Kempuraj Duraisamy, PhD

Duraisamy

Neurology

Assistant Research Professor

573-882-6573

Profile

Dr. Kempuraj Duraisamy is currently involved in research on biomarker analysis in the blood of neurotrauma patients and Parkinson’s disease patients. He also investigates on the role of immune response and mast cell activation in brain injury and stress associated Alzheimer’s disease pathogenesis using human brain samples, animal models of brain injury, Alzheimer’s disease and Parkinson’s disease. Dr. Duraisamy also investigates in-vitro cell culture model of brain injury, Alzheimer’s disease and Parkinson’s disease. He has published over 130 research articles as original articles, Review articles and Hypothesis articles.

Dr. Duraisamy is also actively involved in the Center for Translational Neuroscience at the University of Missouri. He is currently the co-Investigator in the biomarker analysis studies funded by the Leonard Wood Institute. He has a track record of successful and productive research in the area of mast cells in neuroinflammation, drug discovery, and basic and clinical research areas. Dr. Duraisamy’s ultimate goal is to identify the molecular mechanism involved in the pathogenesis of neurodegenerative diseases and neurotrauma and identify the effective and disease specific and disease modifying therapeutic options for these diseases.

Academic Information

Assistant Research Professor
P. 573-882-6573

Research Interests

  • Biomarker discovery in neurotrauma patients, Parkinson’s disease patients, animal models of Alzheimer’s disease and Parkinson’s disease
  • Stress, brain injury and Alzheimer’s disease pathogenesis
  • Brain cells, immune cells and mast cell interaction in neuroinflammation, neurodegeneration and neurodegenerative diseases
  • Inflammatory mediators in neuroinflammation, neurodegeneration and neurodegenerative diseases
  • Peripheral inflammation and mast cell activation in neuroinflammation, neurodegeneration and neurodegenerative diseases
  • Development of drug discovery: natural flavonoid compounds/nutritional supplements/anti-inflammatory drugs to treat various inflammatory conditions including neuroinflammatory disorders
  • Quantitative analysis of neuroinflammation and Blood-brain barrier/tight junction proteins
  • Peripheral biomarkers in brain tumor patients before and after surgery, radiotherapy and chemotherapy

Areas of Expertise

  • Stress and brain injury-associated Alzheimer’s disease pathogenesis
  • Neuroimmune response/mast cell activation in stress disorders, brain injury, stroke, neurotrauma/traumatic brain injury
  • Neuroinflammation-mediated neurodegeneration in neurodegenerative diseases
  • Mast cell activation in central nervous system and peripheral system disorders
  • Neuroinflammatory biomarkers in neuroinflammation and neurotrauma patients
  • Anti-inflammatory drug discovery, evaluation of anti-inflammatory drugs and dietary supplements to treat neuroinflammation, brain injury and neurodegenerative diseases
  • Neuroimmune responses in neuroprotection and neurodegeneration in the brain
  • Parkinson’s disease pathogenesis
  • Animal models of Alzheimer’s disease, Parkinson’s disease and brain injury
  • Neuroimmunomodulation in Brain tumor patients before and after treatment procedures

Education & Training

Medical School

University of Madras, Chennai, India

Awards & Honors

  • 1996-1998: Science and Technology Agencies (STA) Research Fellowship from Japan International Science and Technology Exchange Center (JISTEC) & Japan Research Development Corporation (JRDC) agencies, Japan
  • 1996: Nageswara Rao Pantulu Prize Award from University of Madras, India for the best research in the subject of Human Physiology
  • 1994: Indira Vasudevan Medal Award from Indian Association of Biomedical Scientists for the best research in cancer 1993-1994: International Cancer Research Technology Transfer Fellowship (ICRETT) Award from International Union Against Cancer (UICC) for research training at Brain Tumor Research Center, University of California, San Francisco, CA
  • 1993-1995: Research Fellowship from Indian Council of Medical Research (ICMR), New Delhi, India 1991-1994: Research Fellowship Award and International Travel Award from Council of Scientific and Industrial Research (CSIR), New Delhi, India 1991: International Travel/Research Fellowship Award from Birla Medical Trust, India
  • 1991: Research Fellowship Award from the Directorate General of Health Services (DGHS), New Delhi, India
  • 1990-1991: Research Fellowship Award from Lady Tata Memorial Trust (LTMT), Mumbai, India 1986: Research Fellowship Award from Indian Council of Agricultural Research (ICAR), New Delhi, India. 

