Timothy L Domeier, PhD

Timothy L Domeier, PhD

Medical Pharmacology and Physiology

Associate Professor
Margaret Proctor Mulligan Professorship in Medical Research



Dr. Domeier's research program investigates the mechanisms by which calcium homeostasis and cardiac muscle contractile function are altered in disease conditions including heart failure, cardiomyopathy, muscular dystrophy, and arrhythmia.

Cardiac Cell Physiology Lab

Academic Information

Associate Professor
Margaret Proctor Mulligan Professorship in Medical Research


One Hospital Drive
Columbia, MO 65212
United States

P. 573-884-1213

Research Interests

  • Cardiovascular Physiology
  • Calcium Homeostasis
  • Cardiac Aging
  • Cardiomyopathy and Cardiac Failure

Areas of Expertise

  • Cardiovascular Physiology
  • Muscle Cell Physiology
  • Intracellular Calcium Regulation
  • Single- and Multi-photon fluorescence microscopy

Education & Training


2010, Rush University
2008, Loyola University - Chicago

Post-Graduate School

2006, PhD, Cellular and Molecular Physiology, Yale University

Awards & Honors

  • Margaret Proctor Mulligan Endowed Professorship in Medical Research
  • Dorsett L. Spurgeon MD Distinguished Medical Research Award
  • University of Missouri Faculty Scholar
  • NIH Career Development Award
  • NIH Individual Postdoctoral National Research Service Award
  • American Heart Association Postdoctoral Fellowship
  • NIH Individual Predoctoral National Research Service Award
  • Yale University Prize Teaching Fellowship
  • University of Nebraska Regents Scholar


