134 Research Park Dr.
Columbia, MO 65212
- Cystic fibrosis
- Ion channel physiology
Areas of Expertise
- Ion channel biophysics
- Cystic Fibrosis
- ABC transporters
- Epithelial physiology
Education & Training
1990, PhD, Johns Hopkins University
- Xiaolong Gao., Yonghong Bai, and Tzyh-Chang Hwang. (2013). Cysteine scanning of CFTR’s first transmembrane segment reveals its plausible roles in gating and permeation. Biophys. J. 104:786-797.
- Kang-Yang Jih, and Tzyh-Chang Hwang. (2013). Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. Proc. Natl. Acad. Sci. USA. 110:4404-4409.
- Wen-Ying Lin, Kang-Yang Jih, and Tzyh-Chang Hwang. (2014). A single amino acid substitution converts ATP into an inhibitory ligand. J. Gen. Physiol.144:311-320.
- Han-I Jeh, Juinn-Tyng Yeh, and Tzyh-Chang Hwang. (2015). Modulation of CFTR gating by permeant ions. J. Gen. Physiol. 145:47-60.
- Xiaolong Gao, and Tzyh-Chang Hwang. (2015). Localizing a gate in CFTR. Proc. Natl. Acad. Sci. USA. 112:2461-2466.
- Jingyao Zhang, and Tzyh-Chang Hwang. (2015). The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane conductance Regulator Contributes to its Anion Permeation Pathway. Biochemistry 54:3839-50.
- Ying-Chun Yu, Yoshiro Sohma, and Tzyh-Chang Hwang. (2016). On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator. J. Physiol. 594:3227-3244.
- Xiaolong Gao, and Tzyh-Chang Hwang. (2016). Spatial positioning of pore-lining residues affirms an asymmetrical contribution of CFTR’s transmembrane segments to its anion permeation pathway. J. Gen. Physiol. 147:407-422.
- Wen-Ying Lin, Yoshiro Sohma, and Tzyh-Chang Hwang. (2016). Synergistic potentiation of CFTR gating by two chemically distinct potentiators ivacaftor (VX-770) and NPPB. Mole. Pharm. 90:275-285.