Membership in Scientific Professional Societies

  • Inflammation Research Association (IRA)
  • Fellow in International Union Against Cancer (UICC)
  • International Brain Research Organization (IBRO)
  • International Society for Neurochemistry (ISN)

Journal Editorial Board

  • Journal of Neurology, Neurosurgery and Spine
  • Austin Neurology
  • Brain and Nerves
  • American Research Journal of Neurology
  • International Journal of Immunopathology and Pharmacology
  • Journal of Biological Regulators & Homeostatic Agents
  • Journal of Orthopedics

Journal Associate Editor

  • Frontiers in Neurology
  • Frontiers in Neuroscience
  • Frontiers in Psychiatry
  • Frontiers in Cellular Neuroscience

Publications

  • Kempuraj D, Thangavel R, Fattal R, Pattani S, Yang E, Zaheer S, Santillan DA, Santillan MK, Zaheer A. Mast cells release chemokine CCL2 in response to Parkinsonian toxin 1-methyl-4-phenyl-pyridinium (MPP+). Neurochem Res 41(5):1042-1049, 2016. Conti P, Kempuraj D. Important role of mast cells in multiple sclerosis. Multi Scler Relat Disord 5:77-80, 2016.
  • Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan DA, Santillan MK, Zaheer A. Dopaminergic toxin 1-methyl-4-phenylpyridinium, proteins alpha synuclein and glia maturation factor activate mast cells and release inflammatory mediators. PLoS One 10:e135776, 2015.
  • Khan MM, Zaheer S, Thangavel R, Patel M, Kempuraj D, Zaheer A. Absence of Glia maturation factor protects dopaminergic neurons and improves motor behavior in mouse model of Parkinsonism. Neurochem Res 40(5):980-990, 2015.
  • Xiong Z, Thangavel R, Kempuraj D, Zaheer A. Alzheimer’s disease: Evidence for the expression of inflammatory interleukin-33 and its receptor ST2 in brain. J Alzheimer’s Dis 40(2):297-308, 2014.
  • Khan MM, Kempuraj D, Zaheer S, Zaheer A. Glia maturation factor deficiency suppresses 1-Methyl-4-Phenylpyridinium-induced oxidative stress in astrocytes. J Mol Neurosci 53(4):590-599, 2014.
  • Kempuraj D, Khan MM, Thangavel R, Xiong Z, Yang E, Zaheer A. Glia Maturation Factor Induces Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases. J Neuroimmune Pharmacol. 8:643-650, 2013.
  • Thangavel R, Kempuraj D, Stolmeier D, Anantharam P, Khan MM, Zaheer A. Glia maturation factor expression in entorhinal cortex of Alzheimer’s disease brain. Neurochem Res. 38:1777-1784, 2013.
  • Stolmeier D, Thangavel R, Anantharam P, Khan MM, Kempuraj D, Zaheer A. Glia maturation factor expression in hippocampus of human Alzheimer’s disease. Neurochem Res. 38:1580-1589, 2013.
  • Khan MM, Kempuraj D, Thangavel R, Zaheer A. Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol. Neurochem Int. 62:379-388, 2013. Zaheer S, Thangavel R, Wu Y, Khan MM, Kempuraj D, Zaheer A. Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice. Neurochem Res. 38(1):218-25, 2013.
  • Yuan Z, Meyerholz D, Twait E, Kempuraj D, Williard D, Samuel I. Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis. J Gastrointest Surg 15(10):1670-1678, 2011.
  • Clemons A, Vasiadi M, Kempuraj D, Kourelis T, Vandoros G, Theoharides TC. Amitriptyline and Prochlorperazine Inhibit Proinflammatory Mediator Release From Human Mast Cells: Possible Relevance to Chronic Fatigue Syndrome. J Clin Psychopharmacol. 31:385-387, 2011.
  • Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos KD, Theoharides TC. Luteolin and thiosalicylate inhibit HgCl2 and thimerosal-induced VEGF release from human mast cells. Int J Immunopathol Pharmacol. 23(4):1015-20, 2010.
