
- Research Mentoring Committee of Division of Gastroenterology, University of Missouri, MO
- Internal Medicine Research Council, University of Missouri-Columbia, MO
- School of Medicine Research Council, University of Missouri-Columbia, MO
- Subcommittee of Animal Studies (SAS), United States Department of Veterans Affairs, Hines Medical Center, IL
- Subcommittee of Animal Studies (SAS), Loyola University Medical Center, IL
RESEARCH GRANT REVIEWER:
Extramural (Federal):
- Ad Hoc Member Cancer Prevention Study Section, National Institute of Health (National Cancer Institute)
- Ad Hoc Member Department of Veterans Affairs (VA Merit, BLR&D Program)
- Ad Hoc Member VA (BLR&D) Oncology Study Section
- Ad Hoc Member Department of Defense (CDMRP Program of Stomach Cancer)
INVITED PRESENTATIONS IN INTERNATIONAL CONFERENCES:
- Speaker and Chair on Medical Oncology at Global Cancer Summit organized by governments of United Kingdom and India
- Frontiers in Cancer Science, Singapore
- International Conference on “Herbal and Synthetic Drugs” India
- Global Summit on Oncology and Cancer, Osaka, Japan
Publications
PEER REVIEWED JOURNAL PUBLICATIONS:
- Qiong Zhang, Tao Wei, Kan Xu, Kevin Wright, Alexander Jurkevich, Katherine Shim and Sharad Khare. Atypical role of Sprouty2 in colorectal cancer: Sprouty repression inhibits epithelial-mesenchymal transition. Oncogene, 35 (24); 3151-62, 2016 (Impact Factor-8.7) (Rank # 5 out of 194 cancer research journals)
- Qiong Zhang, Katherine Shim, Kevin Wright, Alexander Jurkevich and Sharad Khare Atypical role of Sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer, Molecular Carcinogenesis, 55(9); 1355-68, 2016 (Impact Factor-4.8) (Rank # 51 out of 194 cancer research journals)
- Vivek Vaish, Tripti Khare, Mukesh Verma and Sharad Khare Epigenetic therapy for colorectal cancer Methods in Molecular Biology (Cancer Epigenetics) Vol. 1238, DOI 10.1007/978-1-4939-1804-1_40, 2015 (Impact Factor-1.3) (Rank # 23 out of 214 biochemistry, genetics and molecular biology miscellaneous journals)
- Urszula Dougherty, Reba Mustafi, Farhana Sadiq, Anas Almoghrabi, Devkumar Mustafi, Maggi Kreisheh, Sumana Sundaramurthy, Weicheng Liu, Vani J Konda, Joel Pekow, Sharad Khare, John Hart, Loren Joseph, alice Wyrwicz, Gregory S. Karczmar, Yan Chun Li and Marc Bissonnette. The renin-angiotensin system mediates epidermal growth factor receptor-vitamin D receptor cross-talk in colitis-associated colon cancer Clinical Cancer Research, 20 (22); 5848-5859, 2014. (Impact Factor-8.2) (Rank # 6 out of cancer research 194 journals)
- Tripti Khare and Sharad Khare Controversies in chemoprevention of colorectal cancer with ursodeoxycholic acid JSM Gastroenterology and Hepatology, 2 (1); 1-4, 2014 (An Online Research Communication)
- Sharad Khare, Qiong Zhang and Jamal A Ibdah, Epigenetics of hepatocellular carcinoma: Role of microRNA. World Journal of Gastroenterology 19 (33): 5439–5445, 2013. (Impact Factor-2.5) (Rank # 13 out of 132 gastroenterology journals)
- Qiong Zhang, Mukesh Verma and Sharad Khare Epigenetic regulation of microRNA in colon cancer Epigenetics and Cancer DOI 10.1007/978-94-007-6612-9_5, 2013 (Book Chapter)