Profile
The Subramanian Lab’s research is dedicated to identifying efficient therapeutic targets for the complex life-threatening sexually dimorphic aortic vascular disease - abdominal aortic aneurysms (AAA). AAA is an asymptomatic permanent dilation of abdominal aorta which often cause death by aortic rupture in patients. The current available therapy is restricted to surgical repair, highlighting the need to explore mechanistic insights into AAA to develop effective, non-surgical therapeutics. To fulfill this goal, the primary focus of our lab research is to study the functional contribution of cytoskeletal structural proteins, smooth muscle cell homeostasis and extracellular matrix protein stability to aortic structural wall integrity during AAA development.
Academic Information
Office
1 Hospital Drive
Medical Sciences Building, NW301B
Columbia, MO 65212
United States
Research Interests
- Aortic Vascular Disease
- Abdominal Aortic Aneurysms
- Thoracic Aortic Aneurysms
- Atherosclerosis
- Obesity
Areas of Expertise
- Aortic Aneurysms
- Smooth Muscle Cell Homeostasis
- Autophagy
- Extracellular Matrix Protein Stability
Education & Training
Degrees
2003 PhD, Annamalai University, India
Fellowship
2006 - 2010 University of Kentucky, Lexington, KY
2003 - 2006 East Tennessee State University, Johnson City, TN
Awards & Honors
- 2000-2003: Indian Council of Medical Research Foundation Predoctoral Fellowship
- 2008-2010: American Heart Association Postdoctoral Fellowship Award (Great Rivers Affiliate), AHA Identification No: 0825592D
- 2009: New Investigator Travel Award, Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) Council of the American Heart Association - ATVB Annual Scientific Meeting (Spring Session)
- 2009: Best Poster Presentation Award, 12th Annual Gill Heart Institute Cardiovascular Research Day, University of Kentucky
- 2009: New Investigator Travel Award, ATVB Council of the American Heart Association - (Fall Session)
- 2011-2012: Pilot Grant Award from the Center of Research in Obesity and Cardiovascular Disease (COCVD), University of Kentucky
- 2013-2014: American Heart Association Beginning Grant-in-Aid Award (Great Rivers Affiliate), AHA Identification No: 13BGIA14560001
- 2013: Outstanding Research Presentation Award at Barnstable Brown Obesity and Diabetes Research Day, University of Kentucky
- 2013-2014: Pilot and Feasibility Grant Award from Washington University Diabetes Research Center
- 2014-2015: Early Investigator Research Grant from The National Marfan Foundation
- 2014-2017: American Heart Association Scientist Development Grant (National Center) AHA Identification No: 14SDG18740000
- 2015-2019: Junior Investigator, Center of Research in Obesity and Cardiovascular Disease (COCVD) from NIH P20GM103527
- 2020-Present: Fellow of the American Heart Association (FAHA), ATVB Council.
- 2018, 2019, 2020, 2021 & 2022: Charles T. Wethington Excellence in Research Award University of Kentucky.
Publications
- Muniappan L, Javidan A, Thiagarajan D, Jiang W, Moorleghen JJ, Uchida HA, Takano, J, Saido TC, Subramanian V*.
Inducible Depletion of Calpain-2 Attenuates Angiotensin II-induced Cytoskeletal Structural Protein Destruction during Abdominal Aortic Aneurysm Development in Mice.
Arterioscler Thromb Vasc Biol 2021 41: 1694-1709. (PMID:33761765). - Okuyama M, Jiang W, Yang L, Subramanian V*.
MST1/2 Kinases Inhibitor, XMU-MP-1 Attenuates AngII-induced Ascending Aortic Expansion in Hypercholesterolemic Mice.
Circ Rep 2021 20: 259-266. (PMID: 34007939). - Okuyama M, Jiang W, Javidan A, Chen JZ, Howatt DA, Yang L, Yamaguchi M, Yasugi T, Aono J, Vazquez-Padron, RI, Subramanian V.
Lysyl Oxidase Inhibition Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice.
Circulation 2020 142: 1993-1995. (PMID:33196308) - Javidan A, Jiang W, Okuyama M, Thiagarajan D, Yang L, Moorleghen JJ, Muniappan L, Subramanian V.
miR-146a Deficiency Accelerates Hepatic Inflammation Without Influencing Diet-induced Obesity in Mice. Scientific Reports 2019 9:12626. (PMID: 31477775)