  • Li J, Kelly SC, Ivey JR, Thorne PK, Yamada KP, Aikawa T, Mazurek R, Turk JR, Silva KAS, Amin AR, Tharp DL, Mueller CM, Thakur H, Leary EV, Domeier TL, Rector RS, Fish K, Cividini F, Ishikawa K, Emter CA, Kapiloff MS. Distribution of cardiomyocyte-selective adeno-associated virus serotype 9 vectors in swine following intracoronary and intravenous infusion. Physiol Genomics. 2022 Jul 1;54(7):261-272.
  • Liu X, Wang A, Chen Z, Cui Y, Hao H, Domeier TL, Sun Q, Liu Z. Tempol Preserves Endothelial Progenitor Cells in Male Mice with Ambient Fine Particulate Matter Exposure. Biomedicines. 2022 Jan 29;10(2):327.
  • Peana D, Polo-Parada L, Domeier TL. Arrhythmogenesis in the aged heart following ischaemia-reperfusion: role of transient receptor potential vanilloid 4. Cardiovasc Res. 2022 Mar 16;118(4):1126-1137.
  • Kelly SC, Rau CD, Ouyang A, Thorne PK, Olver TD, Edwards JC, Domeier TL, Padilla J, Grisanti LA, Fleenor BS, Wang Y, Rector RS, Emter CA. The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature. Physiol Genomics. 2021 Mar 1;53(3):99-115.
  • Silva KAS, Leary EV, Olver TD, Domeier TL, Padilla J, Rector RS, Emter CA. Tissue-specific small heat shock protein 20 activation is not associated with traditional autophagy markers in Ossabaw swine with cardiometabolic heart failure. Am J Physiol Heart Circ Physiol. 2020 Nov 1;319(5):H1036-H1043.
  • Sowers JR, Habibi J, Jia G, Bostick B, Manrique-Acevedo C, Lastra G, Yang Y, Chen D, Sun Z, Domeier TL, Durante W, Whaley-Connell AT, Hill MA, Jaisser F, DeMarco VG, Aroor AR. Endothelial sodium channel activation promotes cardiac stiffness and diastolic dysfunction in Western diet fed female mice. Metabolism. 2020 Aug;109:154223.
  • Veteto AB, Peana D, Lambert MD, McDonald KS, Domeier TL. Transient receptor potential vanilloid-4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart. Cardiovasc Res. 2020 Sep 1;116(11):1887-1896.
  • Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, Rau C, Warren CM, Klutho PJ, Alex L, Ferreira-Nichols SC, Ivey JR, Thorne PK, McDonald KS, Krenz M, Baines CP, Solaro RJ, Wang Y, Ford DA, Domeier TL, Padilla J, Rector RS, Emter CA. Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. JACC Basic Transl Sci. 2019 Jun 24;4(3):404-421.
  • Jones JL, Peana D, Veteto AB, Lambert MD, Nourian Z, Karasseva NG, Hill MA, Lindman BR, Baines CP, Krenz M, Domeier TL. TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress. Cardiovasc Res 2019 Jan 1;115(1):46-56.
  • Hiemstra JA, Veteto AB, Lambert MD, Olver TD, Ferguson BS, McDonald KS, Emter CA, Domeier TL. Chronic low-intensity exercise attenuates cardiomyocyte contractile dysfunction and impaired adrenergic responsiveness in aortic-banded mini-swine. J Appl Physiol (1985). 2018 Apr 1;124(4):1034-1044.
  • Peana D, Domeier TL. Cardiomyocyte Ca2+ homeostasis as a therapeutic target in heart failure with reduced and preserved ejection fraction. Curr Opin Pharmacol. 2017 Apr;33:17-26.
  • Genovese NJ, Domeier TL, Telugu BP, Roberts RM. Enhanced Development of Skeletal Myotubes from Porcine Induced Pluripotent Stem Cells. Sci Rep. 2017 Feb 6;7:41833.
  • Wang X, Nichols L, Grunz-Borgmann EA, Sun Z, Meininger GA, Domeier TL, Baines CP, Parrish AR. Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells. Toxicol Lett. 2017 Jan 15;266:56-64.
  • Yue, Y., Binalsheikh, I.M., Leach, S.B., Domeier, T.L., and Duan, D. Prospect of gene therapy for cardiomyopathy in hereditary muscular dystrophy. Expert Opinion on Orphan Drugs. 2016; 4(2):169-183
  • Hiemstra, J.A., Lee, D.I., Chakir, K., Gutiérrez-Aguilar, M., Marshall, K.D., Zgoda, P.J., Cruz-Rivera, N., Dozier, D.G., Ferguson, B.S., Heublein, D.M., Burnett, J.C., Scherf, C., Ivey, J.R., Minervini, G., McDonald, K.S., Baines, C.P., Krenz, M, Domeier, T.L., and Emter, C.A. Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic-Banded Mini-Swine. J Am Heart Assoc. 2016 Apr 20;5(4)
  • Jia, G., Habibi, J., DeMarco, V.G., Martinez-Lemus, L.A., Ma, L., Whaley-Connell, A.T., Aroor, A.R., Domeier, T.L., Zhu, Y., Meininger, G.A., Barrett Mueller, K., Jaffe, I.Z., and Sowers, J.R. Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females. Hypertension. 2015 Dec;66(6):1159-67
  • Nance, M.E., Whitfield, J.T., Zhu, Y., Gibson, A.K., Hanft, L.M., Campbell, K.S., Meininger, G.A., McDonald, K.S., Segal, S.S., and Domeier, T.L. Attenuated sarcomere lengthening of the aged murine left ventricle observed using two-photon fluorescence microscopy. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H918-25
  • Bostick, B., Habibi, J., DeMarco, V.G., Jia, G., Domeier, T.L., Lambert, M.D., Aroor, A.R., Nistala, R., Bender, S.B., Garro, M., Hayden, M.R., Ma, L., Manrique Acevedo, C., and Sowers, J.R. Mineralocorticoid Receptor Blockade Prevents Western Diet-induced Diastolic Dysfunction in Female Mice. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1126-35
  • Clay, S.A.*, Domeier, T.L.*, Hanft, L.M., McDonald, K.S., Krenz, M. Elevated calcium transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan Syndrome with Multiple Lentigines. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1086-95
  • Socha, M.J., Boerman, E.M., Behringer, E.J., Shaw, R.L., Domeier, T.L., Segal, S.S. Advanced age protects microvascular endothelium from aberrant Ca2+ influx and cell death induced by hydrogen peroxide. J Physiol. 2015 May 1;593(9):2155-69
  • Domeier, T.L., Roberts, C.J., Gibson, A.K., Hanft, L.M., McDonald, K.S., Segal, S.S. Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice. Am J Physiol Heart Circ Physiol. 2014 Sep 15;307(6):H818-29
  • Hiemstra, J.A., Gutiérrez-Aguilar, M., Marshall, K.D., McCommis, K.S., Zgoda, P.J., Cruz-Rivera, N., Jenkins, N.T., Krenz, M. *Domeier, T.L. *, Baines, C.P. * , Emter, C.A. * A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini-swine with compensated heart failure. Physiol Rep. 2014 Jun 24;2(6)
  • Gutiérrez-Aguilar, M., Douglas, D.L., Gibson, A.K., Domeier, T.L., Molkentin, J.D., Baines, C.P. Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition. J Mol Cell Cardiol. 2014 Jul;72:316-25