William Durante, PhD


My laboratory has a long standing interest in studying the synthesis and function of endogenously derived signaling gases such as nitric oxide, carbon monoxide, hydrogen sulfide, and ammonia. I'm especially interested in understanding how abnormalities in the production of these gases in the circulation leads to vascular dysfunction and hypertension in metabolic disorders, including obesity and diabetes. Given that these signaling gases are largely derived from amino acids, I am also investigating the transport and metabolism of amino acids by vascular cells, and determining whether disturbances in the uptake of amino acids contributes to the development of vascular disease.

Academic Information



One Hospital Drive
M409 Medical School Building
Columbia, MO 65212
United States

P. 573-882-3886

Research Interests

  • Vascular Biology

Areas of Expertise

  • Signaling gases in vascular injury and disease
  • Regulation of amino acid transport and metabolism by vascular cells
  • Hemodynamic forces and vascular cell function
  • Vascular dysfunction in metabolic disease

Education & Training

Post-Graduate School

1989, PhD, University of Toronto; 1985, MS, University of Toronto

Awards & Honors

  • Ontario Graduate Scholarship
  • University of Toronto Open Fellowship
  • Proctor and Gamble Professional Opportunity Award
  • American Heart Association Travel Award
  • Established Investigator Award from the American Heart Association
  • Order of Socrates for Excellence in Teaching from the University of Missouri School of Medicine
  • Fellow of the American Heart Association
  • Fellow of the American Physiological Association


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