Academic Information
Research Interests
- Signaling mechanisms in ocular lens and anterior segment development
- Growth factor-signaling in Meibomian gland homeostasis, dysfunction and therapy
Areas of Expertise
- Signaling mechanisms in ocular lens and anterior segment development
- Growth factor-signaling in Meibomian gland homeostasis, dysfunction and therapy
- Credentials
Education & Training
Medical School
Department of Biochemistry, College of Medicine, University of Iowa, Iowa City, Iowa; Department of Biochemistry, College of Medicine, University of Iowa, Iowa City, Iowa; Department of Biology, Fudan University, Shanghai, China
Fellowship
Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, Texas
Awards & Honors
- Member of NIH study section on Biology of the Visual System (BVS) 2012-2016.
- Member of NIH study section on Anterior Eye Diseases (AED) 2010-2012.
- Dorsett L. Spurgeon M.D. Distinguished Medical Research Award, University of Missouri School of Medicine 2003.
- NIH NRSA postdoctoral fellowship award 1999.
Publications
- Reneker LW, Silversides DW, Xu L, Overbeek PA. Formation of corneal endothelium is essential for anterior segment development - a transgenic mouse model of anterior segment dysgenesis. Development. 2000 Feb;127(3):533-42.
- Reneker LW, Chen Q, Bloch A, Xie L, Schuster G, Overbeek PA. Chick delta1-crystallin enhancer influences mouse alphaA-crystallin promoter activity in transgenic mice. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4083-90.
- Xie L, Overbeek PA, Reneker LW. Ras signaling is essential for lens cell proliferation and lens growth during development. Dev Biol. 2006 Oct 15;298(2):403-14.
- Xie L, Chen H, Overbeek PA, Reneker LW. Elevated insulin-signaling in mouse lens disrupts the growth and differentiation pattern of the lens. Mol Vis 2007;13:397-407.
- Maddala R, Reneker LW, Pendurthi B,Rao PV. Rho GDP dissociation inhibitor-mediated disruption of RhoGTPase activity impairs lens fiber cell migration, elongation and survival. Dev Biol 2008;315:217-31.
- Reneker LW, Bloch A, Xie L, Overbeek PA, Ash JD. Induction of Corneal Myofibroblasts by Lens-derived Transforming Growth Factor beta1 (TGFbeta1): A Transgenic Mouse Model. Brain Res Bull. 2010; 81:287-96 (invited paper in special issue on eye diseases).
- Reneker LW, Chen H, Overbeek PA. Activation of unfolded protein response in transgenic mouse lenses. Invest Ophthalmol Vis Sci. 2011;52:2100-8.
- Upadhya D, Ogata M and Reneker LW. MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development 2013; 140:1573-82.
- Zhang J, Upadhya D, Lu L, Reneker LW Fibroblast growth factor receptor 2 (FGFR2) is required for corneal epithelial cell proliferation and differentiation during embryonic development. PLoS One 2015; 10: e0117089.
- Xie Q, McGreal R, Harris R, Gao CY, Liu W, Reneker LW, Musil LS, Cvekl A Regulation of c-Maf and alphaA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem 2016; 291: 3947-3958.
- Reneker LW, Wang L, Irlmeier RT, Huang AJW Fibroblast Growth Factor Receptor 2 (FGFR2) Is Required for Meibomian Gland Homeostasis in the Adult Mouse. Invest Ophthal Vis Sci 2017; 58:2638-2646.