William Durante, PhD

Profile

My laboratory has a long standing interest in studying the synthesis and function of endogenously derived signaling gases such as nitric oxide, carbon monoxide, hydrogen sulfide, and ammonia. I'm especially interested in understanding how abnormalities in the production of these gases in the circulation leads to vascular dysfunction and hypertension in metabolic disorders, including obesity and diabetes. Given that these signaling gases are largely derived from amino acids, I am also investigating the transport and metabolism of amino acids by vascular cells, and determining whether disturbances in the uptake of amino acids contributes to the development of vascular disease.

Academic Information

Professor

Office

One Hospital Drive
Columbia, MO 65212
United States

P. 573-882-3886

Research Interests

  • Synthesis and function of endogenously derived signaling gases
  • Vascular dysfunction and hypertension in metabolic disorders, including obesity and diabetes

Areas of Expertise

  • Signaling gases in vascular injury and disease
  • Regulation of amino acid transport and metabolism by vascular cells
  • Hemodynamic forces and vascular cell function
  • Vascular dysfunction in metabolic disease

Education & Training

Post-Graduate School

1989, PhD, University of Toronto; 1985, MS, University of Toronto

Awards & Honors

  • Ontario Graduate Scholarship
  • University of Toronto Open Fellowship
  • Proctor and Gamble Professional Opportunity Award
  • American Heart Association Travel Award Established Investigator Award from the American Heart Association
  • Order of Socrates for Excellence in Teaching from the University of Missouri School of Medicine
  • Fellow of the American Heart Association
  • Fellow of the American Physiological Association

Publications

  • Chang C-F, Liu XM, Peyton KJ, Durante W. Heme oxygenase-1 counteracts contrast media-induced endothelial cell dysfunction. Biochem. Pharmacol.87:303-311, 2014.
  • Johnson FK, Peyton KJ, Liu XM, Shebib, AR, Johnson RA, Durante W. Arginase promotes endothelial dysfunction and hypertension in obese rats. Obesity23:383-390, 2015.
  • Durante W. Bilirubin: striking gold in diabetic vasculopathy? Diabetes 64:1506-1508, 2015.
  • Peyton KJ, Liu XM, Durante W. Prolonged cyclic strain inhibits human endothelial cell proliferation. Front. Biosci. 8:205-212, 2016.
  • Liu XM, Durante ZE, Peyton KJ, Durante W. Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial dysfunction. Free Radic. Biol. Med. 94:218-229, 2016.
  • Jia G, Durante W, Sowers JR. Endothelium-derived hyperpolarizing factors: a potential therapeutic target of vascular dysfunction in obesity and insulin resistance. Diabetes 65:2118-2120, 2016.
  • Durante W. Targeting endoplasmic reticulum stress in hypoxia-induced cardiac injury. Vascul. Pharmacol. 83:1-3, 2016.
  • Durante W. Hydrogen sulfide therapy in diabetes-accelerated atherosclerosis: a whiff of success. Diabetes 65:2832-2834, 2016.
  • Bostick B, Aroor AR, Habibi J, Durante W, Ma L, Demarco VG, Garro M, Hayden MR, Booth FW, Sowers JR. Daily exercise prevents diastolic dysfunction in a female model of western diet induced obesity with amelioration of myocardial oxidative stress and fibrosis with maintenance of myocardial heme oxygenase-1 levels. Metabolism 66:14-22, 2017.
  • Liu XM, Peyton KJ, Durante W. Ammonia promotes endothelial cell survival via the heme oxygenase-1-mediated release of carbon monoxide. Free Radic. Biol. Med. 102:37-46, 2017.