Brett Froeliger, PhD

Brett Froeliger, PhD


Director, Cognitive Neuroscience Systems (CNS) Core Facility



Since 2012, Dr. Brett Froeliger’s program of research has been continuously funded by the NIH. It is organized around using fMRI to evaluate the potential benefit of novel pharmacotherapies, behavioral interventions and non-invasive neural stimulation for treating substance-use disorder pathophysiology. He has published over 60 peer-reviewed manuscripts, book chapters and reviews articles. He is the Associate Editor for Nicotine & Tobacco Research, Frontiers in Psychiatry and Evidence-Based Complementary and Alternative Medicine. Dr. Froeliger is dedicated to educating the next generation of addiction scientists, serving as a mentor on multiple NIH career development and fellowship awards.

Academic Information

Director, Cognitive Neuroscience Systems (CNS) Core Facility


111 McAlester Hall
Columbia, MO 65201
United States

P. 573-882-4785

Research Interests

  • Neuroscience
  • Addiction
  • Emotion
  • Cognition

Areas of Expertise

  • Neuropsychopharmacology
  • Brain Imaging
  • Translational research
  • Clinical Trials
  • Laboratory research

Education & Training


2008 - 2011 Duke University Medical Center

Post-Graduate School

2008 PhD, Southern Illinois University Year

In the News


  • Halbert CH, Jefferson MS, Danielson C, Froeliger, B, Giordanoa A, Thaxton J. (in press). An observational study and randomized trial of stress reactivity in cancer disparities. Health Psychology.
  • Hudak, J., Prince, K., Marchand, W., Nakamura, Y., Hanley, A., Bryan, C., Froeliger, B., Garland, E.L. (in press). The Temporal Dynamics of Emotion Dysregulation in Prescription Opioid Misuse. Progress in Neuropsychopharmacology & Biological Psychiatry.
  • McConnell, P. A., E. L. Garland, J. K. Zubieta, R. Newman-Norlund, S. Powers and Froeliger, B. (2020). "Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect." Addict Biol. PMID: 30945801
  • Newman-Norlund, R., Gibson, M., McConnell, P., Froeliger, B. (2020). Dissociable effects of theta-burst repeated transcranial magnetic stimulation to the inferior frontal gyrus on inhibitory control in nicotine addiction. Frontiers in Psychiatry. Apr 15;11:260. PMID: 32351412
  • Garland, E.L., Atchley, R., Howard, M., Zubieta, J-K., Froeliger, B. (2019). Mindfulness-Oriented Recovery Enhancement Restructures Reward Processing Among Chronic Opioid Users: Neurophysiological and Affective Evidence. Science Advances 5(10). PMID 31663023
  • Garland, E. L., M. A. Bryan, S. E. Priddy, M. R. Riquino, Froeliger, B., and M. O. Howard (2019). "Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study." Ann Behav Med 53(10): 865-876. PMID: 30668631
  • Garland, E. L., A. W. Hanley, M. R. Riquino, S. E. Reese, A. K. Baker, K. Salas, B. P. Yack, C. E. Bedford, M. A. Bryan, R. Atchley, Y. Nakamura, Froeliger, B., and M. O. Howard (2019). "Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: A randomized controlled trial." J Consult Clin Psychol 87(10): 927-940. PMID: 31556669
  • Mathew, A. R., B. W. Heckman, B. Froeliger, M. E. Saladin, R. A. Brown, B. Hitsman and M. J. Carpenter (2019). "Multi-method assessment of distress tolerance and smoking-related factors among adult daily smokers." Exp Clin Psychopharmacol 27(2): 136-145. PMID: 30589279
  • Tomko, R. L., Froeliger, B., McClure, E. A., Saladin, M.E., and Gray, K.M. (2019). Gender Differences in Smoking Latency Following Exposure to Stressful Images Administered in Naturalistic Settings. Journal of Womens Health. 28 (11): 1593-1593.
