Ronald J. Korthuis, PhD

Ronald Korthuis, PhD

Medical Pharmacology and Physiology

Professor
George L. and Melna A. Bolm Distinguished Chair in Cardiovascular Health

573-882-8029

Profile

Our research focuses on the mechanisms underlying the inflammatory responses to ischemia and reperfusion (I/R) and how blood vessels in the microcirculation (arterioles, capillaries, and venules) can be preconditioned to resist the deleterious inflammatory effects I/R. When the blood supply is reduced (ischemia) and then subsequently reestablished (reperfusion), the ability of arterioles to regulate the distribution of blood flow is impaired, many capillaries fail to perfuse (capillary no-reflow), and white blood cells become adherent to and emigrate across the walls of postcapillary venules. In addition, the permeability of the cells lining capillaries and postcapillary venules is increased, leading to edema formation. We are studying how white blood cells which adhere to and emigrate across the walls of postcapillary venules alter vasoregulatory function in arterioles, cause no-reflow in capillaries, and increase permeability in postcapillary venules. Another line of investigation focuses on understanding how exposing tissues to preconditioning stimuli such as short periods of ischemia or ethanol (at doses equivalent to drinking one to two alcoholic beverages) 24 hours prior to the onset of prolonged ischemia followed by reperfusion prevents microvascular dysfunction. Using a variety of pharmacologic approaches and mutant mouse models, we are examining the signaling mechanisms that are triggered by exposure to preconditioning stimuli to induce the formation of protective proteins such as heme oxygenase.

Academic Information

Professor
George L. and Melna A. Bolm Distinguished Chair in Cardiovascular Health

Office

1 Hospital Drive
Columbia, MO 65212
United States

P. 573-882-8029

Research Interests

  • Inflammatory responses to ischemia and reperfusion (I/R)

Areas of Expertise

  • Microcirculation
  • Inflammation
  • Alcohol Research
  • Septic Shock

Education & Training

Post-Graduate School

1983, PhD in Physiology, Michigan State University

Awards & Honors

  • Established Investigatorship, American Heart Association, 1988-1993.
  • Member, Cardiovascular and Renal B Study Section, (1995-1999); Pathophysiology of the Organ Systems (2003-2007); Vascular Cell and Molecular Biology (2007-2011) National Heart, Lung, and Blood institution
  • Fellow of the Cardiovascular Section of the American Physiological Society
  • Fellow of the Council on Basic Sciences of the American Heart Association
  • Alpha Omega Alpha National Medical Honor Society, Elected Faculty Member, 2011
  • Gold Chalk Award for Dedication and Service to the Advancement of Graduate Student Education, University of Missouri-Columbia, 2007
  • Elected to the Order of Socrates for Excellence in Medical Education, University of Missouri, 2006
  • CC Chou Endowed Lectureship, Michigan State University, 2004
  • Allen A. Copping Award for Excellence in Teaching, Louisiana State University Health Sciences Center, 2003
  • European Society for Microcirculation Travel Award to the XV European Conference on Microcirculation, Maastricht, The Netherlands, 1988
  • U.S. Microcirculatory Society Travel Award to Third World Congress for Microcirculation, Oxford, England, 1984
  • Jerry B. Scott Award for Excellence in Teaching, Michigan State University, 1983
  • Outstanding Graduate Student, Department of Physiology, Michigan State University, 1983
  • NIH Predoctoral Fellow, Michigan State University, East Lansing, Michigan, 1978 to 1983
  • Phi Kappa Phi Honor Society; Phi Theta Kappa Honor Society

Editorial Boards:

  • American Journal of Physiology: Heart and Circulatory Physiology, 1987-1999; 2005-present
  • Cardiovascular Research 2008-2012
  • Circulation Research 2010-2014
  • Journal of Applied Physiology, 1991-1993
  • Microcirculation, 1993-2010
  • Pathophysiology, 2005-2008
  • PLoS One, Academic Editor, 2013-2016
  • Frontiers in Vascular Physiology, Associate Editor, 2010-present