  • Castellani ML, Shaik-Dasthagirisaheb YB, Tripodi D, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Fulcheri M, Tetè S, Galzio R, Salini V, Caraffa A, Antinolfi P, Frydas I, Sabatino G, Kempuraj D. Interrelationship between vitamins and cytokines in immunity. J Biol Regul Homeost Agents 24(4):385-90, 2010.
  • Kempuraj D, Conti P, Vasiadi M, Alysandratos KD, Tagen M, Kalogeromitros D, Kourelis T, Gregoriou S, Makris M, Stavrianeas NG, Theoharides TC. IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells. Eur J Dermatol. 20(6):865-7, 2010.
  • Samuel I, Yuan Z, Meyerholz DK, Twait E, Williard DE, Kempuraj D. A novel model of severe gallstone pancreatitis: murine pancreatic duct ligation results in systemic inflammation and substantial mortality. Pancreatology 10(5):536-44, 2010.
  • Rozniecki JJ, Sahagian GG, Kempuraj D, Tao K, Jocobson S, Zhang B, Theoharides TC. Brain metastases of mouse mammary adenocarcinoma is increased by acute stress. Brain Res. 1366:204-10, 2010.
  • Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J, Tetè S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C, Cerulli G, Kempuraj D. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells. J Biol Regul Homeost Agents 24(2):131-5, 2010.
  • Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A, Antinolfi P, Conti P, Cuccurullo C, Ciampoli C, Felaco M, Orso C, Salini V, Cerulli G, Kempuraj D, Tetè S, Shaik B. Impact of RANTES, MCP-1 and IL-8 in mast cells. J Biol Regul Homeost Agents 24(1):1-6, 2010.
  • Kempuraj D, Asadi S, Zhang B, Manola A, Hogan J, Peterson E, Theoharides TC. Mercury induces inflammatory mediator release from human mast cells. J Neuroinflammation 7:20, 2010. Boucher W, Kempuraj D, Michaelian M, Theoharides TC. Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor. BJU Int. 106(9):1394-9, 2010.
  • Theoharides TC, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos KD, Kalogeromitros D, Asadi S, Stavrianeas N, Peterson E, Leeman S, Conti P. IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci U S A 107(9):4448-53, 2010.
  • Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol.183(10):6313-9, 2009.
  • Felaco P, Castellani ML, De Lutiis MA, Felaco M, Pandolfi F, Salini V, De Amicis D, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G, Caraffa A, Antinolfi P, Cuccurullo C, Perrella A, Theoharides TC, Conti P, Toniato E, Kempuraj D, Shaik YB. IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents 23(3):141-7, 2009. Vasiadi M, Kalogeromitros D, Kempuraj D, Clemons A, Theoharides TC. Rupatadine Inhibits Secretion from HMC-1 and LAD2 Human Mast Cells Int Arch Allergy Immunol. 151(1):38-45, 2009.
  • Theoharides TC, Kempuraj D, Redwood L. Autism - an emerging “neuroimmune disorder” in search of therapy. Expert Opin on Pharmacother 10(13):2127-43, 2009.
  • Castellani ML, Kempuraj D, Salini V, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G, Caraffa A, Antinolfi P, Theoharides TC, De Amicis D, Perrella A, Cuccurullo C, Boscolo P, Shaik Y. The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator. J Biol Regul Homeost Agents 23(1):11-4, 2009.
  • Castellani ML, Conti CM, Kempuraj D, Salini V, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G, Caraffa A, Antinolfi P, Galzio R, Shaik Y, Theoharides TC, De Amicis D, Perrella A, Cuccurullo C, Boscolo P, Felaco M, Doyle R, Verrocchio C, Fulcheri M. Autism and immunity: revisited study. Int J Immunopathol Pharmacol. 22(1):15-9, 2009.
  • Huang M, Kempuraj D, Papadopoulou N, Kourelis T, Donelan J, Manola A, Theoharides T. Urocortin induces IL-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-{kappa}B activation. J Mol Endocrinol. 42:397-405, 2009.
  • Theoharides TC, Kempuraj D, Marchand J, Tzianoumis L, Vasiadi M, Katsarou-Katsari A, Makris M, Kalogeromitros D. Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1.Clin Exp Dermatol. 34(5):e163-6, 2008.