  • Tomko, R. L., E. A. McClure, P. A. Cato, J. B. Wang, M. J. Carpenter, J. L. Karelitz, Froeliger, B., M. E. Saladin and K. M. Gray (2019). "An electronic, smart lighter to measure cigarette smoking: A pilot study to assess feasibility and initial validity." Addict Behav 98: 106052. PMID: 31415971
  • Fridriksson, J.F., Rorden, C., Newman-Norlund, R., Froeliger, B., Thrasher, J. (2018). Smokers' Neurological Responses to Novel and Repeated Health Warning Labels (HWLs) from Cigarette Packages. Frontiers in Psychology.
  • Garland EL, Bryan CJ, Kreighbaum L, Nakamura Y, Howard MO & Froeliger B. (2018). Prescription opioid misusing chronic pain patients exhibit dysregulated context-dependent associations: Investigating associative learning in addiction with the Cue-Primed Reactivity Task. Drug and Alcohol Dependence. Mar 27;187:13-21.PMID: 29626741
  • Garland, E.L., Hanley, A.W., Bedford, C., Zubieta, J.-K., Howard, M.O., Nakamura, Y., Donaldson, G., & Froeliger, B. (2018). Reappraisal deficits promote craving and emotional distress among chronic pain patients at risk for prescription opioid misuse. Journal of Addictive Diseases. Jun 4:1-9. PMID: 29863439.
  • Serfaty, S., Gale, G., Beadman, M., Froeliger, B., & Kamboj, S. K. (2018). Mindfulness, Acceptance and Defusion Strategies in Smokers: a Systematic Review of Laboratory Studies. Mindfulness (N Y), 9(1), 44-58. doi:10.1007/s12671-017-0767-1
  • Badran, B.W., Austelle, C.W., Smith, N.R., Glusman, C.E., Froeliger, B., Garland, E.L., Borckardt, J.J., George, M.S., Short, B. (2017). A double-blind study exploring the use of transcranial direct current stimulation (tic’s) to potentially enhance mindfulness meditation (E-meditation). Brain Stimulation. Jan-Feb; 10 (1): 152-154. PMID: 27839723.
  • Carpenter MJ, Heckman BW, Wahlquist AE, Wagener TL, Goniewicz ML, Gray KM, Froeliger B, Cummings KM. A naturalistic, randomized pilot trial of e-cigarettes: Uptake, exposure, and behavioral effects. Cancer Epidemiology, Biomarkers & Prevention. 2017;26:1795-803. PMCID: 5713898.
  • Froeliger, B., Mathew, A.R., McConnell, P.A., Eichberg, C., Saladin, M.E., Carpenter, M.J., Garland, E.L. (2017). Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. Evidence-Based Complementary and Alternative Medicine: eCAM 2017.
  • Froeliger, B., McConnell, P.A., Sweitzer, M.A., Bell, S., Kozink, R.V., Eichberg, C., Gray, K.M., McClernon, F.J. (2017). Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability. JAMA Psychiatry. Mar 1. doi:10.1001/jamapsychiatry.2017.0017
  • Garland, E.L., Froeliger, B., Howard, M.O. (2017). Deficits in Autonomic Indices of Emotion Regulation and Reward Processing Associated with Prescription Opioid Use and Misuse. Psychopharmacology. Feb; 234 (4): 621-629, PMID: 27933366.
  • Garland, E.L., Howard, M.O.. Zubieta, J.K., Froeliger, B. (2017). Restructuring Hedonic Dysregulation in Chronic Pain and Prescription Opioid Misuse: Effects of Mindfulness-Oriented Recovery Enhancement on Responsiveness to Drug Cues and Natural Rewards. Psychotherapy and Psychosomatics. Feb 10;86(2):111-112. PMID: 28183077
  • Germeroth, L.J., Carpenter, M.J., Baker, N.L., Froeliger, B., LaRowe, S.D., Saladin, M.E. (2017). A Brief Memory Updating Intervention Significantly Attenuates Smoking Behavior. JAMA Psychiatry. Feb 1.PMID: 28146243.
  • Meier, E., Wahlquist, A.E., Heckman, B.W., Cummings, K.M., Froeliger, B., Carpenter, M.J. (2017). A Pilot Randomized Crossover Trial of E-cigarette Sampling Among Smokers. Nicotine and Tobacco Research, Feb; 19 (2): 176-182. PMID: 27613880.