Publications

  • Fay WP, Korthuis RJ.  No Sweetie Pie: Newly Uncovered Role for PAI (Plasminogen Activator Inhibitor)-1 in Inflammatory Responses to Ischemia/Reperfusion.  Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):695-697. doi: 10.1161/ATVBAHA.118.310824
  • Qiu T, Li M, Tanner MA, Yang Y, Sowers JR, Korthuis RJ, Hill MA.  Depletion of dendritic cells in perivascular adipose tissue improves arterial relaxation responses in type 2 diabetic mice.  Metabolism. 2018 Mar 9. pii: S0026-0495(18)30068-4. doi: 10.1016/j.metabol.2018.03.002. 
  • Yu H, Wang M, Wang D, Kalogeris TJ, McHowat J, Ford DA, Korthuis RJ.  Chlorinated Lipids Elicit Inflammatory Responses In Vitro and In Vivo.  Shock. 2018 Feb 1. doi: 10.1097/SHK.0000000000001112. [Epub ahead of print]
  • Korthuis RJ.  Mechanisms of I/R-Induced Endothelium-Dependent Vasodilator Dysfunction.  Adv Pharmacol. 2018;81:331-364. doi: 10.1016/bs.apha.2017.08.001. 
  • Dai H, Wang M, Patel PN, Kalogeris T, Liu Y, Durante W, Korthuis RJ.  Preconditioning with the BKCa channel activator NS-1619 prevents ischemia-reperfusion-induced inflammation and mucosal barrier dysfunction: roles for ROS and heme oxygenase-1.  Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H988-H999. doi: 10.1152/ajpheart.00620.2016.  
  • Restrepo RJ, Lim RW, Korthuis RJ, Shukla SD.  Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation.  Alcohol. 2017 May;60:77-82. doi: 10.1016/j.alcohol.2017.01.009. 
  • Kalogeris T, Baines CP, Krenz M, Korthuis RJ.  Ischemia/Reperfusion.  Compr Physiol. 2016 Dec 6;7(1):113-170. doi: 10.1002/cphy.c160006. 
  • Wang DZ, Jones AW, Wang WZ, Wang M, Korthuis RJ.  Soluble guanylate cyclase activation during ischemic injury in mice protects against postischemic inflammation at the mitochondrial level.  Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G747-56. doi: 10.1152/ajpgi.00323.2015
  • Zuidema MY, Korthuis RJ.  Intravital microscopic methods to evaluate anti-inflammatory effects and signaling mechanisms evoked by hydrogen sulfide.  Methods Enzymol. 2015;555:93-125. doi: 10.1016/bs.mie.2014.11.022. 
  • Kalogeris T, Bao Y, Korthuis RJ.  Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning.  Redox Biol. 2014 Jun 2;2:702-14. doi: 10.1016/j.redox.2014.05.006. 
  • Kalogeris TJ, Baines C, Korthuis RJ.  Adenosine prevents TNFα-induced decrease in endothelial mitochondrial mass via activation of eNOS-PGC-1α regulatory axis.  PLoS One. 2014 Jun 10;9(6):e98459. doi: 10.1371/journal.pone.0098459. 
  • Turlo KA, Scapa J, Bagher P, Jones AW, Feil R, Korthuis RJ, Segal SS, Iruela-Arispe ML.  β1-integrin is essential for vasoregulation and smooth muscle survival in vivo.  Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2325-35. doi: 10.1161/ATVBAHA.112.300648. 
  • Wang WZ, Jones AW, Wang M, Durante W, Korthuis RJ.  Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.  Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H521-32. doi: 10.1152/ajpheart.00810.2012.
  • Yang Y, Sohma Y, Nourian Z, Ella SR, Li M, Stupica A, Korthuis RJ, Davis MJ, Braun AP, Hill MA.  Mechanisms underlying regional differences in the Ca2+ sensitivity of BK(Ca) current in arteriolar smooth muscle.  J Physiol. 2013 Mar 1;591(5):1277-93. doi: 10.1113/jphysiol.2012.241562. 
  • Korthuis RJ, Kalogeris T.  TRPing up reperfusion: neutrophil TRPM2 channels exacerbate necrosis and contractile dysfunction in post-ischaemic myocardium.  Cardiovasc Res. 2013 Feb 1;97(2):197-9. doi: 10.1093/cvr/cvs365. 
  • Kalogeris T, Baines CP, Krenz M, Korthuis RJ.  Cell biology of ischemia/reperfusion injury.  Int Rev Cell Mol Biol. 2012;298:229-317. doi: 10.1016/B978-0-12-394309-5.00006-7.