  • Theoharides TC, Kempuraj D, Kourelis T, Manola A. Human mast cells stimulate activated T cells: Implications for multiple sclerosis. Ann N Y Acad Sci. 1144:74-82, 2008.
  • Theoharides TC, Kempuraj D, Vakali S, Sant GR. Treatment refractory interstitial cystitis/painful bladder syndrome with cystoprotek – an oral multi-agent natural supplement. Can J Urol. 15(6):4410-4414, 2008.
  • Theoharides TC, Rozniecki JJ, Sahagian G, Jocobson S, Kempuraj D, Conti P, Kalogeromitros D. Impact of stress and mast cell on brain metastases. J Neuroimmunol. 205(1-2):1-7, 2008.
  • Kalogeromitros D, Makris M, Chliva C, Aggelides X, Kempuraj D, Theoharides TC. A quercetin containing supplement reduces niacin-induced flush in humans. Int J Immunopathol Pharmacol. 21(3):509-14, 2008.
  • Kempuraj D, Tagen M, Iliopoulou B, Clemons A, Vasiadi M, Boucher W, House M, Wolfberg A, Theoharides TC. Luteolin inhibits myelin basic protein-induced human mast cells activation and mast cell-dependent stimulation of T cells. Br J Pharmacol.155:1076-84, 2008.
  • Papaliodis D, Boucher W, Kempuraj D, Michaelian M, Wolfberg A, House M, Theroharides TC. Niacin-induced “flush” involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model. J Pharmacol Exp Ther. 327 (3): 665-672, 2008.
  • Katsanos GS, Anogianaki A, Castellani ML, Ciampoli C, De Amicis D, Orso C, Pollice R, Vecchiet J, Tete S, Salini V, Caraffa A, Patruno A, Shail YB, Kempuraj D, Doyle R, Antinolfi PL, Cerulli G, Conti CM, Fulcheri M, Neri G, Sabatino G. Biology of neurotensin: revisited study. Int J Immunopathol Pharmacol. 21:255-259, 2008.
  • Boucher W, Stern JM, Kotsinyan V, Kempuraj D, Papaliodis D, Cohen MS, Theroharides TC. Intravesical nanocrystalline silver decreases experimental bladder inflammation.J Urol. 179(4):1598-602, 2008.
  • Papaliodis D, Boucher W, Kempuraj D, Theoharides TC. The flavonoid luteolin inhibits niacin-induced flush. Br J Pharmacol. 153:1382-1387, 2008.
  • Karapanou V, Kempuraj D, Theoharides TC. Interleukin-8 is increased in gingival crevicular fluid from patients with acute pulpitis. J Endod. 34(2):148-51, 2008.
  • Castellani ML, Ciampoli C, Felaco M, Tetè S, Conti CM, Salini V, De Amicis D, Orso C, Antinolfi PL, Caraffa A, Cerulli G, Boscolo P, Theoharides TC, Conti P, Kempuraj D. Neuropeptide substance P induces mRNA expression and secretion of CXCL8 chemokine, and HDC in human umbilical cord blood mast cells. Clin Invest Med. 31(6):E362-372, 2008.
  • Conti P, Castellani ML, Kempuraj D, Salini V, Vecchiet J, Tetè S, Mastrangelo F, Perrella A, De Lutiis MA, Tagen M, Theoharides TC. Role of mast cells in tumor growth. Ann Clin Lab Sci. 37(4):315-22, 2007.
  • Sugimoto K, Theoharides TC, Kempuraj D, Conti P. Response of spinal myoclonus to a combination therapy of autogenic training and biofeedback. Biopsychosoc Med. 1:18, 2007.
  • Castellani ML, Bhattacharya K, Tagen M, Kempuraj D, Perrella A, De Lutiis M, Boucher W, Conti P, Theoharides TC, Cerulli G, Salini V, Neri G. Anti-chemokine therapy for inflammatory diseases. Int J Immunopathol Pharmacol. 20(3):447-53, 2007.
  • Theoharides TC, Kempuraj D, Iliopoulou BP. Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis. Adv Exp Med Biol. 601:423-30, 2007.
  • Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D. Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev. 217:65-78, 2007. Sant GR, Kempuraj D, Marchand JE, Theoharides TC. The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology 69(4 Suppl):34-40, 2007.
