University of Missouri researcher Dr. Luis Martinez-Lemus provides insights into the changing physiology of blood vessels.
Martinez-Lemus first became interested in vascular biology while trying to understand why pulmonary hypertension develops in poultry, causing issues for animals and farmers. Studying the processes behind the disease captured his interest in microcirculation: circulation of blood in the body’s smallest blood vessels.
At MU, Martinez-Lemus’ research is focused on the mechanisms responsible for structural changes to blood vessels — a process known as vascular remodeling. Vascular remodeling is a hallmark for numerous cardiovascular diseases, yet is not fully understood by scientists. Using sophisticated imaging instruments, Martinez-Lemus studies how blood vessels respond to diverse stimuli. His studies indicate that cells within vascular walls are more adaptable than was previously known, changing position in as little as four hours.
In recognition of his research expertise, Martinez-Lemus received the American Physiological Society Research Career Enhancement Award. He is a member of the European Society for Microcirculation, the American Physiological Society, the Poultry Science Association and the Microcirculatory Society. Martinez-Lemus also serves on the editorial board for Microcirculation and Frontiers in Vascular Physiology and acts as reviewer of several physiological journals.
Dr. Luis Martinez-Lemus is an associate professor of medical pharmacology and physiology in the School of Medicine and an investigator at Dalton Cardiovascular Research Center.
134 Research Park
Columbia, MO 65211
- Vascular Physiology with emphasis on the mechanisms responsible for the acute and chronic control of vascular diameter in the microcirculation.
Areas of Expertise
- Vascular Remodeling
- Endothelial cell biology
- Vascular smooth muscle cell biology
- Extracellular matrix biology
- Oxidative stress
- Diabetes vasculopathies
- Cellular mechanotransduction
- Atomic force microscopy
- Confocal and multiphoton microscopy
- Intravital microscopy, image processing.
Education & Training
Cardiovascular Research Institute, Texas A&M University
MS, Auburn University; PhD, Texas A&M University; DVM, National Autonomous University of Mexico in Mexico City
Awards & Honors
- Recipient of the American Physiological Society Research Career Enhancement Award
- Member of the European Society for Microcirculation, the American Physiological Society, the Poultry Science Association, and the Microcirculatory Society.
- Associate Editor for the Physiology Section of the journal Poultry Science
- Reviewer of several physiological journals.
- Waitkus-Edwards K. R., L. A. Martinez-Lemus, X. Wu, J. P. Trzeciakowski, M. J. Davis, G. E. Davis, and G. A. Meininger, 2002. a4b1 Integrin activation of L-type calcium channels in vascular smooth muscle causes arteriole vasoconstriction. Circ. Res. 90:473-480. (Featured in cover and editorial).
- Martinez-Lemus, L.A., X. Wu, E. Wilson, M. A. Hill, M. J. Davis, G. E. Davis, and G. A. Meininger, 2003. Integrins as unique receptors for vascular control. J. Vasc. Res. 40:211-233.
- Martinez-Lemus, L.A., M.A. Hill, S.S. Bolz, U. Pohl, and G.A. Meininger, 2004. Acute Mechanoadaptation of Vascular Smooth Muscle Cells in Response to Continuous Arteriolar Vasoconstriction: Implications for Functional Remodeling. FASEB J. 18:708-710.
- Martinez-Lemus, L.A., T. Crow, M.J. Davis, G.A. Meininger, 2005. a5b1 and avb3 integrin blockade inhibit the myogenic response of skeletal muscle resistance arterioles. Am. J. Physiol. 289:H322-H329.