Lixing Reneker, PhD

Academic Information

Associate Professor
P. 573-884-0350

Research Interests

  • Signaling mechanisms in ocular lens and anterior segment development
  • Growth factor-signaling in Meibomian gland homeostasis, dysfunction and therapy

Areas of Expertise

  • Signaling mechanisms in ocular lens and anterior segment development
  • Growth factor-signaling in Meibomian gland homeostasis, dysfunction and therapy
  • Credentials

Education & Training

Medical School

Department of Biochemistry, College of Medicine, University of Iowa, Iowa City, Iowa; Department of Biochemistry, College of Medicine, University of Iowa, Iowa City, Iowa; Department of Biology, Fudan University, Shanghai, China

Fellowship

Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas

Awards & Honors

  • Member of NIH study section on Biology of the Visual System (BVS) 2012-2016.
  • Member of NIH study section on Anterior Eye Diseases (AED) 2010-2012.
  • Dorsett L. Spurgeon M.D. Distinguished Medical Research Award, University of Missouri School of Medicine 2003.
  • NIH NRSA postdoctoral fellowship award 1999.

Publications

  • Reneker LW, Silversides DW, Xu L, Overbeek PA. Formation of corneal endothelium is essential for anterior segment development - a transgenic mouse model of anterior segment dysgenesis. Development. 2000 Feb;127(3):533-42.
  • Reneker LW, Chen Q, Bloch A, Xie L, Schuster G, Overbeek PA. Chick delta1-crystallin enhancer influences mouse alphaA-crystallin promoter activity in transgenic mice. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4083-90.
  • Xie L, Overbeek PA, Reneker LW. Ras signaling is essential for lens cell proliferation and lens growth during development. Dev Biol. 2006 Oct 15;298(2):403-14.
  • Xie L, Chen H, Overbeek PA, Reneker LW. Elevated insulin-signaling in mouse lens disrupts the growth and differentiation pattern of the lens. Mol Vis 2007;13:397-407.
  • Maddala R, Reneker LW, Pendurthi B,Rao PV. Rho GDP dissociation inhibitor-mediated disruption of RhoGTPase activity impairs lens fiber cell migration, elongation and survival. Dev Biol 2008;315:217-31.
  • Reneker LW, Bloch A, Xie L, Overbeek PA, Ash JD. Induction of Corneal Myofibroblasts by Lens-derived Transforming Growth Factor beta1 (TGFbeta1): A Transgenic Mouse Model. Brain Res Bull. 2010; 81:287-96 (invited paper in special issue on eye diseases).
  • Reneker LW, Chen H, Overbeek PA. Activation of unfolded protein response in transgenic mouse lenses. Invest Ophthalmol Vis Sci. 2011;52:2100-8.
  • Upadhya D, Ogata M and Reneker LW. MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development 2013; 140:1573-82.
  • Zhang J, Upadhya D, Lu L, Reneker LW  Fibroblast growth factor receptor 2 (FGFR2) is required for corneal epithelial cell proliferation and differentiation during embryonic development. PLoS One 2015; 10: e0117089.
  • Xie Q, McGreal R, Harris R, Gao CY, Liu W, Reneker LW, Musil LS, Cvekl A  Regulation of c-Maf and alphaA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem 2016; 291: 3947-3958.
  • Reneker LW, Wang L, Irlmeier RT, Huang AJW Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse. Invest Ophthal Vis Sci 2017; 58:2638-2646.