  • Kalogeromitros D, Syrigou EK, Makris M, Kempuraj D, Stavrianeas NG, Vasiadi M, Theoharides TC. Nasal provocation of patients with allergic rhinitis and the ypothalamic-pituitary-adrenal axis. Ann Allergy Asthma Immunol. 98(3):269-73, 2007.
  • Bhattacharya K, Farwell K, Huang M, Kempuraj D, Donelan J, Papaliodis D, Vasiadi M, Theoharides TC. Mast cell deficient W/Wv mice have lower serum IL-6 and less cardiac tissue necrosis than their normal littermates following myocardial ischemia- eperfusion. Int J Immunopathol Pharmacol. 20(1):69-74, 2007.
  • Tagen M, Stiles L, Kalogeromitros D, Gregoriou S, Kempuraj D, Makris M, Donelan J, Vasiadi M, Staurianeas NG, Theoharides TC. Skin Corticotropin-Releasing Hormone Receptor Expression in Psoriasis. J Invest Dermatol. 127 (7):1789-91, 2007.
  • Boucher W, Kempuraj D, Cao J, Papaliodis D, Theoharides TC. Intravesical suplatast tosilate (IPD-1151T) inhibits experimental bladder inflammation. J Urol. 177(3):1186-90, 2007.
  • Castellani ML, Perrella A, Kempuraj D, Boucher W, Tagen M, Salini V, Vecchiet J, Tete S, Frydas S, Theoharides TC, Conti P. Immunological activation of human umbilical cord blood mast cells induces tryptase secretion and interleukin-6, and histidine decarboxilase mRNA gene expression. Pharmacol Res. 55(1):57-63, 2007.
  • Kalogeromitros D, Gregoriou S, Makris M, Georgala S, Kempuraj D, Theoharides TC. Secondary anetoderma associated with mastocytosis. Int Arch Allergy Immunol. 142(1):86-8, 2007.
  • Theoharides TC, Kempuraj D, Tagen M, Vasiadi M, Cetrulo CL. Human umbilical cord blood-derived mast cells: a unique model for the study of neuro-immuno-endocrine interactions. Stem Cell Rev. 2(2):143-54 2006.
  • Kempuraj D, Castellani ML, Petrarca C, Frydas S, Conti P, Theoharides TC, Vecchiet J.Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Clin Exp Med. 6(4):150-6, 2006.
  • Castellani ML, Kempuraj D, Frydas S, Theoharides TC, Simeonidou I, Conti P, Vecchiet J. Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Neuroimmunomodulation 13(3):179-86, 2006.
  • Vasiadi M, Kempuraj D, Boucher W, Kalogeromitros D, Theoharides TC. Progesterone inhibits mast cell secretion. Int J Immunopathol Pharmacol. 19(4):787-94, 2006.
  • Cao J, Boucher W, Kempuraj D, Donelan JM, Theoharides TC. Acute stress and intravesical corticotropin-releasing hormone induces mast cell dependent vascular endothelial growth factor release from mouse bladder explants. J Urol.176(3):1208-13, 2006.
  • Kandere-Grzybowska K, Kempuraj D, Cao J, Cetrulo CL, Theoharides TC. Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin. Br J Pharmacol. 148(2):208-15, 2006.
  • Kalogeromitros D, Kempuraj D, Katsarou-Katsari A, Makris M, Gregoriou S, Papaliodis D, Theoharides TC. Theophylline as 'add-on' therapy to cetirizine in patients with chronic idiopathic urticaria. A randomized, double-blind, placebo-controlled pilot study. Int Arch Allergy Immunol. 139(3):258-64, 2006.
  • Donelan J, Marchand JE, Kempuraj D, Papadopoulou N, Papaliodis D, Theoharides TC. Perifollicular and perivascular mouse skin mast cells express corticotropin-releasing hormone receptor. J Invest Dermatol.126(4):929-32, 2006.
  • Kempuraj D, Petrarca C, Frydas S, Riccioni G, Conti P, Tete S, Vecchiet J. Rat peritoneal mast cells release regulated upon activation normal T cell expressed and secreted (RANTES) after TNF-alpha activation. J Biol Regul Homeost Agents 19(3-4):130-5, 2005.
  • Trakatelli C, Frydas S, Hatzistilianou M, Papadopoulos E, Simeonidou I, Founta A, Paludi D, Petrarca C, Castellani ML, Papaioannou N, Salini V, Conti P, Kempuraj D, Vecchiet J. Chemokines as markers for parasite-induced inflammation and tumors. Int J Biol Markers 20(4):197-203, 2005.
