Shivendra D. Shukla, PhD

Shivendra D. Shukla, PhD

Medical Pharmacology and Physiology

Margaret Proctor Mulligan Professor of Medical Research


Academic Information

Margaret Proctor Mulligan Professor of Medical Research


M531 Med Sci Bldg
Columbia, MO 65212
United States

P. 573-882-2740

Research Interests

  • Epigenetic and cell signaling effects of ethanol on liver
  • Platelets and vascular remodeling

Education & Training


University of Birmingham (England)

Post-Graduate School

PhD, University of Liverpool (England)


  • James, T, Aroor AR, Lim RW and Shukla SD. Histone H3 phosphorylation (S10, S28) and phosphoacetylation (K9/S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol. J. Pharm. & Exp. Ther. 340, 237-247, 2012.
  • Park P, Lim, RW and Shukla SD. Gene selective histone H3 acetylation in the absence of increase in global histone acetylation in liver of rats chronically fed alcohol. Alcohol & Alcoholism 47, 233-239, 2012.
  • Aroor AR, Jackson DE and Shukla SD. Dysregulated phosphorylation and nuclear translocation of cyclic-AMP response element binding protein (CREB) in rat liver after chronic ethanol binge. Eur J. Pharm. 679, 101-108, 2012.
  • Aroor AR, Lowery J Roy, Restrepo RJ, Mooney BP and Shukla SD. A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats. Proteome Science 10:29, 1-12, 2012.
  • Shukla SD and Lim RW. Epigenetic effects of ethanol on the liver and gastrointestinal system, Alcohol Research: Current Reviews, 35(1), 47-55, 2013.
  • Aroor AR, Restrepo RJ, Kharbanda, KK, and Shukla SD, Epigenetic histone modifications in a clinically relevant rat model of chronic-binge-mediated liver injury. Hepatology International. 8(2), 421-430, 2014
  • Shukla SD, Restrepo RJ, Fish P, Lim RW and Ibdah JA. Different mechanisms for histone acetylation by ethanol and its metabolite acetate in rat primary hepatocytes. J. Pharm & Exp Ther 354, 18-23, 2015.
  • Shukla SD, Aroor AR, Restrepo R, Kharbanda KK and Ibdah JA. In vivo acute on chronic ethanol effects in liver: A mouse model exhibiting exacerbated injury, altered metabolic & epigenetic responses. Biomolecules, 5, 3280-3294, 2015.
  • Szary N, Rector RS, Uptergrove GM, Ridenhour S, Shukla SD, Thyfault JP, Koch LG, Britton SL and Ibdah JA. High intrinsic aerobic capacity protects against ethanol-induced hepatic injury and metabolic dysfunction: study using inbred high capacity runner rat model. Biomolecules 5, 3295-3308, 2015.
  • Restrepo RJ, Lim RW, Korthuis RJ and Shukla SD. Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation. Alcohol 60, 77-82, 2017.