Yusuke Higashi, PhD

Profile

Atherosclerosis is the cause of heart diseases, stroke and peripheral artery diseases, which are the leading cause of mortality in the USA. The pathogenesis of atherosclerosis is a highly complicated process, including oxidative stress, inflammation, dysregulation of cell structure and function, and cell death. My research focus is on hormonal/growth factors' regulation of vascular cells and inflammatory cells that are involved in atherosclerosis, with an emphasis on translation of findings on a bench to a bedside.

Academic Information

Assistant Research Professor

Office

One Hospital Drive
Columbia, MO 65212
United States

P. 573-884-0371

Research Interests

  • Atherosclerosis
  • Vascular inflammation
  • Vascular endothelial function

Areas of Expertise

  • Cell biology
  • Molecular biology
  • Oxidative stress
  • Hormone/Growth factors
  • Vascular disease model

Education & Training

Post-Graduate School

1996, PhD, University of Tokyo

Awards & Honors

  • SAFMR/SSCI Young Faculty Research Travel Award, American Federation for Medical Research, at 2010 Southern Regional Meeting. February 2013 (New Orleans, LA, U.S.A.)
  • SAFMR/SSCI Young Faculty Research Award, American Federation for Medical Research, at 2011 Southern Regional Meeting. February 2011 (New Orleans, LA, U.S.A.)
  • SAFMR/SSCI Young Faculty Award, American Federation for Medical Research, at 2010 Southern Regional Meeting. February 2010 (New Orleans, LA, U.S.A.)
  • Chair’s Fund Scholarship, Gordon Research Conferences Meeting for Insulin-Like Growth Factors in Physiology & Disease. March 2009 (Ventura, CA, U.S.A.)
  • SAFMR/SSCI Young Faculty Award, American Federation for Medical Research, at 2008 Southern Regional Meeting. February 2008 (New Orleans, LA, U.S.A.)
  • SAFMR/SSCI Faculty Research Award, American Federation for Medical Research, at 2007 Southern Regional Meeting. February 2007 (New Orleans, LA, U.S.A.)

Publications

  • Higashi Y, Sukhanov S, Shai SY, Danchuk S, Tang R, Snarski P, Li Z, Lobelle-Rich P, Wang M, Wang D, Yu H, Korthuis R, Delafontaine (2016) Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E-Deficient Mice. Circulation, 133: 2263-2278
  • Somanna, NK, Valente AJ, Krenz M, McDonald KS, Higashi Y, Noda M, Chandrasekar B. (2016) Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation. Hypertension Res., 39: 709-716.
  • Sakamuri SS, Higashi Y, Sukhanov S, Siddesha JM, Delafontaine P, Siebenlist U, Chandrasekar B. (2016) TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE-/- mice. Atherosclerosis, 252: 153-160.
  • Sukhanov S, Snarski P, Vaughn C, Lobelle-Rich P, Kim C, Higashi Y, Shai SY, Delafontaine P. (2015) Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase. Atherosclerosis, 238: 313-320
  • Blackstock CD, Higashi Y, Sukhanov S, Shai SY, Stefanovic B, Tabony AM, Yoshida T, Delafontaine P. (2014) Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5' stem-loop of COL1a1 and COL1a2 mRNA. J Biol Chem., 289: 7264-7274
  • Yoshida T, Galvez S, Tiwari S, Rezk BM, Semprun-Prieto L, Higashi Y, Sukhanov S, Yablonka-Reuveni Z, Delafontaine P. (2013) Angiotensin II Inhibits Satellite Cell Proliferation and Prevents Skeletal Muscle Regeneration. J Biol Chem., 288: 23823-23832.
  • Higashi Y, Pandey A, Goodwin B, Delafontaine P. (2013) Insulin-like growth factor-1 regulates glutathione peroxidase expression and activity in vascular endothelial cells: Implications for atheroprotective actions of insulin-like growth factor-1. Biochim Biophys Acta., 1832: 391-399.