  • Papadopoulou NG, Oleson L, Kempuraj D, Donelan J, Cetrulo CL, Theoharides TC. Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells. J Mol Endocrinol. 35(3):R1-8, 2005.
  • Theoharides TC, Papaliodis D, Tagen M, Konstantinidou A, Kempuraj D, Clemons A. Chronic fatigue syndrome, mast cells, and tricyclic antidepressants. J Clin Psychopharmacol. 25(6):515-20, 2005.
  • Kalogeromitros D, Kempuraj D, Katsarou-Katsari A, Gregoriou S, Makris M, Boucher W, Theoharides TC. Theophylline as "add-on" therapy in patients with delayed pressure urticaria: a prospective self-controlled study. Int J Immunopathol Pharmacol. 18(3):595-602, 2005.
  • Ramakrishnan R, Kempuraj D, Prabhakaran K, Jayakumar AR, Devi RS, Suthanthirarajan N, Namasivayam A. A short-term diabetes induced changes of catecholamines and p38-MAPK in discrete areas of rat brain. Life Sci. 77(15):1825-35, 2005.
  • Cao J, Papadopoulou N, Kempuraj D, Boucher WS, Sugimoto K, Cetrulo CL, Theoharides TC. Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol. 174(12):7665-75, 2005.
  • Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL, Theoharides TC. Flavonols inhibit proinflammatory mediator release, ntracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol. 145(7):934-44, 2005.
  • Petrarca C, Frydas S, Donelan J, Boucher W, Papadopoulou N, Cao J, Castellani ML, Conti P, Toniato E, Robuffo I, Vecchiet J, Iezzi T, Madhappan B, Kempuraj D. Interleukin 27 (IL-27): A novel pleiotropic cytokine involved in T cell differentiation and T cell response modulation. Int J Immunopathol Pharmacol. 18(2):191-4, 2005.
  • Di Giannantonio M, Frydas S, Kempuraj D, Karagouni E, Hatzistilianou M, Conti CM, Boucher W, Papadopoulou N, Donelan J, Cao J, Madhappan B, Boscolo P, Petrarca C, Castellani L, Quartesan L, Doyle R, Ferro FM. Cytokines in stress. Int J Immunopathol Pharmacol. 18(1):1-5, 2005.
  • Kempuraj D, Papadopoulou N, Stanford EJ, Christodoulou S, Madhappan B, Sant GR, Solage K, Adams T, Theoharides TC. Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin. Am J Reprod Immunol. 52(4):267-75, 2004.
  • Theoharides TC, Donelan JM, Papadopoulou N, Cao J, Kempuraj D, Conti P. Mast cells as targets of corticotropin-releasing factor and related peptides. Trends Pharmacol Sci. 25(11):563-8, 2004.
  • Frydas S, Karagouni E, Hatzistilianou M, Kempuraj D, Comani S, Petrarca C, Iezzi T, Verna N, Conti P, Castellani ML. Cytokines and allergic disorders: revisited study. Int J Immunopathol Pharmacol. 17(3):233-5, 2004.
  • Kempuraj D, Konstantinidou A, Boscolo P, Ferro F, Di Giannantonio M, Conti CM, Merlitti D, Petrarca C, Castellani ML, Doyle R, Theoharides TC. Cytokines and the brain. Int J Immunopathol Pharmacol. 17(3):229-32, 2004.
  • Kempuraj D, Donelan J, Frydas S, Iezzi T, Conti F, Boucher W, Papadopoulou NG, Madhappan B, Letourneau L, Cao J, Sabatino G, Meneghini F, Stellin L, Verna N, Riccioni G, Theoharides TC. Interleukin-28 and 29 (IL-28 and IL-29): new cytokines with anti-viral activities. Int J Immunopathol Pharmacol. 17(2):103-6, 2004.
  • Huang SH, Frydas S, Kempuraj D, Barbacane RC, Grilli A, Boucher W, Letourneau R, Madhappan B, Papadopoulou N, Verna N, De Lutiis MA, Iezzi T, Riccioni G, Theoharides TC, Conti P. Interleukin-17 and the interleukin-17 family member network. Allergy Asthma Proc. 25(1):17-21, 2004.
  • Kempuraj D, Devi RS, Madhappan B, Conti P, Nazer MY, Christodoulou S, Reginald J, Suthinthirarajan N, Namasivayam A. T lymphocyte subsets and immunoglobulins in intracranial tumor patients before and after treatment, and based on histological type of tumors. Int J Immunopathol Pharmacol. 17(1):57-64, 2004.
