Academic Information
Assistant Professor of Ophthalmology
Office
1 Hospital Dr
University Hospital, RM 659
Columbia, MO 65212
United States
P. 573-882-8422
Research Interests
- Glaucoma
- Neurodegeneration
- Neuroinflammation
- Autophagy/Mitophagy
- Visual centers of the Brain and Synaptic dysfunction
- Trabecular meshwork Dysfunction
- Gene Therapy
Areas of Expertise
- Glaucomatous neurodegeneration
- Mitochondrial dysfunction and mitophagy/autophagy
- Chronic endoplasmic reticulum stress
- Neuroinflammation
- Synaptic dysfunction
- Gene therapy
- Mouse models of Glaucoma
- Ocular injections
Education & Training
Fellowship
2017-2023 Postdoctoral Fellowship, University of North Texas Health Science Center, Fort Worth, TX, USA
Degrees
2017 PhD, University of Madras, Chennai, India
2009 MSc, Sri Venkateswara University, Tirupati, India
Awards & Honors
- 2022: BrightFocus Foundation National Glaucoma Research Award
- 2021: NEI/NIH Pathway to Independence Awards (K99/R00)
- 2021: Recipient of Qais Farjo, MD Memorial Travel Grant, ARVO
- 2021: Recipient of BrightFocus foundation Honorable Mention Paper Award, AOPT
- 2019: Recipient of Postdoctoral AOPT NIH Travel Award
- 2018: Recipient of Graduate School of Biomedical Sciences Postdoctoral travel award by UNTHSC
- 2018: Recipient of Dr. Thomas Yorio travel award, UNTHSC
- 2018: The best poster presentation at Research Appreciation Day, UNTHSC
- 2013-2015: Awarded Senior Research Fellowship from CSIR- India
- 2010-2012: Awarded Junior Research Fellowship from CSIR- India
- 2009: Qualified Joint CSIR-UGC National eligibility test for Lectureship (NET)
Professional Memberships
- 2019- Present - Member, Association for Ocular Pharmacology and Therapeutics (AOPT)
- 2017-Present -Member, Association for Research in Vision & Ophthalmology (ARVO)
- 2018-2019 -Member, American Association of the Advancement of Science (AAAS)
- 2012-2014 -Member, Indian Immunology Society
- 2007 -Member, Society of Biochemical Chemists of India
Publications
- Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma.
Patel PD, Chen YL, Kasetti RB, Maddineni P, Mayhew W, Millar JC, Ellis DZ, Sonkusare SK, Zode GS.
Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2022461118. doi: 10.1073/pnas.2022461118. - Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin.
Kasetti RB, Maddineni P, Kiehlbauch C, Patil S, Searby CC, Levine B, Sheffield VC, Zode GS.
JCI Insight. 2021 Mar 8;6(5):e143359. doi: 10.1172/jci.insight.143359. - ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load.
Kasetti RB, Patel PD, Maddineni P, Patil S, Kiehlbauch C, Millar JC, Searby CC, Raghunathan V, Sheffield VC, Zode GS.
Nat Commun. 2020 Nov 5;11(1):5594. doi: 10.1038/s41467-020-19352-1. - Fibulin-3 knockout mice demonstrate corneal dysfunction but maintain normal retinal integrity.
Daniel S, Renwick M, Chau VQ, Datta S, Maddineni P, Zode G, Wade EM, Robertson SP, Petroll WM, Hulleman JD.
J Mol Med (Berl). 2020 Nov;98(11):1639-1656. doi: 10.1007/s00109-020-01974-z. Epub 2020 Sep 22. - Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9.
Maddineni P, Kasetti RB, Kodati B, Yacoub S, Zode GS.
Int J Mol Sci. 2021 Sep 18;22(18):10095. doi: 10.3390/ijms221810095. - Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma.
Kasetti RB, Maddineni P, Kodati B, Nagarajan B, Yacoub S.
Int J Mol Sci. 2021 Nov 19;22(22):12508. doi: 10.3390/ijms222212508. - Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork.
Kasetti RB, Patel PD, Maddineni P, Zode GS. PLoS One.
2020 Jun 24;15(6):e0232111. doi: 10.1371/journal.pone.0232111. eCollection 2020. - CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma.
Maddineni P, Kasetti RB, Patel PD, Millar JC, Kiehlbauch C, Clark AF, Zode GS.
Mol Neurodegener. 2020 Aug 27;15(1):48. doi: 10.1186/s13024-020-00400-9.
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