Research: Studies Helicobacter pylori and Francisella tularensis with a focus on pathogen manipulation of macrophage and neutrophil function and dysregulation of the inflammatory response. Our approach is multi-faceted and addresses fundamental questions in cellular microbiology which lie at the interface of bacterial pathogenesis, phagocyte cell biology and innate immunity.
Research: Investigate the pathogenesis of chronic intestinal mucosal inflammation and inflammation-associated cancer that occurs in some, but not all, strains of mice colonized by Helicobacter hepaticus, so that new therapeutic and preventative strategies can be developed for similar conditions in humans and domestic animals (e.g. inflammatory bowel diseases such as Crohn’s disease in people).
Research: Focuses on interactions of arboviruses (i.e. dengue virus, Sindbis virus, chikungunya virus) with the yellow fever mosquito, Aedes aegypti. One research effort focuses on the mosquito’s innate RNA interference (RNAi) pathway. We investigate how RNAi modulates arbovirus infections and how the RNAi pathway can be manipulated to block arbovirus replication in relevant mosquito tissues.
Research: Utilizes nucleic acid technologies, including aptamers and the CRISPR/Cas9 system, to explore virus and host biology, identify novel host targets, modulate innate immune and cell death signaling pathways, and the probe the host response to viral infection
Molecular Microbiology and Immunology, Department of Veterinary Pathobiology
Research: Dr. Ma's current research focuses on understanding mechanisms of pathogenesis and transmissibility, virus-host interaction and developing vaccines and antivirals for different zoonotic viral pathogens, such as Influenza virus, Rift Valley fever virus and other viral infections.
Molecular Microbiology and Immunology, Biochemistry
Research: Dr. Petris Investigates how minerals are accumulated within the body at the right locations and in the right concentrations. Certain conditions such as Alzheimer’s disease, cancer and microbial infection disrupt the cellular balance of minerals that may exacerbate the pathology or improve outcome.
Molecular Microbiology and Immunology, Surgery, Bioengineering
Focusing on physiologic signaling networks and how they function in molecular and cellular immunity. A main goal is to increase understanding of how T cells of the immune system decide whether to destroy or tolerate healthy, infected or cancerous tissue, with an eye toward applying lessons learned to design immunotherapies.
Research: Immunity of the zoonotic, intracellular, bacterial pathogens Brucella and Francisella. Current projects are the immunity and immunopathology of Brucellosis and the immunity and immunotherapy of Tularemia.
Research: Regulation of virulence gene expression; global regulation of enterotoxin gene expression in Staphylococcus aureus; expression of sporulation-specific proteins in Bacillus; characterization of the leukotoxin of Fusobacterium necrophorum.
Research: Biology of ixodid ticks and tick-borne pathogens. This program is centered on understanding the mechanisms responsible for transmission and pathogenesis of tick-borne members of the bacterial order Rickettsiales, especially the family Anaplasmataceae.
Molecular Microbiology & Immunology and Biochemistry
Research: Understanding how zoonotic pathogens (especially influenza A viruses) emerge and re-emerge at the animal-human interface and to improve the effectiveness of the influenza vaccines in disease prevention and control by developing and applying systems biology based translational approaches.
Molecular Microbiology and Immunology, Child Health
Research: Dr. Yolcu has significant interest in using hematopoietic stem cells as a powerful scheme for immunomodulation with main focus on the treatment of autoimmune diseases, such as type 1 diabetes, as well as bone marrow failure syndrome and hematological malignancies.