  • Huang SH, Frydas S, Conti P, Kempuraj D, Barbacane RC, Grilli A, Boucher W, Letourneau R, Papadopoulou N, Donelan J, Madhappan B, Theoharides TC, De Lutiis MA, Riccioni G, Sabatino G. Interleukin-17: a revisited study. Int J Immunopathol Pharmacol. 17(1):1-4, 2004.
  • Kempuraj D, Papadopoulou NG, Lytinas M, Huang M, Kandere-Grzybowska K, Madhappan B, Boucher W, Christodoulou S, Athanassiou A, Theoharides TC. Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells. Endocrinology 145(1):43-8, 2004.
  • Alexandrakis M, Letourneau R, Kempuraj D, Kandere-Grzybowska K, Huang M, Christodoulou S, Boucher W, Seretakis D, Theoharides TC. Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1). Eur J Haematol. 71(6):448-54, 2003.
  • Kempuraj D, Huang M, Kandere-Grzybowska K, Basu S, Boucher W, Letourneau R, Athanassiou A, Theoharides TC. Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells. Int Arch Allergy Immunol. 132(3):231-9, 2003.
  • Alexandrakis MG, Kyriakou DS, Kempuraj D, Huang M, Boucher W, Seretakis D, Theoharides TC. The isoflavone genistein inhibits proliferation and increases histamine content in human leukemic mast cells. Allergy Asthma Proc. 24(5):373-7, 2003.
  • Frydas S, Hatzistilianou M, Karagouni E, Madhappan B, D'Orazio N, Riccioni G, Conti F, Carratelli G, Kempuraj D. Chemokines and parasites. Int J Immunopathol Pharmacol. 16(3):221-4, 2003.
  • Kempuraj D, Frydas S, Conti P, Kandere- Grzybowska K, Boucher W, Letourneau R, Madhappan B, Huang SH, Sugimoto K, Papadopoulou NG, Christodoulou S, Theoharides TC. Interleukin-25 (or IL-17E): a new IL-17 family member with growth factor/inflammatory actions.Int J Immunopathol Pharmacol. 16(3):185-8, 2003.
  • Kandere-Grzybowska K, Letourneau R, Kempuraj D, Donelan J, Poplawski S, Boucher W, Athanassiou A, Theoharides TC. IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells. J Immunol. 171(9):4830-6, 2003.
  • Conti P, Kempuraj D, Frydas S, Kandere K, Boucher W, Letourneau R, Madhappan B, Sagimoto K, Christodoulou S, Theoharides TC. IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26. Immunol Lett. 88(3):171-4, 2003.
  • Kempuraj D, Frydas S, Kandere K, Madhappan B, Letourneau R, Christodoulou S, Boucher W, Riccioni G, Conti P, Theoharides TC. Interleukin-19 (IL-19) network revisited. Int J Immunopathol Pharmacol. 16(2):95-7, 2003.
  • Madhappan B, Kempuraj D, Christodoulou S, Tsapikidis S, Boucher W, Karagiannis V, Athanassiou A, Theoharides TC. High levels of intrauterine corticotropin-releasing hormone, urocortin, tryptase, and interleukin-8 in spontaneous abortions. Endocrinology 144(6):2285-90, 2003.
  • Lytinas M, Kempuraj D, Huang M, Boucher W, Esposito P, Theoharides TC. Acute stress results in skin corticotropin-releasing hormone secretion, mast cell activation and vascular permeability, an effect mimicked by intradermal corticotropin-releasing hormone and inhibited by histamine-1 receptor antagonists. Int Arch Allergy Immunol. 130(3):224-31, 2003.
  • Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Barbacane RC, Castellani ML, Felaco M, Boucher W, Letourneau R, Theoharides TC. IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett. 86(2):123-9, 2003.
  • Bielory L, Kempuraj D, Theoharides T. Topical immunopharmacology of ocular allergies. Curr Opin Allergy Clin Immunol. 2(5):435-45, 2002.
  • Alexandrakis MG, Kyriakou DS, Seretakis D, Boucher W, Letourneau R, Kempuraj D, Theoharides TC. Inhibitory effect of retinoic acid on proliferation, maturation and tryptase level in human leukemic mast cells (HMC-1). Int J Immunopathol Pharmacol. 16(1):43-7, 2003.
  • Frydas S, Madhappan B, Kempuraj D. Some aspects of Parasitology and Immunology in general Medicine. Int J Immunopathol Pharmacol. 15(3):165-170, 2002.
