Tadashi Yoshida, PhD

Academic Information

Assistant Professor

Office

1 Hospital Drive
Columbia, MO 65212
United States

P. 573-884-0825

Research Interests

  • Skeletal muscle wasting
  • Cachexia
  • Congestive heart failure

Areas of Expertise

  • Skeletal muscle physiology
  • Cardiovascular disease
  • Molecular biology
  • Molecular genetics
  • Cell biology

Education & Training

Fellowship

2007, Tulane University

Post-Graduate School

2006, PhD in Biological Science, The University of Tokyo, Japan

Awards & Honors

  • 2017: Research Council Award, University of Missouri
  • 2015: Department of Medicine R&D funding, University of Missouri
  • 2015: Scientist Development Grant, American Heart Association
  • 2013: Pilot Project Award, Mentoring Research Excellence in Aging and Regenerative Medicine, Tulane University
  • 2013, 2014: SAFMR/SSCI Research Award, American Federation for Medical Research and Southern Society for Clinical Investigation

Publications

  • Yoshida T, Delafontaine P. An intronic enhancer element regulates angiotensin II type 2 receptor expression during satellite cell differentiation and its activity is suppressed in congestive heart failure. J Biol Chem 2016 Dec 2;291(49):25578-90.
  • Yoshida T, Delafontaine P. Mechanisms of Cachexia in Chronic Disease States. Am J Med Sci. 2015 Jun 16;:1.
  • Yoshida T, Huq TS, Delafontaine P. Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration. J Biol Chem. 2014 Sep 19;289(38):26239–48.
  • Yoshida T, Friehs I, Mummidi S, Del Nido PJ, Addulnour-Nakhoul S, Delafontaine P, Valente AJ, Chandrasekar B. Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death. J Mol Cell Cardiol. 2014 Aug 7;75C:141–51.
  • Yoshida T, Galvez S, Tiwari S, Rezk BM, Semprun-Prieto L, Higashi Y, Sukhanov S, Yablonka-Reuveni Z, Delafontaine P. Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration. J Biol Chem. 2013 Aug 16;288(33):23823–32. PMCID: PMC3745329
  • Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S, Delafontaine P. Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: Potential therapeutic targets for cardiac cachexia. Int J Biochem Cell Biol. 2013 Oct;45(10):2322–32. PMCID: PMC3759646
  • Yoshida T, Semprun-Prieto L, Wainford RD, Sukhanov S, Kapusta DR, Delafontaine P. Angiotensin II reduces food intake by altering orexigenic neuropeptide expression in the mouse hypothalamus. Endocrinology. 2012 Mar;153(3):1411–20. PMCID: PMC3281527
  • Yoshida T, Semprun-Prieto L, Sukhanov S, Delafontaine P. IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1565–70. PMCID: PMC2867436

View Yoshida's full list of publications