Andrew Kelleher, PhD

Andrew Kelleher, PhD

Obstetrics, Gynecology and Women's Health

Assistant Professor
NextGen Precision Health Investigator


Dr. Kelleher's long-term research goal is to define the critical physiological and genetic pathways that regulate uterine development, function, and regeneration to diagnose, treat, and prevent infertility and disease in women. To this end, his research utilizes mouse genetic models, endometrial organoid culture (human and mouse), and next-generation sequencing methods to comprehensively determine physiological and molecular aspects of uterine function and disease.

Academic Information

Assistant Professor
NextGen Precision Health Investigator


1030 Hitt Street
Roy Blunt NextGen Precision Health Building
Columbia, MO 65212
United States

Research Interests

  • Reproductive and Developmental Biology
  • Mechanisms governing endometrial diseases

Areas of Expertise

  • Uterine Development and Disease
  • Embryo Implantation
  • Endometrial Decidualization


Education & Training


2013 BS, Cornell University
2018 PhD, University of Missouri
2018-2021 Fellowship, UT Southwestern Medical Center

In the News


  • Dickson MJ, Oh Y, Gruzdev A, Li R, Balaguer N, Kelleher AM, Spencer TE, Wu SP, DeMayo FJ.
    Inserting Cre recombinase into the Prolactin 8a2 gene for decidua-specific recombination in mice.
    Genesis. 2022 May;60(4-5):e23473. doi: 10.1002/dvg.23473. Epub 2022 Apr 27. PubMed PMID: 35475540.
  • Kelleher AM, Setlem R, Dantzer F, DeMayo FJ, Lydon JP, Kraus WL.
    Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.
    Proc Natl Acad Sci U S A. 2021 Oct 5;118(40). doi: 10.1073/pnas.2109252118. PubMed PMID: 34580230; PubMed Central PMCID: PMC8501838.
  • Dhakal P, Fitzgerald HC, Kelleher AM, Liu H, Spencer TE.
    Uterine glands impact embryo survival and stromal cell decidualization in mice.
    FASEB J. 2021 Oct;35(10):e21938. doi: 10.1096/fj.202101170RR. PubMed PMID: 34547143.
  • Dhakal P, Kelleher AM, Behura SK, Spencer TE.
    Sexually dimorphic effects of forkhead box a2 (FOXA2) and uterine glands on decidualization and fetoplacental development.
    Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23952-23959. doi: 10.1073/pnas.2014272117. Epub 2020 Sep 8. PubMed PMID: 32900950; PubMed Central PMCID: PMC7519319.
  • Behura SK, Kelleher AM, Spencer TE.
    Regulation of uterine genes during the peri-implantation period, and its relationship to the maternal brain in gestating mice.
    Mol Reprod Dev. 2020 Apr;87(4):482-492. doi: 10.1002/mrd.23338. Epub 2020 Mar 22. PubMed PMID: 32202015; PubMed Central PMCID: PMC9093058.
  • Vasquez YM, Nandu TS, Kelleher AM, Ramos EI, Gadad SS, Kraus WL.
    Genome-wide analysis and functional prediction of the estrogen-regulated transcriptional response in the mouse uterus†.
    Biol Reprod. 2020 Feb 14;102(2):327-338. doi: 10.1093/biolre/ioz183. PubMed PMID: 31511857; PubMed Central PMCID: PMC7016285.
  • Behura SK, Dhakal P, Kelleher AM, Balboula A, Patterson A, Spencer TE.
    The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy.
    Pharmacol Res. 2019 Nov;149:104468. doi: 10.1016/j.phrs.2019.104468. Epub 2019 Oct 7. Review. PubMed PMID: 31600597; PubMed Central PMCID: PMC6944055.
  • Kelleher AM, DeMayo FJ, Spencer TE.
    Uterine Glands: Developmental Biology and Functional Roles in Pregnancy.
    Endocr Rev. 2019 Oct 1;40(5):1424-1445. doi: 10.1210/er.2018-00281. Review. PubMed PMID: 31074826; PubMed Central PMCID: PMC6749889.
  • Kelleher AM, Behura SK, Burns GW, Young SL, DeMayo FJ, Spencer TE.
    Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.
    FASEB J. 2019 Jul;33(7):8543-8554. doi: 10.1096/fj.201900013R. Epub 2019 Apr 5. PubMed PMID: 30951376; PubMed Central PMCID: PMC6593875.
  • Kelleher AM, Milano-Foster J, Behura SK, Spencer TE.
    Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success.
    Nat Commun. 2018 Jun 22;9(1):2435. doi: 10.1038/s41467-018-04848-8. PubMed PMID: 29934619; PubMed Central PMCID: PMC6015089.
  • Kelleher AM, Peng W, Pru JK, Pru CA, DeMayo FJ, Spencer TE.
    Forkhead box a2 (FOXA2) is essential for uterine function and fertility.
    Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1018-E1026. doi: 10.1073/pnas.1618433114. Epub 2017 Jan 3. PubMed PMID: 28049832; PubMed Central PMCID: PMC5307455.

Complete List of publications