Clinical and translational science is the field of research focused on the process of using findings from the laboratory or clinic to create interventions to improve human health.
iCATS facilitates a highly productive and collaborative environment to nurture clinical and translational science at the University of Missouri. iCATS has specific areas of strength through which it helps researchers develop solutions for challenging health issues.
iCATS connects researchers to state-of-the-art software and hardware, as well as improved access to data. iCATS also provides user-friendly informatics support to researchers and assists in the development and deployment of new informatics tools.
MU Informatics Institute (MUII) is the hub for University of Missouri System informatics activities. The MUII offers informatics doctoral degrees in two emphasis areas, bioinformatics and health informatics. The MUII also hosts pre-doctoral fellows in the National Library of Medicine Biomedical and Health Informatics Research Training Program at MU.
Tiger Institute for Health Innovation was formed by Cerner Corporation, the world’s largest supplier of health information technology, and the University of Missouri. The Institute supports MU and Cerner in jointly developing and studying innovative medical informatics solutions that can facilitate storage and retrieval of patient-centered health care information.
The Department of IT Research Support Computing Group, in conjunction with the University of Missouri Bioinformatics Consortium (UMBC), operates high-performance computing systems to support research on MU’s campus. Established in 2001, the UMBC provides centralized, high-capacity data storage and analytical tools that can be used over high-speed Internet2 connections in support of research. The current system (Lewis) is a 1300 core HPC InfiniBand cluster with more than a Petabyte of high-speed storage. The cluster also supports a number of high-memory “fat” nodes and GPU compute nodes for scientific software. Individual, one-on-one consulting is available to provide support for all phases of problem evolution from inception to final results. This can include software recommendations, formulation of the problem or optimization of a single processor performance as well as communications support.
Biostatistics and Research Design
iCATS connects investigators with resources that help equip them to design perform high-quality research. The Biostatistics and Research Design Unit at MU’s School of Medicine offers support with grant proposal development, experimental design, sample size determination, data management, statistical analyses of all types, development and application of new statistical methodologies, and education in experimental design and statistics.
Clinical research resources at the University of Missouri continue to grow due to expansion, reorganization, and integration efforts led by iCATS. The institute has reengineered support programs and is continuously making new resources available to both scientists and patients participating in clinical research.
The University of Missouri has approximately 235 clinical trials in progress with approximately 4,500 human volunteers. MU’s Clinical Research Center supports the scientists and patients involved in these studies with its staff of experienced clinical trials experts, trial registration support and other resources.
Regulatory Knowledge and Support
iCATS helps investigators navigate the complex and ever-changing environment of clinical and translational research regulations so investigators can maintain MU’s record of high-quality research that is responsible, safe and compliant with all applicable federal, state and university rules and regulations.
The Data and Safety Monitoring Committee (DSMC) operates in accordance with NIH, NCI, and FDA guidelines. It supports clinical investigators and the IRB in protecting human research participants and ensuring the integrity and scientific validity of research data. The committee serves as a resource for scientists who do not have access to other data and safety monitoring boards, especially for investigator-initiated trials. The committee also serves as a resource for the IRB in situations where monitoring is needed.
For information related to research compliance, please refer to https://research.missouri.edu/compliance
For information related to healthcare compliance, please refer to https://www.muhealth.org/about-us/corporate-compliance
Life Sciences Innovation
The University of Missouri Coulter Biomedical Accelerator Program (MU Coulter Accelerator Program) capitalizes on the best of academia and industry to accelerate the translation of biomedical innovations into products that improve patient care. The MU Coulter Program bridges the gap between academic research and industry by providing funding to engineer-clinician teams. These teams perform experiments to generate data that subsequently attract the professional funding needed to continue commercialization of the technology.
Mizzou OneHealth Biorepository
The Mizzou OneHealth Biorepository (OHB) provides centralized services for procuring, obtaining, processing, and storing human biospecimens for approved translational research projects. The OHB supports all members of the MU biomedical research community, serves as the tissue bank of the Ellis Fischel Cancer Center, and collaborates with the Siteman Cancer Center's Biorepository at Washington University in St. Louis. Learn more.