Vincent G. DeMarco, PhD

DeMarco

Medicine

Associate Research Professor

573-814-6000

Academic Information

Associate Research Professor
P. 573-814-6000

Areas of Expertise

  • Mechanisms of cardiac dysfunction
  • Obesity associated vascular stiffness
  • Cardiovascular phenotyping

Education & Training

Post-Graduate School

University of Florida, Gainesville, Florida; Texas Christian University, Fort Worth, Texas

Publications

  • Aroor AR, Sowers JR, Bender SJ, Nistala N, Garro M, Mugerfeld I, Hayden MR, Johnson MS, Salam S, Whaley-Connell A, DeMarco VG. Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male Zucker obese rats.Endocrinology, 2013; 154:2501-2513. PMID: 23653460
  • Aroor AR, Jia G, Sowers JR, DeMarco VG. Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors in the vasculature. Am J Physiol Heart&Circ Physiol 307:H477- H492. PMID: 24929856
  • Manrique C, Habibi J, Aroor AR, Sowers JR, Jia G, Hayden MR, Garro M, Martinez-Lemus LA, Ramirez-Perez FI, Klein T, Meininger GA, DeMarco VG 2016 Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice. Cardiovasc Diabetol 15:94 PMID: 27391040
  • Habibi J, Aroor AR, Sowers JR, Jia G, Hayden MR, Garro M, Barron B, Mayoux E, Rector SR, Whaley-Connell A, DeMarco, VG. 2017; Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes. Cardiovasc Diabetol, 13:9. PMID: 28086951
  • Erickson JM, Valente AJ, Hemanthkumar K, Raikwar SP, DeMarco VG, Bender SB, Fay WP, Siebenlist U, Chandrasekar B. Targeting traf3ip2 by genetic and interventional approaches inhibits ischemia/reperfusion-induced myocardial injury. J Biol Chem. 2017; jbc.M116.764522. doi: 10.1074/jbc.M116.764522.
  • Aroor AR, Habibi J, Hemanthkumar K, Garro M, Barron B, Hayden MR, Jia G, Whaley-Connell A, Klein T, Sowers JR, Chandrasekar B, and DeMarco VG. Dipeptidyl Peptidase-4 (DPP-4) inhibition with linagliptin reduces the induction of proinflammatory/profibrotic TRAF3IP2 in the hearts of female mice fed a Western Diet. Am J Physiol, Heart and Circ. (in review).
  • Padilla J, Ramirez-Perez FI, Habibi J, Bostick B, Aroor AR, Hayden MR, Jia G, Garro M, DeMarco VG, Manrique C, Booth FW, Martinez-Lemus LA, Sowers JR. Regular exercise reduces endothelial cortical stiffness in western diet-fed female mice. Hypertension. 2016;68:1236-1244. PMID:27572153
  • DeMarco VG, Johnson MS, Ma L, Pulakat L, Mugerfeld I, Hayden MR, Garro M, Knight W, Britton SL, Koch LG and Sowers JR. Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2012; 302:H1667-82. PMID: 22345570
  • Johnson MS, DeMarco VG, Heesch CM, Whaley-Connell AT, Schneider RI, Rehmer NT, Tilmon RD, Ferrario CM, Sowers JR. Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1540-50. PMID: 21821781
  • Manrique C, DeMarco VG, Aroor A, Mugerfeld I, Garro M, Habibi J, Hayden MR, Sowers JR. Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a western diet. Endocrinology, 2013; 154:3632-42. PMID: 23885014
  • DeMarco VG, Habibi J, Jia G, Annayya A R, Ramirez F, Martinez-Lemus L, Bender SB, Garro M, Hayden MR, Sun Z, Meininger GA, Manrique C, Whaley-Connell A, and Sowers JR. Low dose mineralocorticoid receptor blockade prevents arterial stiffening in Western Diet-fed female mice, Hypertension, 2015 66: 99-107. PMID: 26015449
  • Bostick B, Habibi J, DeMarco VG, Jia G, Domeier TL, Lambert MD, Aroor AR, Nistala R, Bender SB, Garro M, Hayden MR, Ma L, Manrique Acevedo C, Sowers JR. Mineralocorticoid Receptor Blockade Prevents Western Diet-induced Diastolic Dysfunction in Female Mice. Am J Physiol Heart Circ Physiol. 2015 308: H1126-35. PMID: 25747754
  • Bender SB, DeMarco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR. Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction. Hypertension. 2015 65:1082-8. PMID: 25712719
  • DeMarco VG, Habibi J, Jia G, Annayya A R, Ramirez F, Martinez-Lemus L, Bender SB, Garro M, Hayden MR, Sun Z, Meininger GA, Manrique C, Whaley-Connell A, and Sowers JR. Low dose mineralocorticoid receptor blockade prevents arterial stiffening in Western Diet-fed female mice. Hypertension. 2015 66: 99-107. PMID: 26015449
  • Jia G, Habibi J, DeMarco VG, Martinez-Lemus LA, Ma L, Whaley-Connell AT, Aroor AR, Domeier TL, Zhu Y, Meininger GA, Mueller KB, Jaffe IZ, Sowers JR. Endothelial mineralocorticoid receptor deletion prevents diet-induced cardiac diastolic dysfunction in females. Hypertension. 2015;66:1159-1167. PMID: 26441470