The Department of Orthopaedic Surgery has dedicated significant resources to the pursuit of clinical, translational, and basic science research.
Our state-of-the-art Thompson Lab, housed on the fourth floor of Missouri Orthopaedic Institute (MOI), includes ~12,000 square feet solely dedicated to research for a team of more than 50 researchers representing 13 different specialties.
The lab houses Basic Science and Translational Research, Skeletal Morphology Research, Bioengineering Research, and Clinical Research teams and facilities. MOI houses over 40 clinical faculty specializing in sports medicine (primary care and surgical), joint replacement, pediatrics, hip and knee, foot and ankle, shoulder, hand, spine, trauma, limb preservation, regenerative medicine (Mizzou BioJoint® Center), physical medicine and rehabilitation, and diagnostic imaging.
More than 200 other health care professionals and staff provide care and services including nursing, imaging, prosthetics, pharmacy, physical therapy, occupational therapy, nutrition, and mental health. Our internationally recognized faculty and staff — combined with our state-of-the-art Thompson Lab and variety and volume of patients — create an optimal environment for bedside-to-bench-to-bedside research. See below for a full list of active projects.
Featured Clinical Researcher of the Quarter: Dr. Shen-Ying (Richard) Ma
Dr. Ma is a true clinician-scientist. His career is driven by his exploration of scientific questions, aiming at improving the lives of our patients. Dr. Ma’s research focus is primarily in sports medicine, including anterior cruciate ligament (ACL) reconstruction, elbow and shoulder surgeries, and arthroscopic surgery.
He leads efforts to develop a rodent model to understand how the external mechanical environment and stimulus affects healing of the ACL graft. He directs an ACL research program within the Thompson Lab that includes work on understanding the variable biological responses of intraarticular tissues relevant in ACL injured knees and human studies evaluating biological differences of ACL autograft tissues. He also works with canine models to understand how ACL injury may result in loss of a native neuromuscular reflex, which may explain the high clinical incidence of post-traumatic osteoarthritis with ACL injuries.
Dr. Ma is the 2018 recipient of MU School of Medicine's Dorsett L. Spurgeon, MD, Distinguished Medical Research Award. He will present his work and be recognized at the 2018 Health Sciences Research Day.
Currently, Dr. Ma is leading the following research studies:
- Determining sex-related differences in ACL healing after BTB reconstruction
- Biomarkers of ACL healing in response to mechanical strain
- Responses of common ACL allografts to mechanical strain
- Early cellular responses to mechanical strain by tissues involved in ACL repair
- Biomarkers for ACL rupture
- Metabolic characterization of common autografts used for ACL reconstruction
- Comparison of metabolism of ACL remnant, synovium, and common autografts