  • Conti P, Kempuraj D, Di Gioacchino M, Boucher W, Letourneau R, Kandere K, Barbacane RC, Reale M, Felaco M, Frydas S, Theoharides TC. Interleukin-6 and mast cells. Allergy Asthma Proc. 23(5):331-5, 2002.
  • Kempuraj D, Huang M, Kandere K, Boucher W, Letourneau R, Jeudy S, Fitzgerald K, Spear K, Athanasiou A, Theoharides TC. Azelastine is more potent than olopatadine n inhibiting interleukin-6 and tryptase release from human umbilical cord blood-derived cultured mast cells. Ann Allergy Asthma Immunol. 88(5):501-6, 2002.
  • Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Reale M, Barbacane RC, Castellani ML, Mortari U, Boucher W, Letourneau R, Theoharides TC. Interleukin-16 network in inflammation and allergy. Allergy Asthma Proc. 23(2):103-8, 2002.
  • Pehlivanidis C, Fotoulaki M, Boucher W, Kempuraj D, Pang X, Konstantinidou A, Theoharides TC. Acute stress-induced seizures and loss of consciousness in a ten-year-old boy with cutaneous astocytosis. J Clin Psychopharmacol. 22(2):221-4, 2002.
  • Lytinas M, Kempuraj D, Huang M, Kandere K, Boucher W, Letourneau R, Jeudy S, Fitzgerald K, Spear K, Athanasiou A, Theoharides TC. Azelastine's inhibition of histamine and tryptase release from human umbilical cord blood-derived cultured mast cells as well as rat skin mast cell-induced vascular permeability: comparison with olopatadine. Allergy Asthma Proc. 23(1):45-51, 2002.
  • Boucher WS, Letourneau R, Huang M, Kempuraj D, Green M, Sant GR, Theoharides TC. Intravesical sodium hyaluronate inhibits the rat urinary mast cell mediator increase triggered by acute immobilization stress. J Urol. 167(1):380-4, 2002.
  • Theoharides TC, Alexandrakis M, Kempuraj D, Lytinas M. Anti-inflammatory actions of flavonoids and structural requirements for new design. Int J Immunopathol Pharmacol. 14(3):119-127, 2001.
  • Conti P, Kempuraj D, Boucher W, Letourneau R, Theoharides TC. Mechanism by which IL-16 generated by mast cells mediates allergic inflammation. Int J Immunopathol Pharmacol. 14(1):1-4, 2001.
  • Theoharides TC, Kempuraj D, Sant GR. Massive extracellular tryptase from activated bladder mast cells in interstitial cystitis. Urology 58(4):605-6, 2001.
  • Theoharides TC, Kempuraj D, Sant GR. Mast cell involvement in interstitial cystitis: a review of human and experimental evidence. Urology 57(6 Suppl 1):47-55, 2001.
  • Theoharides TC, Patra P, Boucher W, Letourneau R, Kempuraj D, Chiang G, Jeudy S, Hesse L, Athanasiou A. Chondroitin sulphate inhibits connective tissue mast cells. Br J Pharmacol. 131(6):1039-49, 2000.
  • Ahn K, Takai S, Pawankar R, Kuramasu A, Ohtsu H, Kempuraj D, Tomita H, Iida M, Matsumoto K, Akasawa A, Miyazaki M, Saito H. Regulation of chymase production in human mast cell progenitors. J Allergy Clin Immunol. 106(2):321-8, 2000.
  • Kempuraj D, Saito H, Kaneko A, Fukagawa K, Nakayama M, Toru H, Tomikawa M, Tachimoto H, Ebisawa M, Akasawa A, Miyagi T, Kimura H, Nakajima T, Tsuji K, Nakahata T. Characterization of mast cell-committed progenitors present in human umbilical cord blood.Blood 93(10):3338-46, 1999.
  • Kanbe N, Kurosawa M, Miyachi Y, Kanbe M, Kempuraj D, Tachimoto H, Saito H. Carnoy's fixative reduces the number of chymase-positive cells in immunocytochemical staining of cord-blood-derived human cultured mast cells. Allergy 53(10):981-5, 1998.

Book/Chapter Publication

  • Kourelis T, Kempuraj D, Manola A and Theoharides TC. Umbilical cord blood derived mast cells as models for the study of inflammatory diseases. In: Perinatal Stem Cells. Editors Cetrulo CL, Cetrulo K
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