Profile
Dr. Wan’s long-term career goals are to understand how zoonotic pathogens (especially influenza A viruses) emerge and re-emerge at the animal-human interface and to improve the effectiveness of the influenza vaccines in disease prevention and control by developing and applying systems biology based translational approaches. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application.
Academic Information
Professor
Curators’ Distinguished Professor
Office
471D Bond Life Sciences Center
Columbia, MO 65211
United States
P. 573-882-8943
Research Interests
- Influenza
- Systems Biology
- Computational Biology
- Virology
- Immune Response to Pathogens
- Molecular Evolution
- Vaccine
- Animal model
- Genomics, Proteomics, and Glycomics
Areas of Expertise
- Influenza
- Virology
- Microbiology
- Vaccine
- Evolutionary Biology
- Systems Biology
- Computational Biology and Machine Learning
Education & Training
2005 Postdoctoral Fellow
University of Missouri, Columbia, MO
2003 Postdoctoral Fellow
Oak Ridge National University, Oak Ridge, TN
2002 MS
Mississippi State University, Mississippi State, MS
2002 PhD
Mississippi State University, Mississippi State, MS
1998 MS
South China Agricultural University, Guangzhou, Guangdong
1995 BS
Jiangxi Agricultural University, Nanchang, Jiangxi
Awards & Honors
- 2017 Ralph E. Powe Research Excellence Award, Mississippi State University
- 2016 Distinguished Seminar Speaker, Walter Reed Army Institute of Research
- 2014 Pegasus Faculty Research Awards, College of Vet Med, Mississippi State University
- 2013 Superior Faculty Award, Mississippi State University
- 2013 Faculty Leadership Award, Mississippi State University
- 2012 Pfizer Award for Veterinary Research Excellence, Mississippi State University
In the News
Publications
A full list of publications can be found on PubMed.
- Guan, M., J. S. Hall, X. Zhang, R. J. Dusek, A. K. Olivier, L. Liu, L. Li, S. t Krauss, A. Danner, T. Li, W. Rutvisuttinunt, X. Lin, G. T. Hallgrimsson, S. B. Ragnarsdottir, S. R. Vignisson, J. TeSlaa, S. W. Nashold, R. Jarman, and X.-F. Wan. Aerosol transmission of gull-origin Iceland subtype H10N7 influenza A virus in ferrets. J Virol. 2019 Apr 17. pii: JVI.00282-19. [Epub ahead of print]
- Zhang, X., C. Outlaw, A. K. Olivier, A. Woolums, W. Epperson, and X.-F. Wan. 2019. Pathogenesis of co-infections of influenza D virus and Mannheimia haemolytica in cattle. Veterinary Microbiology, Vet Microbiol. 2019 Apr;231:246-253.
- Wen, F, and X.-F. Wan. Influenza Neuraminidase: Underrated Role in Receptor Binding. 2019. Trends in Microbiology, 2019 Mar 28. pii: S0966-842X(19)30065-4. doi: 10.1016/j.tim.2019.03.001.
- Han, L., L. Li, F. Wen, L. Zhong, T. Zhang, and X.-F. Wan. 2019. Graph-Guided multi-task sparse
learning model: a method for identifying antigenic variants of influenza A(H3N2) virus. Bioinformatics, 2019 Jan 1; 35(1):77-87 doi: 10.1093/bioinformatics/bty457. - Zhang, X., H. Sun, F. L. Cunningham, L. Li, K. Hanson-Dorr, M. W. Hopken, J. Cooley, L.-P. Long, J. A. Baroch, T. Li, B. S. Schmit, X. Lin, A. K. Olivier, R. G. Jarman, T. J. DeLiberto, and X.-F. Wan. 2018. Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine. PLoS Pathogens, 14(12):e1007417.
- Wen, F., S. Blackmon, A. K. Olivier, L. Li, G. Guan, H. Sun, and P. Wang, and X.-F. Wan. 2018. Mutation W222L at the receptor binding site of hemagglutinin could facilitate viral adaption from equine influenza A(H3N8) virus to dogs. Journal of Virology, 92(18). pii: e01115-18.
