Academic Information
Associate Research Professor
VA Research Investigator, Harry S. Truman Memorial Veterans Hospital
Investigator, Dalton Cardiovascular Research Center
Office
1500 Research Park Drive, Room 253
Dalton Cardiovascular Research Center
Columbia, MO 65211
United States
P. 573-882-4866
Research Interests
Molecular mechanisms of cancer metastasis
- Metastatic cancer cell interactions with microvascular endothelium.
- Biochemistry of cancer cell recognition and adhesion.
- Microvascular pathophysiology of hematogenous cancer metastasis.
- Antimetastatic drug testing.
Sex-related aspects of intracranial microvasculature
- Intracranial microvascular networks plasticity and remodeling in physiological and disease-related settings.
- Interactions between lymphatic/ glymphatic and blood microvessels within the cranium (focusing on vascular compartments of meninges, bone marrow, and the brain) relevant to health and disease, such as estrogen- and sleep-deprivation induced conditions.
Areas of Expertise
- Meningeal microvascular remodeling
- Fluorescence, confocal, ex vivo, and real time microscopy with video imaging and analysis
- Computerized quantitative image analysis
- Microdissection and microsurgery
- Metastasis-associated carbohydrate-mediated endothelial activation
- Molecular and biochemical processes supporting cancer/endothelial cells interaction, arrest, and retention
- Biochemical, cell biology and immunological techniques
- Cell culture
- Flow chamber models
Education & Training
Degrees
1982 MD, State Medical Institute, Chernivtsi, Ukraine
Postdoctoral Fellowship
2007 University of Missouri-Columbia, Department of Medical Pharmacology and Physiology
Awards & Honors
- 2008-2011 American Heart Association, Scientist Development Grant (National Center Research Program)
- 2005-2007 American Heart Association Postdoctoral Fellowship. Heartland Affiliate
- 2002-2005 NIH Ruth L. Kirschstein National Research Service Award (NRSA)
- 1993 Internal Medicine Category I Award, Ukrainian Ministry of Public Health, Kiev, Ukraine
Publications
- Maruf Hossain Shuvo, Kassim YM, Bunyak F, Glinskii OV, Xie L, Glinsky VV, Huxley VH, Thakkar MM, Palaniappan K.
Multi-focus Image Fusion for Confocal Microscopy Using U-Net Regression Map.
International Conference on Pattern Recognition (ICPR), 2021 - Aktar R, Huxley VH, Guidoboni G, Glinskii OV, Palaniappan K.
Interactive Global Mosaic Stitching from Mesentery Video Sequeneces.
2020 IEEE Applied Imagery Pattern Recognition Workshop (AIPR). DOI: 10.1109/AIPR50011.2020.9425109 - Glinskii OV, Huxley VH, Xie L, Bunyak F, Palaniappan K and Glinsky VV.
Complex Nonsinus-associated Pachymeningeal Lymphatic Structures: Interrelationship with Blood Microvasculature. Front. Physiol. 2019 10:1364. doi: 10.3389/fphys.2019.01364.
eCollection 2019 - Kassim YM, Glinskii OV, Glinsky VV, Huxley VH, Guidoboni G and Palaniappan K.
Deep UNet Regression and Hand-Crafted Feature Fusion for Accurate Blood Vessel Segmentation.
2019 IEEE International Conference on Image Processing (ICIP), Taipei, Taiwan, 2019, pp. 1445-1449. doi:10.1109/ICIP.2019.8803084 - Kassim YM, Glinskii OV, Glinsky VV, Huxley VH, Palaniappan K.
Patch-based Semantic segmentation for detecting arterioles and venules in epifluorescence imagery.
2018 IEEE Applied Imagery Pattern Recognition Workshop (AIPR), Washington, DC, USA, 2018, pp.1-5. DOI: 10.1109/AIPR.2018.8707387 - Xie L, Sun Z, Hong Z, Brown NJ, Glinskii OV, Rittenhouse-Olson K, Meininger GA, Glinsky VV.
Temporal and molecular dynamics of human metastatic breast carcinoma cell adhesive interactions with human bone marrow endothelium analyzed by single-cell force spectroscopy.
PLoS ONE 2018 13(9): e0204418. https://doi.org/10.1371/journal.pone.0204418
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