Shankar Iyer, PhD

Shankar Iyer, PhD

Neurology

Assistant Research Professor

573-882-6573

Academic Information

Assistant Research Professor
P. 573-882-6573

Research Interests

  • Inflammation
  • Innate immunity
  • Inflammasomes
  • Neuro-inflammation
  • Host pathogen interactions
  • Signal transduction

Areas of Expertise

  • Inflammation
  • Innate immunity
  • Inflammasomes
  • Neuro-inflammation
  • Host pathogen interactions
  • Signal transduction

Education & Training

Medical School

Bombay University, Bombay India

Awards & Honors

  • Invited Reviewer: Biochimica Biophysica Acta ( BBA- General Subjects, Elseiver)
  • Ad- Hoc Reviewer: Journal of Biological Chemistry
  • Invited Reviewer : Neurochemical Research

Publications

  • Shankar S. Iyer, Qiong He, John R. Janczy, Eric I. Elliot, Zhenyu Zhong, Alicia K. Olivier, Jeffrey J. Sadler, Vickie Knepper-Adrian, Renzhi han, Liang Qiao, Stephanie C. Eisenbarth, William M. Nauseef, Suzanne L. Cassel, and Fayyaz S. Sutterwala. 2013. Mitochondrial cardiolipin is required for Nlrp3 Inflammasome activation. Immunity 39: 311-323. [Paper chosen as cover article for the August 22, 2013 issue of Immunity by Cell Press and Previewed by Luke A. O’Neill in Cell Metabolism 18: 610-612, 2013].
    S.S. Iyer, W.P. Pulskens, J.J. Sadler, L.M. Butter, G.J. Teske, T. Ulland, S.C. Eisenbarth, S. Florquin, R.A. Flavell, J.C. Leemans, and F.S. Sutterwala. 2009. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc. Natl. Acad. Sci. U S A. 106:20388-93. [Paper chosen as Editor’s Choice on Inflammation –Nancy R. Gough 2009. Those Irritating Acellular Mitochondria. Science Signaling 2: ec388. [ Paper cited in Clinical Implications of Basic Research – The Mitochondrion--- A Trojan Horse that kicks off inflammation? Angelo A. Manfredi and Patrizia Rovere-Querini 2010. N. Engl. J. Med. :362 (22), 2132-2134.
  • Cassel, S.L., S.C. Eisenbarth, S.S. Iyer, J.J. Sadler, O.R. Colegio, L.A. Tephly, A.B. Carter, P.B. Rothman, R.A. Flavell, and F.S. Sutterwala. 2008. The Nalp3 inflammasome is essential for the development of silicosis. Proc. Natl. Acad. Sci. U.S.A. 105:9035-9040
  • Kusner, D.J., Thompson, C.R., Melrose, N.A., Pitson, S.M., Obeid, L.M. and Iyer, S. S. The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. J. Biol. Chem 2007, 282: 23147-23162.
  •  
  • Book Chapter:
  • Iyer S.S. and Kusner D.J. Coordinate regulation of sphingosine kinase and actin dynamics. In: Neil Reiner (Ed) Macrophages and Dendritic cells. Methods in Molecular Biology Series vol.531, Humana Press Inc. Totowa, NJ. 2009.
    Iyer S.S. and Kusner D.J. Assay of Phospholpase D activity in cell- free systems. In: Ali, H. and Haribabu, B.(Eds) Transmembrane Signaling Protocols, 2nd Edition. Methods in Molecular Biology, vol 332. Humana Press Inc. Totowa, NJ. 2006.
    Mehta N.G., Kalraiya R.D. Iyer S.S. In: Kidwai A.M., Upreti R.K. and Ray P.K. (Eds). Biomembranes in Health and Disease. Today and Tomorrow’s Printers. New Delhi. 1991.