Shiying Jin, PhD

Profile

Shiying Jin, PhD, is a researcher who focuses on adult stem cell, tissue regeneration and cancer in the human endometrium. This research provides fundamental information for diagnosis, prevention and treatment of gynecological diseases to improve women’s reproductive and general health. Dr. Jin is the first investigator to identify the endometrial epithelial stem cells in mice, the founder cells regulating endometrial homeostasis and regeneration. Dr. Jin and his team are studying normal and cancer stem cells in the human endometrium for human endometrial regeneration and target therapy of endometrial cancer. Another main research focus in Dr. Jin's laboratory is to develop cellular therapy and immunotherapy for solid tumor treatment. Dr. Jin has mentored and trained many undergraduates, medical students, clinical fellows and research fellows for their career achievement. Dr. Jin also gives lectures to the medical school students.

Academic Information

Associate Research Professor

Office

920 East Campus Dr
Columbia, MO 65211
United States

Research Interests

  • Adult stem cells & tissue regeneration in mouse and human endometrium
  • Cancer stem cells in human endometrial cancer
  • Cellular Therapy & Immunotherapy for human solid tumor

Areas of Expertise

  • Stem cell biology
  • Reproductive biology/medicine
  • Macrophage & T cells biology
  • Cancer biology
  • Human IVF

Education & Training

Fellowship

Carnegie Institution for Science

Awards & Honors

  • NIH 1R56HD104821-01A1
  • NIH Oncofertility T90 Grant Globally Ready Scholar
  • Alpern Award in Stem Cell Biology, School of Medicine, University of Michigan

Publications

  • Yan H, Miranda EAD, Jin S, Wilson F, An K, Godbee B, Zheng X, Brau-Rodríguez AR, Lei L.
    Primary oocytes with cellular senescence features are involved in ovarian aging in mice.
    Sci Rep. 2024 Jun 13;14(1):13606. PMCID: PMC11176158.
  • Cousins FL, Pandoy R, Jin S, Gargett CE.
    The Elusive Endometrial Epithelial Stem/Progenitor Cells.
    Front Cell Dev Biol. 2021 Apr 9;9:640319. PMCID: PMC8063057.
  • Jin S, Martinelli DC, Zheng X, Tessier-Lavigne M, Fan CM.
    Gas1 is a receptor for sonic hedgehog to repel enteric axons.
    Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E73-80. PMCID: PMC4291612.
  • Jin S.
    Bipotent stem cells support the cyclical regeneration of endometrial epithelium of the murine uterus.
    Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6848-6857. PMCID: PMC6452687.