- Li, L., A. S. Bowman, T. J. DeLiberto, M. L. Killian, S. Krauss, J. M. Nolting, M. K. Torchetti, A. M. Ramey, A. B. Reeves, D. E. Stallknecht, R. J. Webby, X.-F. Wan. 2018. Genetic evidence supports sporadic and independent introductions of low pathogenic H5 avian influenza A viruses from wild birds to domestic poultry in North America. Journal of Virology, 92(19). pii: e00913-18.
- Ferguson, L, K. Luo, A. K. Olivier, F. L. Cunningham, S. Blackmon, K. Hanson-Dorr, H. Sun, J. Baroch, M. W. Lutman, B. Quade, W. Epperson, and R. Webby, T. J. DeLiberto, and X.-F. Wan. 2018. Influenza D Virus Infection in Feral Swine Populations in the United States. Emerging Infectious Diseases, 24(6): 1019-1027.
- Kosikova, M., L. Li, P. Radvak, Z. Ye, X.-F. Wan, and H. Xie. 2018. Imprinting of repeated influenza A/H3 exposures on antibody quantity and quality: implications on seasonal vaccine strain selection and vaccine performance. Clinical Infectious Diseases, Apr 17. doi: 10.1093/cid/ciy327.
- Wen, F., L. Li, N. Zhao, M.-J. Chiang, H. Xie, J. Cooley, R. Webby, P. G. Wang, and X.-F. Wan. 2018. A Y161F hemagglutinin substitution increases thermostability and improves yields of 2009 H1N1 influenza A Virus in cells. Journal of Virology, 92(2). pii: e01621-17.
- Sun, H, S. Blackmon, G. Yang, K. Waters, T. Li, R. Tangwangvivat, Y. Xu, D. Shyu, F. Wen, J. Cooley, L. Senter, X. Lin, R. Jarman, L. Hanson, R. Webby, and X.-F. Wan. 2017. Zoonotic Risk, Pathogenesis, and Transmission of Avian-Origin H3N2 Canine Influenza Virus. Journal of Virology, 91(21). pii: e00637-17.
- Martin, B. E., H. Sun, M. Carrel, F. L. Cunningham, J. A. Baroch, S. G. Young, B. Schmit, J. Nolting, K.-J. Yoon, M. W. Lutman, K. Pedersen, K. Lager, A. Bowman, R. Slemons, D. R. Smith, T. DeLiberto, and X.-F. Wan. 2017. US Feral Swine were exposed to both avian and swine influenza A viruses. Applied and Environmental Microbiology, 83(19). pii: e01346-17.
- Xie, H., L. Li, Z. Ye, X. Li, E. P. Plant, O. Zoueva, Y. Zhao, X. Jing, Z. Lin, T. Kawano, M.-J. Chiang, C. Finch, M. Kosikova, A. Zhang, Y. Zhu, and X.-F. Wan. 2017. Differential Effects of Prior Influenza Exposures on H3N2 Cross-reactivity of Human Post-vaccination Sera. Clinical Infectious Diseases, 65(2):259-267.
- Xu, Y., A. M. Ramey, A. S. Bowman, T. J. DeLiberto, M. L. Killian, S. Krauss, J. M. Nolting, M. K. Torchetti, A. B. Reeves, R. J. Webby, D. E. Stallknecht, X.-F. Wan. Low Pathogenic Influenza A Viruses in North American Diving Ducks Contribute to the Emergence of a Novel Highly Pathogenic Influenza A(H7N8) Virus. Journal of Virology, 91(9). pii: e02208-16.
- Martin, B., A. S. Bowman, L. Li, J. Nolting, D. R. Smith, L. Hanson, and X.-F. Wan. Detection of Antigenic Variants of Swine Subtype H3 Influenza A Viruses from Clinical Samples. 2017. Journal of Clinical Microbiology, 55(4):1037-1045.