Psychiatry Research

Learn more about the Department of Psychiatry's research programs.

The Center for Child Well-being

Laine Young-Walker, MD, Chair of Department of Psychiatry

Kelli Buchanan, Center Director

Overview

The Center for Child Well-Being is dedicated to supporting parents, professionals, and community organizations in fostering the mental health and well-being of children. Whether you're a caregiver, educator, provider, or community leader, we partner with you to create a healthier, more supportive environment for children to thrive.

In the first nine months of FY26, we served over 8000 Missourians in 113 out of 114 counties, and St. Louis City.

Our vision is a future in which every child in Missouri has a strong foundation for lifelong health.

Clinical and Translational Science Unit (CTSU)

Muaid Ithman, MD, Researcher

Overview

Dr. Ithman’s program of research is focused on advancing mental health care through rigorous clinical trials organized around testing the safety and efficacy of innovative treatments for mood disorders, including depression and anxiety.

Current trials explore a wide range of treatment modalities, including pharmacological interventions that investigate novel medications to help improve symptoms associated with mood disorders, as well as psychotherapy-based treatments that explore new therapeutic approaches. Current trials include the investigation of psychedelic-assisted therapy.

Our team of expert clinicians and researchers work closely with participants to ensure the highest standards of care and ethical conduct throughout each trial. If you are interested in learning more or participating in one of our clinical trials, please contact the Clinical and Translational Science Unit (CTSU)

Substance Use in Daily Life Lab

Andrea Wycoff, PhD, Director

Overview

The Substance Use in Daily Life (SUDL) Lab is led by Andrea Wycoff, PhD. The SUDL Lab uses daily-life assessment methods to understand how substance use relates to emotions, cognitions, and other experiences in individuals’ natural environments. Recent and ongoing research studies focus on how alcohol and cannabis use impact each other, and how use of one substance might influence recovery efforts for another substance. Overarching goals for this program of research are to better understand how people make decisions about substance use and identify productive treatment targets for individuals who are hoping to cut back.

Health Innovation and Treatment Research Lab

Mary Beth Miller, PhD, Director

Overview

The Health Intervention and Treatment Research Lab (HIT Lab) is led by Mary Beth Miller, PhD. Research efforts are focused on how and why people change their health habits, including the study of drug and alcohol addiction, nutrition and sleep.

Recent studies have explored ways to improve the efficacy of addiction prevention and treatment in young people and in veterans.

Health Neuroscience Center (NHC)

Brett Froeliger, PhD, Director

Overview

The Health Neuroscience Center (HNC) is focused on integrating cognitive neuroscience, genetics, AI and clinical research to accelerate the discovery of new treatments for drug addiction in order to improve mental health and well-being. In order to learn more about the work being conducted in the HNC, or consider participating in one of our paid research studies, please visit the Health Neuroscience Center web site.

Predicting and controlling aggression on the part of psychiatric inpatients

Niels Beck, PhD, Program Coordinator

Overview

This research program is currently underway at the State Hospital at Fulton, where the department operates a forensic fellowship program. The Fulton campus includes a 200-bed, maximum-security forensic hospital, the only one of its kind in Missouri.

Niels Beck, PhD, coordinates this effort and studies are being conducted that involve abstracting data from hospital records of highly assaultive patients, including seclusion/restraint records, and tracking the types of medications used to control these behaviors. The goal is to develop medication algorithms for the management of aggressive behavior.

Additional investigations are underway that examine differences in staff/patient interactional patterns in highly assaultive vs. non-assaultive patient samples, the frequency of abuse and neglect in the family histories of these patient groups and a genetic study that targets several polymorphisms of genes thought to play a role in the development of hyper-emotionality and aggressive behavior. 

Most recently, Dr. Beck has begun replicating and extending the results of his work at the State Hospital in Fulton to a variety of University Hospital Settings, including the ED, and the inpatient child/adolescent and adult psychiatric wards.

Residents in the second and fourth years, as well as forensic fellows, have an opportunity to work with Beck on these projects.