Selvakumar Govindhasamy Pushpavathi, PhD

Pushpavathi

Neurology

Post-Doctoral Fellow

Academic Information

Post-Doctoral Fellow

Research Interests

  • Experimental parkinson’s disease
  • Tardive dyskinesia and molecular neuropathology,
  • Dietary antioxidants
  • Neuro-Inflammation
  • Apoptosis
  • Autophagy
  • Astro-gliosis action and animal behavioral studies

Areas of Expertise

  • Experimental parkinson’s disease
  • Tardive dyskinesia and molecular neuropathology,
  • Dietary antioxidants
  • Neuro-Inflammation
  • Apoptosis
  • Autophagy
  • Astro-gliosis action and animal behavioral studies

Education & Training

Medical School

Annamalai University, Tamilnadu, India; Bharathidasan University, Tamilnadu, India

Awards & Honors

  • 2011-2014: Basic Science Research - Research Fellowship for Science Meritorious Students - (RFSMS-BSR) - Awarded by University Grants Commission (UGC), New Delhi, India

Publications

  • Selvakumar GP, Janakiraman U, Essa MM, Thenmozhi AJ, Manivasagam T. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson׳s disease. Brain Research. 2014; 1585:23-36.
  • Selvakumar GP, Manivasagam T, Rekha KR, Jayaraj RL, Elangovan N. Escin, a Novel Triterpene, Mitigates Chronic MPTP/p-Induced Dopaminergic Toxicity by Attenuating Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis. Journal of Molecular Neuroscience. 2015; 55(1):184-197.
  • Kavitha M, Manivasagam T, Essa MM, Tamilselvam K, Selvakumar GP, Karthikeyan S, Thenmozhi JA, Subash S. Mangiferin antagonizes rotenone: induced apoptosis through attenuating mitochondrial dysfunction and oxidative stress in SK-N-SH neuroblastoma cells. Neurochemical Research. 2014; 39(4):668-676.
  • Rekha KR, Selvakumar GP, Sethupathy S, Santha K, R Inmozhi Sivakamasundari. Geraniol Ameliorates the Motor Behavior and Neurotrophic Factors Inadequacy in MPTP-Induced Mice Model of Parkinson’s Disease. Journal of Molecular Neuroscience. 2013; 51:851–862.
  • Rekha KR, Selvakumar GP, Santha K, R Inmozhi Sivakamasundari. Geraniol attenuatesa-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner. Biochemical and Biophysical Research Communications. 2013; 440:664-670.
  • Rekha KR, Selvakumar GP. Gene expression regulation of Bcl2, Bax and Cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson's disease. Chemico-Biological Interactions. 2014; 217: 57–66.
  • Rekha KR, Selvakumar GP, Inmozhi Sivakamasundari R. Effects of syringic acid on chronic MPTP/probenecid induced motor dysfunction, dopaminergic markers expression and neuroinflammation in C57BL/6 mice. Biomedicine & Aging Pathology. 2014; 4: 95–104.
  • Rekha KR, Selvakumar GP, Sri Kumaran N, Marichamy G. Neuroprotective effects of S-allyl cystene on haloperidol induced neurotoxicity in rat. International Journal of Pharmacy and Pharmaceutical Sciences. 2012; 4 (3).
  • Rekha KR, Selvakumar GP, Sri Kumaran N. S-Allyl Cysteine Improves the Behavioral Phenotype and UCH-l1 Expression in Haloperidol Induced Neurotoxicity in Rats. IJPRT 2012; 4 (2) 111-120.
  • Selvakumar GP, Anandhan A, Manivasagam T. Neurotoxicity Associated with Neuroleptic Haloperidol Induced Tardive Dyskinesia in Albino Mice: Protective Role of Morin. Journal of Pharmacy Research 2012, 5(7), 3633-3639.
  • Selvakumar GP, Vijayraja D, Mohankumar K, Manivasagam T. Morin Attenuates Haloperidol Induced Tardive Dyskinesia and Oxidative Stress in Mice. Journal of Natural Sciences Research. 2012; 2(8):153-165.