Tzyh-Chang Hwang, MD, PhD

Academic Information



134 Research Park Dr.
Columbia, MO 65212
United States

P. 573-882-2181

Research Interests

  • Cystic fibrosis
  • Ion channel physiology

Areas of Expertise

  • Ion channel biophysics
  • Cystic Fibrosis
  • ABC transporters
  • Epithelial physiology

Education & Training

Post-Graduate School

1990, PhD, Johns Hopkins University


  • Xiaolong Gao., Yonghong Bai, and Tzyh-Chang Hwang. (2013). Cysteine scanning of CFTR’s first transmembrane segment reveals its plausible roles in gating and permeation. Biophys. J. 104:786-797.
  • Kang-Yang Jih, and Tzyh-Chang Hwang. (2013). Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. Proc. Natl. Acad. Sci. USA. 110:4404-4409.
  • Wen-Ying Lin, Kang-Yang Jih, and Tzyh-Chang Hwang. (2014). A single amino acid substitution converts ATP into an inhibitory ligand. J. Gen. Physiol.144:311-320.
  • Han-I Jeh, Juinn-Tyng Yeh, and Tzyh-Chang Hwang. (2015). Modulation of CFTR gating by permeant ions. J. Gen. Physiol. 145:47-60.
  • Xiaolong Gao, and Tzyh-Chang Hwang. (2015). Localizing a gate in CFTR. Proc. Natl. Acad. Sci. USA. 112:2461-2466.
  • Jingyao Zhang, and Tzyh-Chang Hwang. (2015). The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane conductance Regulator Contributes to its Anion Permeation Pathway. Biochemistry 54:3839-50.
  • Ying-Chun Yu, Yoshiro Sohma, and Tzyh-Chang Hwang. (2016). On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator. J. Physiol. 594:3227-3244.
  • Xiaolong Gao, and Tzyh-Chang Hwang. (2016). Spatial positioning of pore-lining residues affirms an asymmetrical contribution of CFTR’s transmembrane segments to its anion permeation pathway. J. Gen. Physiol. 147:407-422.
  • Wen-Ying Lin, Yoshiro Sohma, and Tzyh-Chang Hwang. (2016). Synergistic potentiation of CFTR gating by two chemically distinct potentiators ivacaftor (VX-770) and NPPB. Mole. Pharm. 90:275-285.