Profile
Dr. Zaghouani is director of the Immunity & Autoimmunity Research Lab. His laboratory focuses on the biology of T lymphocytes and their contribution to the development of immunity and autoimmunity.
Academic Information
J. Lavenia Edwards Chair in Pediatrics
Professor
Office
One Hospital Drive
Columbia, MO 65212
United States
P. 573-884-0659
Research Interests
- T lymphocytes in immunity as well as autoimmunity
Areas of Expertise
- Type 1 diabetes in the non-obese diabetic mouse
- Experimental allergic encephalomyelitis
- Viral infection in newborn mice
Education & Training
Post-Graduate School
1987, PhD, University of Paris, France
Publications
- Ukah, T.K., A. N. Cattin-Roy, G. E. Davis and H. Zaghouani. (2021). Repair of islet vasculature sustains dual β-cell regeneration during recovery from T1D. Cellular. Immunol. 364(2021):1-10
- Zaghouani. H., and M.M. Miller. (2020). Early Life T-Helper 1 Immunity. Critical. Rev. Immunol. 40:407-411.
- Barik,* S., A.N. Cattin-Roy*, T.K. Ukah, M.M. Miller, E. Teixeiro, and H. Zaghouani. (2020). Type II cytokines fine-tune thymic T cell selection to offset murine central nervous system autoimmunity. J. Immunol. 205:2039-2045. *Co-first authors.
- Miller, MM, S Barik, AN Cattin-Roy, TK Ukah, and H Zaghouani. 2019. A new IRF-1-driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cell and weakens protection against viral infection. J. Immunol. 202:3173-3186.
- Barik, S, AN Cattin-Roy, MM Miller, TK Ukah, and H Zaghouani. 2018. IL-4 and IL-13 guide early thymic progenitors to mature towards thymic resident dendritic cells. J. Immunol. 201(10):2947-2958.
- Barik, S, MM Miller, AN Cattin-Roy, TK Ukah, and H Zaghouani. 2018. A distinct dendritic cell population arises in the thymus of IL-13Rα1-sufficient but not IL-13Rα1-deficient mice. Cellular Immunol. 331:130-136.
- Barik S, MM Miller, AN Cattin-Roy, TK Ukah, W Chen, H Zaghouani. 2017. IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage. J Immunol. 199: 2767-2776.
- Barik S, JS Ellis, JA Cascio, MM Miller, TK Ukah, AN Cattin-Roy, H Zaghouani. IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. J Immunol. 199: 2236-2248.
- Ukah, TK, AN Cattin-Roy, W Chen, MM Miller, S Barik, and H Zaghouani. 2017. On the Role of IL-4/IL-13 Heteroreceptor (HR) in Regulation of Type 1 Diabetes. J. Immunol. 2017 Aug 1; 199(3):894-902. Doi: 10/jimmunol.1700410. Epub2017 Jun 23.
- Chen, W, X Wan, TK Ukah, MM Miller, S Barik, AN Cattin-Roy, and H Zaghouani. 2016. Antigen Specific Immune Modulation Targets mTORC1 Function to Drive Chemokine Receptor-Mediated T Cell Tolerance. J. Immunol. 197:3554-3565
- Halim, TFY, YY Hwang, H Zaghouani, N Gabri, PG Fallon, and ANJ McKenzie. 2015. Group 2 Innate Lymphoid Cells license dendritic cells to potentiate memory T helper 2 cell responses. Nat. Immunol. Doi: 10.1038/ni.3294
- Sherman, MP, CJ Pritzl, C Xia, MM Miller, H Zaghouani, and B Hahm. 2015. Lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice. Biochem. Biophys. Res. Commun. Doi: 10.1016/j.bbrc.2015.10067
- Wahidi, L, JJ Sherman, MM Miller, H Zaghouani and MP Sherman. 2015. Early Persistent Blood Eosinophilia in Necrotizing Enterocolitis is a Predictor of Late Complications. Neonatology. 108: 137-142.
- Dhakal, M., M. M. Miller, AA Zaghouani, MP Sherman, and H Zaghouani. 2015. Neonatal basophils stifles the function of early life dendritic cells to curtail T helper 1 immunity in newborn mice. J. Immunol. 195:507-518.
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