Dr. Zaghouani’s laboratory focuses on the biology of T lymphocytes and their contribution to the development of immunity and autoimmunity.
The first of three projects investigates the role self-reactive T cells play in the development of type 1 diabetes (T1D) autoimmune disorder. Specifically, Dr. Zaghouani is investigating the mechanisms by which T lymphocytes develop in the thymus, what stimulates these autoreactive T cells to attack the insulin-producing beta cells, and how they can modulate the diabetogenic behavior of destructive T cells to cure T1D.
The second project investigates the mechanisms by which myelin‐reactive T cells develop in the thymus, and the reasoning these autoreactive cells are stimulated to cause experimental allergic encephalomyelitis (EAE). This includes animal models for human multiple sclerosis (MS), and how to control their aggressive behavior to halt the inflammatory process in the central nervous system and reverse the disease.
The third project utilizes a mouse model of neonatal immunity to delineate the mechanisms underlying the susceptibility of newborns and infant to microbial infections. Dr. Zaghouani has established that upon neonatal vaccination, the immune response of newborn mice displays a deficit in the T lymphocyte subset known as T helper 1 (Th1), the main mediator of immune defenses against infections.
One Hospital Drive
Columbia, MO 65212
- T lymphocytes in immunity as well as autoimmunity
Areas of Expertise
- Type 1 diabetes in the non-obese diabetic mouse
- Experimental allergic encephalomyelitis
- Viral infection in newborn mice
Education & Training
1987, PhD, University of Paris, France
- Miller, MM, S Barik, AN Cattin-Roy, TK Ukah, and H Zaghouani. 2019. A new IRF-1-driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cell and weakens protection against viral infection. J. Immunol. 202:3173-3186.
- Barik, S, AN Cattin-Roy, MM Miller, TK Ukah, and H Zaghouani. 2018. IL-4 and IL-13 guide early thymic progenitors to mature towards thymic resident dendritic cells. J. Immunol. 201(10):2947-2958.
- Barik, S, MM Miller, AN Cattin-Roy, TK Ukah, and H Zaghouani. 2018. A distinct dendritic cell population arises in the thymus of IL-13Rα1-sufficient but not IL-13Rα1-deficient mice. Cellular Immunol. 331:130-136.
- Barik S, MM Miller, AN Cattin-Roy, TK Ukah, W Chen, H Zaghouani. 2017. IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage. J Immunol. 199: 2767-2776.
- Barik S, JS Ellis, JA Cascio, MM Miller, TK Ukah, AN Cattin-Roy, H Zaghouani. IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. J Immunol. 199: 2236-2248.
- Ukah, TK, AN Cattin-Roy, W Chen, MM Miller, S Barik, and H Zaghouani. 2017. On the Role of IL-4/IL-13 Heteroreceptor (HR) in Regulation of Type 1 Diabetes. J. Immunol. 2017 Aug 1; 199(3):894-902. Doi: 10/jimmunol.1700410. Epub2017 Jun 23.
- Chen, W, X Wan, TK Ukah, MM Miller, S Barik, AN Cattin-Roy, and H Zaghouani. 2016. Antigen Specific Immune Modulation Targets mTORC1 Function to Drive Chemokine Receptor-Mediated T Cell Tolerance. J. Immunol. 197:3554-3565
- Halim, TFY, YY Hwang, H Zaghouani, N Gabri, PG Fallon, and ANJ McKenzie. 2015. Group 2 Innate Lymphoid Cells license dendritic cells to potentiate memory T helper 2 cell responses. Nat. Immunol. Doi: 10.1038/ni.3294
- Sherman, MP, CJ Pritzl, C Xia, MM Miller, H Zaghouani, and B Hahm. 2015. Lactoferrin acts as an adjuvant during influenza vaccination of neonatal mice. Biochem. Biophys. Res. Commun. Doi: 10.1016/j.bbrc.2015.10067
- Wahidi, L, JJ Sherman, MM Miller, H Zaghouani and MP Sherman. 2015. Early Persistent Blood Eosinophilia in Necrotizing Enterocolitis is a Predictor of Late Complications. Neonatology. 108: 137-142.
- Dhakal, M., M. M. Miller, AA Zaghouani, MP Sherman, and H Zaghouani. 2015. Neonatal basophils stifles the function of early life dendritic cells to curtail T helper 1 immunity in newborn mice. J. Immunol. 195:507-518.