Dr. Martinez-Lemus's research is focused on vascular remodeling, the geometrical reorganization of wall components in blood vessels. Vascular remodeling plays an important role in numerous physiological and pathological phenomena. In particular it plays a preponderant role in the incidence of life-threatening cardiovascular events associated with hypertension, diabetes and ageing. The goal of Dr. Martinez-Lemus's research is to elucidate the mechanisms responsible for the remodeling process and to develop prophylactic and therapeutic interventions for manipulating the process in order to ameliorate cardiovascular disease.
134 Research Park
Columbia, MO 65211
- Vascular Physiology with emphasis on the mechanisms responsible for the acute and chronic control of vascular diameter in the microcirculation.
Areas of Expertise
- Vascular Remodeling
- Endothelial cell biology
- Vascular smooth muscle cell biology
- Extracellular matrix biology
- Oxidative stress
- Diabetes vasculopathies
- Cellular mechanotransduction
- Atomic force microscopy
- Confocal and multiphoton microscopy
- Intravital microscopy, image processing.
Education & Training
Cardiovascular Research Institute, Texas A&M University
MS, Auburn University; PhD, Texas A&M University; DVM, National Autonomous University of Mexico in Mexico City
Awards & Honors
- Recipient of the American Physiological Society Research Career Enhancement Award
- Member of the European Society for Microcirculation, the American Physiological Society, the Poultry Science Association, and the Microcirculatory Society.
- Associate Editor for the Physiology Section of the journal Poultry Science
- Reviewer of several physiological journals.
- Waitkus-Edwards K. R., L. A. Martinez-Lemus, X. Wu, J. P. Trzeciakowski, M. J. Davis, G. E. Davis, and G. A. Meininger, 2002. a4b1 Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction. Circ. Res. 90:473-480. (Featured in cover and editorial).
- Martinez-Lemus, L.A., X. Wu, E. Wilson, M. A. Hill, M. J. Davis, G. E. Davis, and G. A. Meininger, 2003. Integrins as unique receptors for vascular control. J. Vasc. Res. 40:211-233.
- Martinez-Lemus, L.A., M.A. Hill, S.S. Bolz, U. Pohl, and G.A. Meininger, 2004. Acute Mechanoadaptation of Vascular Smooth Muscle Cells in Response to Continuous Arteriolar Vasoconstriction: Implications for Functional Remodeling. FASEB J. 18:708-710.
- Martinez-Lemus, L.A., T. Crow, M.J. Davis, G.A. Meininger, 2005. a5b1 and avb3 integrin blockade inhibit the myogenic response of skeletal muscle resistance arterioles. Am. J. Physiol. 289:H322-H329.